Full Press Release Details
Durable royalties portfolio generated $58.4 million in revenue for the fourth quarter and $250.3 million for the full year
IST achieved U.S. net product sales of $33.9 million for the fourth quarter and $119.2 million for the full year, representing 47% year-over-year growth
IST product portfolio strengthened with U.S. FDA approval of NUZOLVENCE®, a first-in-class treatment for uncomplicated urogenital gonorrhea
$125 million share repurchase program initiated in the fourth quarter
BURLINGAME, Calif.--(BUSINESS WIRE)--Innoviva, Inc. (NASDAQ: INVA) (“Innoviva” or the “Company”), a diversified biopharmaceutical company with a core royalties portfolio, a leading critical care and infectious disease platform known as Innoviva Specialty Therapeutics (“IST”), and a portfolio of strategic investments in healthcare assets, today reported financial results for the fourth quarter and full year ended December 31, 2025, and highlighted select corporate progress and achievements.
“2025 marked an excellent year for Innoviva, demonstrating strength across all areas of our business, with 15% revenue growth to over $400 million and net income exceeding $270 million. Our royalty business continued to provide stable and resilient cash flow, while IST generated 47% year-over-year U.S. sales growth to $119 million,” said Pavel Raifeld, Chief Executive Officer of Innoviva. “We expanded our commercial portfolio with the successful mid-2025 launch of ZEVTERA in the U.S., received nominations for two of our products for the prestigious 2025 Prix Galien USA Award, and ended the year on an exciting note with the FDA approval of our fifth product, NUZOLVENCE, a single-dose oral treatment for uncomplicated urogenital gonorrhea that addresses a critical public health challenge in light of the global rise of gonococcal drug resistance. We are excited about our growth prospects and anticipate $150 million or more in IST U.S. net product sales in 2026.”
“Our portfolio of strategic assets remains a key platform for long-term growth and differentiation, demonstrated by significant advances and value creation at Armata Pharmaceuticals. Overall, we remain a well-capitalized company with multiple value-accretive capital deployment opportunities in our current business, novel assets, and capital strategies, including a recently announced $125 million share repurchase program. We look forward to multiple inflection points across Innoviva’s portfolio in the year ahead,” concluded Mr. Raifeld.
Financial Highlights
Key Business and R&D Highlights
About Innoviva
Innoviva is a diversified biopharmaceutical company with a core royalties portfolio, a leading critical care and infectious disease platform known as Innoviva Specialty Therapeutics (“IST”), and a portfolio of strategic investments in healthcare assets. Innoviva’s royalty portfolio includes respiratory assets partnered with Glaxo Group Limited (“GSK”). Innoviva is entitled to receive royalties from GSK on sales of RELVAR®/BREO®ELLIPTA®and ANORO®ELLIPTA®. Innoviva’s critical care and infectious disease assets under the IST platform include GIAPREZA®(angiotensin II) for increasing blood pressure in adults with septic or other distributive shock, XACDURO®(sulbactam for injection; durlobactam for injection), co-packaged for intravenous use for the treatment of adults with hospital-acquired and ventilator-associated bacterial pneumonia caused by susceptible strains ofAcinetobacterbaumannii-calcoaceticus, XERAVA®(eravacycline) for the treatment of complicated intra-abdominal infections in adults, ZEVTERA (ceftobiprole), an advanced-generation cephalosporin antibiotic licensed from Basilea Pharmaceutica International Ltd, Allschwil, and NUZOLVENCE® (zoliflodacin), approved by the FDA for the oral treatment of uncomplicated urogenital gonorrhea in adults and pediatric patients 12 years of age and older weighing at least 35 kg. For more information about Innoviva, go towww.inva.com. For information about Innoviva Specialty Therapeutics, go towww.innovivaspecialtytherapeutics.com.
ANORO®, RELVAR®and BREO®are trademarks of the GSK group of companies. ZEVTERA is a trademark of Basilea Pharmaceutica Ltd, Allschwil.
