Full Press Release Details
IMMUNOPRECISE ANTIBODIES LTD.
MANAGEMENT DISCUSSION AND ANALYSIS
FOR THE NINE MONTHS ENDED JANUARY 31, 2022
The following Management's Discussion and Analysis ("MD&A") should be read in conjunction with the unaudited condensed interim consolidated financial statements of ImmunoPrecise Antibodies Ltd. ("the Company", "ImmunoPrecise" or "IPA") for the three and nine months ended January 31, 2022, together with the audited consolidated financial statements and accompanying MD&A of the Company for the year ended April 30, 2021. This MD&A is the responsibility of management and was reviewed and approved by the Board of Directors of IPA on March 16, 2022.
The referenced financial statements have been prepared in accordance with International Financial Reporting Standards ("IFRS"), as issued by the International Accounting Standards Board and as applicable to the preparation of interim financial statements, including IAS 34, Interim Financial Reporting. Except as otherwise noted, all dollar figures in this MD&A are stated in Canadian dollars, which is the Company's reporting currency.
FORWARD-LOOKING STATEMENTS
This MD&A contains certain statements that constitute "forward-looking statements" within the meaning of National Instrument 51-102, Continuous Disclosure Obligations of the Canadian Securities Administrators.
Forward-looking statements often, but not always, are identified by the use of words such as "seek", "anticipate", "believe", "plan", "estimate", "expect", "targeting" and "intend" and statements that an event or result "may", "will", "should", "could", or "might" occur or be achieved and other similar expressions.
In this MD&A, forward-looking statements include statements regarding: the Company's future plans and expenditures, the satisfaction of rights and performance of obligations under agreements to which the Company is a party; product development; future revenue growth; research and development initiatives; changes to office locations; general market trends and developments; the timing and results of patent and IND filings, including with respect to the PolyTope TATX-03 cocktail; and the Company's ability to sustain existing operations. The forward-looking statements that are contained in this MD&A involve a number of risks and uncertainties and are based on certain assumptions, including: the progress, timing and costs related to the execution of the Company's business plan and strategy; estimates and projections regarding the industry in which the Company operates; the future success of research and development activities; the absence of material changes in general business and economic conditions; estimates regarding the future financing and capital requirements; and the absence of adverse changes in relevant laws and regulations. As a consequence, actual results might differ materially from results forecast or suggested in these forward-looking statements. Some of these risks and uncertainties are identified under the heading "RISKS AND UNCERTAINTIES" in this MD&A.
Furthermore, forward-looking statements contained herein are made as of the date of this MD&A and the Company disclaims any obligation to update any forward-looking statements, whether as a result of new information, future events or results or otherwise. There can be no assurance that forward-looking statements will prove to be accurate, as actual results and future events could differ materially from those anticipated in such statements. Accordingly, readers should not place undue reliance on forward-looking statements.
The Company was incorporated under the laws of Alberta on November 22, 1983 and is listed on the TSX Venture Exchange (the "TSXV") as a Tier 2 life science issuer under the trading symbol "IPA". The Company's common shares were approved for listing on the NASDAQ Global Market ("Nasdaq") under the trading ticker symbol "IPA". Trading on Nasdaq commenced at market open on December 30, 2020. The address of the Company's head office is 3204 - 4464 Markham Street, Victoria, BC V8Z 7X8.
On November 23, 2020, the Company consolidated its issued and outstanding common shares on the basis of five pre-consolidation shares for one post-consolidation share (the "Consolidation"). All references to share and per share amounts in this MD&A have been retroactively restated to reflect the Consolidation.
IMMUNOPRECISE ANTIBODIES LTD.
MANAGEMENT DISCUSSION AND ANALYSIS
FOR THE NINE MONTHS ENDED JANUARY 31, 2022
ImmunoPrecise Antibodies Ltd. is a biotherapeutic, innovation-powered company that supports its business partners in their quest to discover and develop novel antibodies against a broad range of target classes and diseases. The Company offers a hybrid of services and programs with advanced platforms and technologies, dynamic scientists and business advisors - to optimize antibody discovery and development against rare and/or challenging epitopes.
The Company offers comprehensive support to its partners starting with customized project design, antigen preparation guided by computational analysis, an on-site vivarium, proprietary immunization services, a broad suite of discovery platforms, high-throughput characterizations, including functional screening, to facilitate lead candidate selection, lead optimization, antibody engineering and manufacturing, all under one contract.
