Full Press Release Details
InMed Announces Successful Completion of Pharmacokinetic
Studies in Large Animal Model for its Alzheimer's Disease Candidate INM-901
Vancouver, British Columbia - November
18, 2025 - InMed Pharmaceuticals Inc. (NASDAQ: INM) ("InMed" or the "Company"), a pharmaceutical company
developing a pipeline of proprietary small-molecule drug candidates for diseases with high unmet medical need, today announced the successful
completion of pharmacokinetic ("PK") studies in large animal models for its Alzheimer's disease candidate INM-901.
This marks the first preclinical study in which
the oral formulation of INM-901 was administered in large animals. The results provide additional data in guiding decisions in the design
of a human Phase 1 clinical trial program.
Positive PK and Neurological Assessment Results
Over a seven-day dosing period, the studies demonstrated
robust bioavailability in in vivo models. INM-901 achieved what is anticipated to be therapeutic levels of systemic exposure, supporting
its potential utility in neurodegenerative disorders such as Alzheimer's disease.
In addition, neurological assessments evaluating
general attitude, behavior, and motor function revealed no adverse neural or behavioral effects, reinforcing the compound's favorable
profile and supporting its continued advancement toward first-in-human clinical trials.
In parallel, InMed has completed additional chemistry,
manufacturing, and controls ("CMC") development to scale the INM-901 manufacturing process in preparation for Investigational
New Drug ("IND")-enabling studies and regulatory interaction with the Food and Drug Administration ("FDA').
Dr. Eric Hsu, Senior Vice President, Preclinical
Research and Development at InMed, commented, "The successful completion of our first large animal PK study is very encouraging
for the INM-901 program. The data supports the clinical applicability of our INM-901 oral formulation and provides important insights
as we plan and design our IND-enabling studies and Phase 1 clinical trials. Furthermore, the neurological assessments strengthen our confidence
in the compound's overall safety profile."
Next Development Steps:
InMed Pharmaceuticals
is a pharmaceutical drug development company focused on developing a pipeline of proprietary small molecule drug candidates targeting
the CB1/CB2 receptors. InMed's pipeline consists of three separate programs in the treatment of Alzheimer's, ocular and dermatological
indications. For more information, visit www.inmedpharma.com.
Vice President, Investor Relations
and Corporate Communications
Cautionary Note Regarding Forward-Looking Information:
This news release contains "forward-looking
information" and "forward-looking statements" (collectively, "forward-looking information") within the meaning
of applicable securities laws. Forward-looking statements are frequently, but not always, identified by words such as "expects",
"anticipates", "believes", "intends", "potential", "possible", "would"
and similar expressions. Such statements, based as they are on current expectations of management, inherently involve numerous risks,
uncertainties and assumptions, known and unknown, many of which are beyond our control. Forward-looking information is based on management's
current expectations and beliefs and is subject to a number of risks and uncertainties that could cause actual results to differ materially
from those described in the forward-looking statements. Without limiting the foregoing, forward-looking information in this news release
includes, but is not limited to, statements about: the efficacy of INM-901; the favorable bioavailability profile of INM-901 oral formulation;
planning and preparation for pre-IND meeting with the FDA; positive results demonstrating robust bioavailability of INM-901; no adverse
neural or behavioral effects using INM-901; the clinical applicability of our INM-901 oral formulation; INM-901's overall safety
profile and next development steps including advancing CMC, dose ranging and GLP studies.
Additionally, there are known and unknown risk
factors which could cause InMed's actual results, performance, or achievements to be materially different from any future results,
performance or achievements expressed or implied by the forward-looking information contained herein. A complete discussion of the risks
and uncertainties facing InMed's stand-alone business is disclosed in InMed's Annual Report on Form 10-K and other filings
with the Securities and Exchange Commission on www.sec.gov.
All forward-looking information herein is qualified
in its entirety by this cautionary statement, and InMed disclaims any obligation to revise or update any such forward-looking information
or to publicly announce the result of any revisions to any of the forward-looking information contained herein to reflect future results,
events or developments, except as required by law.