Forward Looking Statements
This press release contains certain “forward-looking” statements as that term is defined in the Private Securities Litigation Reform Act of 1995 regarding, among other things, statements relating to goals, plans, objectives, and future events. Innoviva intends such forward-looking statements to be covered by the safe harbor provisions for forward-looking statements contained in Section 21E of the Securities Exchange Act of 1934 and the Private Securities Litigation Reform Act of 1995. The words “anticipate”, “expect”, “goal”, “intend”, “objective”, “opportunity”, “plan”, “potential”, “target” and similar expressions are intended to identify such forward-looking statements. Such forward-looking statements involve substantial risks, uncertainties, and assumptions. These statements are based on the current estimates and assumptions of the management of Innoviva as of the date of this press release and are subject to known and unknown risks, uncertainties, changes in circumstances, assumptions and other factors that may cause the actual results of Innoviva to be materially different from those reflected in the forward-looking statements. Important factors that could cause actual results to differ materially from those indicated by such forward-looking statements include, among others, risks related to: expected cost savings; lower than expected future royalty revenue from respiratory products partnered with GSK; the commercialization of RELVAR®/BREO®ELLIPTA®, ANORO®ELLIPTA®, GIAPREZA®, XERAVA®, XACDURO®, ZEVTERA®and NUZOLVENCE®in the jurisdictions in which these products have been approved; the strategies, plans and objectives of Innoviva (including Innoviva’s growth strategy and corporate development initiatives); the timing, manner, and amount of potential capital returns to shareholders; the status and timing of clinical studies, data analysis and communication of results; the potential benefits and mechanisms of action of product candidates; expectations for product candidates through development and commercialization; the timing of regulatory approval of product candidates; and projections of revenue, expenses and other financial items; the timing, manner and amount of capital deployment, including potential capital returns to stockholders; and risks related to the Company’s growth strategy. Other risks affecting Innoviva are described under the headings “Risk Factors” and “Management’s Discussion and Analysis of Financial Condition and Results of Operations” contained in Innoviva’s Annual Report on Form 10-K for the year ended December 31, 2025 and Quarterly Reports on Form 10-Q, which are on file with the Securities and Exchange Commission (“SEC”) and available on the SEC’s website atwww.sec.gov. Past performance is not necessarily indicative of future results. No forward-looking statements can be guaranteed, and actual results may differ materially from such statements. Given these uncertainties, you should not place undue reliance on these forward-looking statements. The information in this press release is provided only as of the date hereof, and Innoviva assumes no obligation to update its forward-looking statements on account of new information, future events or otherwise, except as required by law.
| INNOVIVA, INC. | |||||||||||||||||
| Condensed Consolidated Statements of Income | |||||||||||||||||
| (in thousands, except per share data) | |||||||||||||||||
| (Unaudited) | |||||||||||||||||
| Three Months Ended | Year Ended | ||||||||||||||||
| December 31, | December 31, | ||||||||||||||||
| 2025 | 2024 | 2025 | 2024 | ||||||||||||||
| Revenue: | |||||||||||||||||
| Royalty revenue, net (1) | $ | 54,896 | $ | 62,520 | $ | 236,479 | $ | 241,733 | |||||||||
| Net product sales | 59,064 | 28,935 | 172,130 | 97,492 | |||||||||||||
| License and other revenue | 653 | 351 | 2,719 | 19,486 | |||||||||||||
| Total revenue | 114,613 | 91,806 | 411,328 | 358,711 | |||||||||||||
| Cost of products sold (inclusive of amortization of inventory fair value adjustments) | 32,309 | 7,165 | 77,384 | 36,598 | |||||||||||||
| Amortization of acquired intangible assets | 6,637 | 6,511 | 26,277 | 25,902 | |||||||||||||