The Company's depth of experience, innovative technologies, scientific rigor, and focus on quality provide superior one-stop service solutions. This also supports the Company in its goal to reduce the time and risk associated with conventional multi-vendor product development.
The Company has achieved organic revenue growth through market penetration and service diversification in the biologics contract research organization ("CRO") space, as well as accretive growth through strategic expansion of its operations into Europe, by acquiring and integrating innovative technologies and investing in research and development ("R&D").
The Company's capabilities include, but are not limited to, custom antigen modeling, design and manufacturing; proprietary B cell sorting, screening and sequencing; custom, immune and proprietary na ve phage display libraries production and screening; hybridoma discovery and production with multiplexed, high-throughput screening and single clone-picking; expertise with transgenic animals and multi-species antibody discovery; antibody characterization studies such as affinity measurements, functional assays, epitope mapping and binning; bi-specific, single domain (such as variable domain of the heavy chain "VHH", and variable new antigen receptor "VNAR" (shark)) antibody manufacturing; recombinant cloning and production of antibodies, protein and antibody downstream processing with purification of protein in gram scale levels including characterization and validation; transient and stable cell line generation; antibody engineering, optimization including humanization; and cryopreservation and cryostorage.
The Company's wholly owned subsidiaries, ImmunoPrecise Antibodies (Canada) Ltd. ("IPA Canada") and ImmunoPrecise Antibodies (Europe) B.V. (consisting of the former ModiQuest Research B.V. and U-Protein Express B.V.) ("IPA Europe"), have been designated as approved CROs for leading, transgenic animal platforms producing antibodies with human antigen binding domains, along with protein manufacturing. Through IPA Canada and IPA Europe, the Company has made strategic investments in R&D activities to develop proprietary technologies enabling the application of its B cell Select and DeepDisplay platforms to a broad range of species and strains, including transgenic animals.
IMMUNOPRECISE ANTIBODIES LTD.
MANAGEMENT DISCUSSION AND ANALYSIS
FOR THE NINE MONTHS ENDED JANUARY 31, 2022
Operations of the Company
The Company's operations are based in Utrecht and Oss, the Netherlands, Victoria, British Columbia, and Fargo, North Dakota.
The Company's global management, operating out of North America and Europe, is responsible for all global oversight into pipeline development, finances and accounting, sales and marketing, investor communications, and information technology. To support management and the Board of Directors in exercising oversight, the Company implemented an enterprise resource management system ("ERP") for marketing and sales automation and customer relationship management, as well as accounting and financial reporting, resource planning and project management. Comprehensive operational and management reporting capabilities were implemented to effectively support a geographically dispersed organization allowing managers access to the Company data globally.
The Company's head office is located in Victoria, British Columbia. The headquarters for the US operations is based in Fargo, North Dakota, and allows the Company to take advantage of a US location that has a significant and diverse economy with a strong history of supporting global life science companies. The site in Fargo was opened in 2018 and serves as the address of ImmunoPrecise Antibodies (ND) Ltd. and ImmunoPrecise Antibodies (USA) Ltd. and offers the potential for future growth plans in the United States.
IPA Canada operates from Victoria, British Columbia, performing custom antibody generation since its inception. The Company has sought to increase its capabilities at its Victoria location by adding equipment for protein purification and measuring protein binding kinetics and high-throughput label-free protein-protein interactions, enlarging the vivarium, and further developing and improving technologies such as its B cell Select platform.
Since the acquisitions of U-Protein Express B.V. ("UPE") and ModiQuest Research B.V. ("MQR") (now together named IPA Europe), the Company has focused on optimizing its cutting-edge technologies to support the development of novel therapeutic antibodies, bringing an expanded array of capabilities to partners in Europe, North America and the rest of the world. The former MQR team located in Oss added, among other capabilities, in depth expertise in in vitro antibody phage library generation and screening, as well as antibody characterization, including functionality and developability profiling, antibody optimization, including humanization, and antibody engineering to the Company's extensive service portfolio.
As of January 1, 2021, UPE merged with IPA Europe to form one legal entity. The former UPE team continues its operations in the biotechnology hub of Utrecht and has been operating in the recombinant protein community for close to twenty years. IPA's Utrecht site specializes in the manufacture of complex proteins and antibodies in a variety of formats, and from a range of mammalian cell types, using its proprietary expression platform rPEx . Their operations have enabled the successful support of over five thousand different programs for pharmaceutical and biotechnology industries as well as leading, academic institutions.
Research, Development and Therapeutic Discovery Program
CRO services are the main focus of the Company's business activities, though it also continues to develop an intellectual property portfolio of proprietary methods and physical assets through internal R&D, collaborations, acquisitions and in-licensing. The Company has invested strategically in the development and licensing of antibody discovery technologies and related intellectual property assets. These investments have been enhanced by internal discovery programs focused on novel therapeutic antibodies and vaccines in areas such as oncology, inflammation, neurodegenerative diseases, autoimmunity, atherosclerosis, and COVID-19. These programs diversify the nature of opportunities by which pharmaceutical partners may choose to engage the Company by enabling the in-licensing or sale of later-stage pre-clinical assets.
IMMUNOPRECISE ANTIBODIES LTD.
MANAGEMENT DISCUSSION AND ANALYSIS
FOR THE NINE MONTHS ENDED JANUARY 31, 2022
In 2019, the Company formed Talem Therapeutics LLC ("Talem"), based in Cambridge, Massachusetts, to support its internal and partnered therapeutic discovery programs, which includes a license for the use of Ligand Pharmaceuticals' OmniAb transgenic animals pursuant to a commercial platform license and services agreement dated October 30, 2019. Talem has the right to discover, develop and partner fully human antibodies from these animals. Talem offers strategic and selective partnerships with pharma companies using OmniAb transgenic animals or its alternative therapeutic antibody discovery capabilities available at IPA Canada and IPA Europe. The ability for investors to support individual assets or portfolios generates an asymmetrical opportunity for investments, while avoiding Company shareholder dilution. The depth and speed of the offerings enable Talem to customize each program and leverages the Company's expertise and technologies in the antibody discovery and development.
STRATEGY AND OUTLOOK
The Company's management team places an emphasis on initiatives designed to drive revenue, bolster internal assets and maximize shareholder value. The Company aims to continue to build on revenue and asset generation through internal development and well-informed, strategic acquisitions and joint ventures. The Company's strategy also includes growth through alliances and partnerships, within both its research (Talem) and service sectors, as well as potential new market sectors such as pre-clinical and clinical manufacturing.
The Company's objective is to continue growing as a preferred partner for therapeutic antibody researchers. Therefore, the Company's aim is to deliver a comprehensive and integrated continuum of technologically advanced and high-throughput data-driven protein and antibody services to its partners to enable them to bring novel therapies to the clinic faster. The Company intends to continue focusing on the development and refinement of its integrated end-to-end platform, which, when coupled with strong scientific know-how, can help partners navigate through the process of lead candidate advancement. The Company offers customized solutions for antibody discovery while providing details via the project management team to ensure partners have the project data they need, with the security measures required to ensure their peace of mind.
In summer 2022, the Company will move its Utrecht location from its current premises in the Life Science Incubator to new, larger premises within the Utrecht Science Park. In the new location the Company will significantly increase its capacity for protein manufacturing and related services.
In the second half of 2023, the Company will move its Oss location to a new state-of-the-art facility within the Pivot Park campus. The move will increase space by almost 30%.
Both expansions are a strategic commitment to the locations of IPA Europe and will enable the Company to significantly increase capacity, personnel and service offerings to serve the increasing market needs in Europe, North America and Asia.
The Company believes its strategy is supported by growing trends in pharma and finance. Large pharmaceutical companies continue to outsource research, with trends showing an increase on the reliance of external partners to improve the efficiency and cost of development, increase turnaround time, and access advanced and integrated expertise. A report by Objective Capital Partners dated July 3, 2019, titled "CRO Sector Fundamentals Remain Hot for M&A Consolidation" identified several major drivers of the CRO industry growth, including robust biopharmaceutical funding, accelerated drug approval rates, the growing number of clinical trials, and proliferation of biopharmaceutical companies without own internal research and clinical capabilities.
To streamline, many large pharmaceutical companies are limiting the number of external partners that can be contracted. This is particularly promising for those CROs that fill multiple niches in the discovery and manufacturing pipeline, as the Company believes it can do.
IMMUNOPRECISE ANTIBODIES LTD.
MANAGEMENT DISCUSSION AND ANALYSIS
FOR THE NINE MONTHS ENDED JANUARY 31, 2022
According to a report titled "Global and China Monoclonal Antibody Industry Report, 2019-2025" published in April 2019 on ResearchandMarkets.com, the key industry participants serving the monoclonal antibodies market are Novartis, Merck & Co., Amgen, AbbVie, Johnson & Johnson and Roche.