| Gross profit | 75,667 | 78,130 | 307,667 | 296,211 | |||||||||||||
| Operating expenses: | |||||||||||||||||
| Selling, general and administrative | 32,124 | 31,326 | 113,318 | 115,690 | |||||||||||||
| Research and development | 4,555 | 3,665 | 30,604 | 13,654 | |||||||||||||
| Total operating expenses | 36,679 | 34,991 | 143,922 | 129,344 | |||||||||||||
| Income from operations | 38,988 | 43,139 | 163,745 | 166,867 | |||||||||||||
| Changes in fair values of equity method investments, net | 111,149 | (21,256 | ) | 141,433 | (64,253 | ) | |||||||||||
| Changes in fair values of equity and long-term investments, net | 42,669 | 1,666 | 20,160 | (59,161 | ) | ||||||||||||
| Interest and dividend income | 6,151 | 5,768 | 21,086 | 19,141 | |||||||||||||
| Interest expense | (3,309 | ) | (4,749 | ) | (16,698 | ) | (22,209 | ) | |||||||||
| Other expense, net | (612 | ) | 126 | (2,864 | ) | (2,997 | ) | ||||||||||
| Income before income taxes | 195,036 | 24,694 | 326,862 | 37,388 | |||||||||||||
| Income tax expense | (30,883 | ) | (4,362 | ) | (55,697 | ) | (13,996 | ) | |||||||||
| Net income | $ | 164,153 | $ | 20,332 | $ | 271,165 | $ | 23,392 | |||||||||
| Net income per share: | |||||||||||||||||
| Basic | $ | 2.19 | $ | 0.32 | $ | 4.02 | $ | 0.37 | |||||||||
| Diluted | $ | 1.94 | $ | 0.26 | $ | 3.30 | $ | 0.36 | |||||||||
| Shares used to compute net income per share: | |||||||||||||||||
| Basic | 74,796 | 62,626 | 67,395 | 62,726 | |||||||||||||
| Diluted | 85,264 | 84,200 | 84,760 | 74,187 |
| (1) Total net revenue is comprised of the following (in thousands): | |||||||||||||||||
| Three Months Ended | Year Ended | ||||||||||||||||
| December 31, | December 31, | ||||||||||||||||
| 2025 | 2024 | 2025 | 2024 | ||||||||||||||
| (unaudited) | (unaudited) | ||||||||||||||||
| Royalties | $ | 58,351 | $ | 65,975 | $ | 250,302 | $ | 255,556 | |||||||||
| Amortization of capitalized fees | (3,455 | ) | (3,455 | ) | (13,823 | ) | (13,823 | ) | |||||||||
| Royalty revenue, net | $ | 54,896 | $ | 62,520 | $ | 236,479 | $ | 241,733 |
| INNOVIVA, INC. | ||||||
| Condensed Consolidated Balance Sheets | ||||||
| (in thousands) | ||||||
| (unaudited) | ||||||
| December 31 | ||||||
| 2025 | 2024 | |||||
| Assets | ||||||
| Cash and cash equivalents | $ | 550,941 | $ | 304,964 | ||
| Royalty and product sale receivables | 93,317 | 86,366 | ||||
| Inventory | 39,172 | 33,725 | ||||
| Prepaid expense and other current assets | 28,358 | 21,719 | ||||
| Current portion of ISP Fund investments | 15,727 | 107,532 | ||||
| Property and equipment, net | 1,555 | 514 | ||||
| Equity method and equity and long-term investments | 598,223 | 393,957 | ||||
| Capitalized fees | 56,138 | 69,961 | ||||
| Right-of-use assets | 10,929 | 2,453 | ||||
| Goodwill | 17,905 | 17,905 | ||||
| Intangible assets | 182,156 | 208,433 | ||||
| Deferred tax assets, net | — | 12,054 | ||||
| Other assets | 40,744 | 41,477 | ||||
| Total assets | $ | 1,635,165 | $ | 1,301,060 | ||
| Liabilities and stockholders’ equity | ||||||
| Other current liabilities | $ | 43,808 | $ | 39,507 | ||
| Accrued interest payable | 1,618 | 3,422 | ||||
| Deferred revenue | 4,270 | 1,126 | ||||
| Convertible senior notes, due 2025, net | — | 192,028 | ||||
| Convertible senior notes, due 2028, net | 257,731 | 256,316 | ||||
| Deferred tax liabilities, net | 31,793 | — | ||||
| Income tax payable, long term | 57,013 | 53,227 | ||||
| Other long term liabilities | 66,091 | 64,275 | ||||
| Stockholders’ equity | 1,172,841 | 691,159 | ||||
| Total liabilities and stockholders’ equity | $ | 1,635,165 | $ | 1,301,060 |
| INNOVIVA, INC. | |||||||
| Cash Flows Summary | |||||||
| (in thousands) | |||||||
| (unaudited) | |||||||
| Year Ended December 31, | |||||||
| 2025 | 2024 | ||||||
| Net cash provided by operating activities | $ | 196,930 | $ | 188,690 | |||
| Net cash provided by (used in) investing activities | 40,496 | (63,786 | ) | ||||
| Net cash provided by (used in) financing activities | 8,551 | (13,453 | ) | ||||
| Net change | $ | 245,977 | $ | 111,451 | |||
| Cash and cash equivalents at beginning of period | 304,964 | 193,513 | |||||
| Cash and cash equivalents at end of period | $ | 550,941 | $ | 304,964 |