In May 2020, ResearchandMarkets.com stated in their report "Global Antibody Production Market (2020 to 2025) - Growth, Trends, and Forecasts" that investments by pharma and biotech companies in antibody R&D are expected to increase given the rising prevalence of cancer, autoimmune disease and other chronic diseases. Additionally, a piece on the website for Genetic Engineering & Biotechnology News titled "Antibody Discovery Looks over the Horizon" published on February 7, 2019, stated that antibodies are a mainstay in oncology as physicians move away from other types of therapies such as small molecules. In recent years, the success of key pipeline drugs in the immuno-oncology space have been a key component of the record high capital market funding for the biotechnology sector, according to Objective Capital Partners' report on the CRO sector fundamentals, as noted above.
The market for therapeutic antibodies was worth US$115 billion in 2018 and according to a study published in the Journal of Biomedical Science in January 2020, it is estimated that the human therapeutic antibody market will grow to US$300 billion in 2025. The biopharmaceuticals sector is the fastest growing pharma sector. While the sale of therapeutic antibodies increased by 93% from US$84 billion in 2014 to nearly US$163 billion in 2019, other recombinant protein therapeutics have remained unchanged over the same period, according to "The Therapeutic Monoclonal Antibody Product Market" published in October 2020, in BioProcess International. Companies are currently sponsoring clinical studies for more than 570 monoclonal antibodies. In recent years, the number of monoclonal antibody drugs approved for commercialization has proliferated, with the 100th monoclonal antibody approved by the United States Food and Drug Administration ("FDA") as of May 2021 (Nature Reviews Drug Discovery) and a further 17 investigational antibody therapeutics in regulatory review in either the United States or Europe as of June 2021 according to AntibodySociety.org.
The protein and antibody-related service and product market is expected to grow with a CAGR of 6.2% by 2027 to US$5.6 billion, according to GrandViewResearch.com. ResearchandMarkets.com expect the research antibody market size to reach US$5.9 billion by 2028, with a CAGR of 6.4%, with the majority driven by a rise in R&D initiatives by biopharmaceutical and biotechnology companies and government bodies.
There is an ongoing need for therapeutics to protect against COVID-19 even when a vaccine is available, as vaccines do not provide protection for all individuals. This is particularly true for immunocompromised individuals such as the elderly, cancer patients, individuals with HIV or those undergoing bone marrow and organ transplants, whose immune systems are too weak to mount an effective response upon vaccination. Without 100% protection, important segments of higher exposure risk populations will likely be left unprotected - namely frontline workers and those living in group care.
Therapeutic antibodies are providing breakthrough medicines for cancer, inflammation, autoimmune and infectious diseases due in part to their high on-target affinity and exquisite specificity making them highly efficacious with good safety profiles.
Technological advances in antibody discovery methods such as B cell sorting now enable the rapid and systematic generation of high-quality fully human antibodies from healthy donors, diseased patients, and transgenic animals. Furthermore, when therapeutic antibodies are combined into cocktails, they can provide unique protection against infectious diseases by working synergistically to neutralize pathogens via multiple mechanism of action engaged in concert, boosting potency beyond the sum of their individual components. Single antibodies are vulnerable to mutagenic escape and can be rendered ineffective by a single point mutation in the pathogen. In contrast, antibody cocktails may protect against mutagenic escape because they cover a larger epitope footprint on the pathogen's surface than possible with a single antibody, providing longer-lasting protection against emerging mutations.
IMMUNOPRECISE ANTIBODIES LTD.
MANAGEMENT DISCUSSION AND ANALYSIS
FOR THE NINE MONTHS ENDED JANUARY 31, 2022
The Company's diverse panel of anti-SARS-CoV-2 antibodies with therapeutic potential can be curated into synergistic cocktails, providing opportunities for out-licensing and sponsorship deals which the Company believes would enable it to respond quickly to emerging viral variants as well as formulation into bi- or multi-specifics. The Company has successfully completed pre-clinical studies in Syrian hamsters and could demonstrate powerful in vivo efficacy in both therapeutic and prophylactic settings.
On January 27, 2022, Talem, filed for patent protection of its PolyTope TATX-03 antibody cocktail via the PCT (Patent Cooperation Treaty) system (which has 154 member states) as well as national filings in the US, Taiwan, Argentina, and Paraguay, enabling the Company to pursue patent protection of the PolyTope TATX-03 cocktail in all sizeable potential markets. In the meantime, the PolyTope TATX-03 remaining non-clinical safety studies are expected to conclude in Q2 of CY2022. At the request of the FDA, the Company has prepared a comprehensive status update demonstrating the performance of PolyTope TATX-03 toward Omicron (B.1.1.529), and other variants of concern, for review. The Company expects that, upon completion of its ongoing studies, the data will enable the Company to file an Investigational New Drug ("IND") application in Q2/3 of CY2022. The approval of the FDA with respect to the IND application will be required prior to commencing first-in-human clinical studies.
The Company is presently manufacturing clinical batches of the fully human, lead monoclonal antibodies of its TATX-03 cocktail and aims to use the resulting data to support conversations with sponsors, potential partners, and funding agencies. The Company anticipates similar cocktail formulations, including its bi-specific, cocktail formulations, to also follow into pre-clinical testing in the near-term. As result, the Company anticipates that such developments will provide on-going opportunities for commercialization.
OVERALL PERFORMANCE AND LIQUIDITY
The Company continued to emphasize the value of technologically advanced discovery programs utilizing diverse animal repertoires and multiple technologies with unique advantages, while continuing to achieve organic revenue growth through market penetration and service diversification in the biologics CRO space. The Company achieved revenues of $4.8 million during the three months ended January 31, 2022, a 6.6% increase from 2021 revenues of $4.5 million. For the nine months ended January 31, 2022, the Company achieved revenues of $14.1 million, an 8.4% increase over 2021 revenues of $13.0 million.
The Company continues to expand its commitment to R&D initiatives aimed at introducing new technological capabilities through both internal development and external partnerships, including R&D projects related to COVID-19 and other internal programs. At Talem, the Company develops a diverse pipeline of pre-clinical programs with the objective to partner, out-license or sell for further clinical and commercial development. During the three and nine months ended January 31, 2022, the Company invested $1.8 million and $5.8 million, respectively, in R&D.
As of January 31, 2022, the Company had cash on hand of $33.0 million compared to $41.8 million as of April 30, 2021. The Company's internal forecast indicates the cash on hand is expected to sustain its existing operations, support its Nasdaq and TSXV on-going listing costs and satisfy its obligations for at least one year. The Company may need to raise additional capital to fund its strategic goals and there can be no assurances that sufficient funding, including adequate financing, will be available. The ability of the Company to arrange additional financing in the future depends, in part, on the prevailing market conditions and profitability of its operations.
IMMUNOPRECISE ANTIBODIES LTD.
MANAGEMENT DISCUSSION AND ANALYSIS
FOR THE NINE MONTHS ENDED JANUARY 31, 2022
RESULTS OF OPERATIONS
Comparison of the three months ended January 31, 2022 and 2021
| Three Months Ended January 31, | ||||||||||||||||
| (in thousands) | 2022 $ | 2021 $ | Change $ | Change % | ||||||||||||
| Project revenue | 4,073 | 3,323 | 750 | 22.6 | % | |||||||||||
| Product sales revenue | 465 | 1,190 | (725 | ) | -60.9 | % | ||||||||||
| Cryostorage revenue | 277 | 2 | 275 | 13750.0 | % | |||||||||||
| Total revenue | 4,815 | 4,515 | 300 | 6.6 | % |
The Company achieved revenue of $4.8 million during the three months ended January 31, 2022, a 6.6% increase from the three months ended January 31, 2021.
Project revenue of $4.1 million was $0.8 million, or 22.6%, higher than the same period last year. Growth is driven primarily by the Company's B cell Select platform, with expansion in both the number and size of projects under contract leading to revenue increases of $0.7 million.
Product sales during the three months ended January 31, 2022 totaled $0.5 million, a decrease of $0.7 million, or 60.9%, compared to the same period last year. The higher product sales during the three months ended January 31, 2021 relates to the Company's sale of its first internally generated therapeutic antibody asset. The Company achieved growth of catalog sales of $0.4 million during the three months ended January 31, 2022 as compared to the same period last year. Catalog products include antibodies, enzymes, enzyme activity assays, arthritis animal products, proteins, deiminated proteins, organoid growth factors and hybridoma licensing for research purposes.
| Three Months Ended January 31, | ||||||||||||||||
| (in thousands) | 2022 $ | 2021 $ | Change $ | Change % | ||||||||||||
| Gross profit | 2,586 | 3,562 | (976 | ) | -27.4 | % | ||||||||||
| % of total revenue | 54 | % | 79 | % |
Gross profit totaled $2.6 million during the three months ended January 31, 2022, compared to $3.6 million during the three months ended January 31, 2021. The gross profit margin for the three months ended January 31, 2022 is within management's expectations given the Company's consistent method of allocating overhead expense to cost of sales. During the three months ended January 31, 2021 the Company sold its first internally developed therapeutic antibody, the costs for which had been expensed as research in a prior year as required by IFRS. Additionally, gross profit during the three months ended January 31, 2021 was impacted by a correction related to the elimination of intercompany transactions. Further information about the correction can be found in the Summary of Quarterly Results. Excluding these items, gross profit as a percent of total revenue was 51% during the three months ended January 31, 2021.
IMMUNOPRECISE ANTIBODIES LTD.
MANAGEMENT DISCUSSION AND ANALYSIS
FOR THE NINE MONTHS ENDED JANUARY 31, 2022
| Three Months Ended January 31, | ||||||||||||||||
| (in thousands) | 2022 $ | 2021 $ | Change $ | Change % | ||||||||||||
| Advertising | 228 | 216 | 12 | 5.6 | % | |||||||||||
| Amortization and depreciation | 638 | 731 | (93 | ) | -12.7 | % | ||||||||||
| Asset impairment charge | 167 | - | 167 | N/A | ||||||||||||
| Bad debt recovery | 7 | (2 | ) | 9 | N/A | |||||||||||
| Consulting fees | 299 | 124 | 175 | 141.1 | % | |||||||||||
| Foreign exchange loss | (55 | ) | 96 | (151 | ) | N/A | ||||||||||
| Insurance | 510 | 204 | 306 | 150.0 | % | |||||||||||
| Interest and bank charges | 96 | 91 | 5 | 5.5 | % | |||||||||||
| Office and general | 224 | 624 | (400 | ) | -64.1 | % | ||||||||||
| Professional fees | 513 | 692 | (179 | ) | -25.9 | % | ||||||||||
| Rent | 44 | 57 | (13 | ) | -22.8 | % | ||||||||||
| Repairs and maintenance | 54 | 29 | 25 | 86.2 | % | |||||||||||
| Research and development | 1,820 | - | 1,820 | N/A | ||||||||||||
| Salaries and benefits | 1,789 | 1,074 | 715 | 66.6 | % | |||||||||||
| Share-based payments | 492 | 852 | (360 | ) | -42.3 | % | ||||||||||
| Telephone and utilities | 12 | 23 | (11 | ) | -47.8 | % | ||||||||||
| Travel | 55 | 12 | 43 | 358.3 | % | |||||||||||
| Total operating expenses | 6,893 | 4,823 | 2,070 | 42.9 | % |
Variances of note in the Company's expenses for the three months ended January 31, 2022 compared to the three months ended January 31, 2021 include:
IMMUNOPRECISE ANTIBODIES LTD.
MANAGEMENT DISCUSSION AND ANALYSIS
FOR THE NINE MONTHS ENDED JANUARY 31, 2022
Other Income / Expense
| Three Months Ended January 31, | ||||||||||||
| (in thousands) | 2022 $ | 2021 $ | Change $ | |||||||||
| Accretion | (21 | ) | (78 | ) | 57 | |||||||
| Grant income | 36 | - | 36 | |||||||||
| Subsidy income | - | 122 | (122 | ) | ||||||||
| Interest and other income | 160 | 12 | 148 | |||||||||
| Unrealized foreign exchange gain | 514 | - | 514 | |||||||||
| Total other income (expense) | 689 | 56 | 633 |
The Company recorded other income of $0.7 million during the three months ended January 31, 2022, compared to other income of $0.1 million during the three months ended January 31, 2021. The most noteworthy variance is the unrealized foreign exchange gain of $0.5 million compared to nil during the three months ended January 31, 2021, a result of currency revaluations of held US dollars at the current quarter-end exchange rate. There were no significant US dollars held as of January 31, 2021.
The Company recorded a net loss of $3.8 million during the three months ended January 31, 2022, compared to a net loss of $1.3 million for the three months ended January 31, 2021. The $2.5 million increased net loss is primarily due to the Company's investment in R&D and salaries and benefits to support the Company's strategic plans and operations.
Comparison of the nine months ended January 31, 2022 and 2021
| Nine Months Ended January 31, | ||||||||||||||||
| (in thousands) | 2022 $ | 2021 $ | Change $ | Change % | ||||||||||||
| Project revenue | 12,652 | 11,328 | 1,324 | 11.7 | % | |||||||||||
| Product sales revenue | 1,177 | 1,700 | (523 | ) | -30.8 | % | ||||||||||
| Cryostorage revenue | 296 | 7 | 289 | 4128.6 | % | |||||||||||
| Total revenue | 14,125 | 13,035 | 1,090 | 8.4 | % |
The Company achieved revenue of $14.1 million during the nine months ended January 31, 2022, an 8.4% increase from the nine months ended January 31, 2021. The Company achieved revenue growth across all three operating sites in Victoria, Oss, and Utrecht.
Project revenue growth is driven primarily by the Company's B cell Select platform, which increased by $1.5 million compared to the nine months ended January 31, 2021.
The Company achieved growth of catalog product sales of $0.6 million during the nine months ended January 31, 2022. Product sales during the nine months ended January 31, 2021 reflect the sale of an internally generated therapeutic antibody asset for $1.2 million, resulting in a net decrease in product sales of $0.5 million compared to the prior year.
IMMUNOPRECISE ANTIBODIES LTD.
MANAGEMENT DISCUSSION AND ANALYSIS
FOR THE NINE MONTHS ENDED JANUARY 31, 2022
| Nine Months Ended January 31, | ||||||||||||||||
| (in thousands) | 2022 $ | 2021 $ | Change $ | Change % | ||||||||||||
| Gross profit | 7,667 | 8,761 | (1,094 | ) | -12.5 | % | ||||||||||
| % of total revenue | 54 | % | 67 | % |
Gross profit totaled $7.7 million during the nine months ended January 31, 2022, compared to $8.8 million during the nine months ended January 31, 2021. The gross profit margin for the nine months ended January 31, 2022 is within management's expectations given the Company's consistent method of allocating overhead costs to cost of sales. During the nine months ended January 31, 2021, the Company sold its first internally developed therapeutic antibody, the costs for which had been expensed as research in a prior year as required by IFRS. Excluding the effect of this sale, gross profit as a percent of total revenue was 64% for the nine months ended January 31, 2021.
| Nine Months Ended January 31, | ||||||||||||||||
| (in thousands) | 2022 $ | 2021 $ | Change $ | Change % | ||||||||||||
| Advertising | 589 | 505 | 84 | 16.6 | % | |||||||||||
| Amortization and depreciation | 1,948 | 2,125 | (177 | ) | -8.3 | % | ||||||||||
| Asset impairment charge | 167 | - | 167 | N/A | ||||||||||||
| Bad debt recovery | (17 | ) | (23 | ) | 6 | N/A | ||||||||||
| Consulting fees | 650 | 318 | 332 | 104.4 | % | |||||||||||
| Foreign exchange loss | (16 | ) | 142 | (158 | ) | N/A | ||||||||||
| Insurance | 1,470 | 301 | 1,169 | 388.4 | % | |||||||||||
| Interest and bank charges | 258 | 398 | (140 | ) | -35.2 | % | ||||||||||
| Management fees | - | 269 | (269 | ) | -100.0 | % | ||||||||||
| Office and general | 748 | 980 | (232 | ) | -23.7 | % | ||||||||||
| Professional fees | 1,135 | 1,113 | 22 | 2.0 | % | |||||||||||
| Rent | 114 | 147 | (33 | ) | -22.4 | % | ||||||||||
| Repairs and maintenance | 161 | 184 | (23 | ) | -12.5 | % | ||||||||||
| Research and development | 5,787 | 1,358 | 4,429 | 326.1 | % | |||||||||||
| Salaries and benefits | 4,633 | 3,925 | 708 | 18.0 | % | |||||||||||
| Share-based payments | 2,297 | 1,426 | 871 | 61.1 | % | |||||||||||
| Telephone and utilities | 35 | 51 | (16 | ) | -31.4 | % | ||||||||||
| Travel | 169 | 42 | 127 | 302.4 | % | |||||||||||
| Total operating expenses | 20,128 | 13,261 | 6,867 | 51.8 | % |
IMMUNOPRECISE ANTIBODIES LTD.