InfuSystem Holdings, Inc. 31700 Research Park Drive Madison Heights, MI 48071 248-291-1210 Wednesday

Wednesday, March 9, 2016

INFUSYSTEM HOLDINGS, INC. REPORTS FOURTH QUARTER AND YEAR END 2015 FINANCIAL RESULTS

10% Net Collected Revenue Growth and Increases AEBITDA Margin to 26% for 2015

MADISON HEIGHTS, MICHIGAN, March 9, 2016 InfuSystem Holdings, Inc. (NYSE MKT: INFU), a leading national provider of infusion pumps and related services

for the healthcare industry in the United States and Canada, reported financial results today for the fourth quarter and full year ended December 31, 2015.

Full Year 2015 Highlights:

Management Discussion

Eric K. Steen, chief executive officer of InfuSystem, said, We met our full year 2015 guidance of double digit net collected revenue growth, defined as

net revenues less bad debt, and achieved AEBITDA of $18.8 million, or 26% of net revenue. Our other 2015 accomplishments included reducing our interest rate to below 3% with our new Chase credit facility, the Ciscura Holding Company, Inc.,

( Ciscura ) acquisition, the opening of our new service center in Georgia, increasing our payor networks under contract from approximately 270 at the beginning of the year to over 340 at year end, expanding our pump fleet to over 61,000

and our continued expansion of our information technology offerings to the market place. All of this makes us a stronger company - financially and competitively - as we head into 2016.

Mr. Steen continued We ended on a strong note with fourth quarter net revenue growth of 20%, primarily driven by a 16% increase in rental revenue and

product sales increasing by 54%. Looking at our recurring rental revenue on the same basis, for the fourth quarter of 2015, Net Collected Rental Revenue increased 14% to $15.5 million. For the full year 2015 Net Collected Rental Revenue increased

12% to $59.3 million. We are pleased with the double-digit rental growth for both the fourth quarter and the full year. All of this led us to achieve another solid profitable fourth quarter and full year.

We are particularly pleased with the significant growth of our electronic connectivity initiative. At this time last year, we were electronically

connected through EMR integrations with 25 oncology infusion centers throughout the U.S. and at December 31, 2015, we were connected with 75 infusion centers, an increase of 200%. We are pleased with the successful EMR platform integrations

that include EPIC, Cerner, Varian and Altos and we are encouraged about how well our newly developed EXPRESS PC and iPad order entry system is being received. We have already converted over 100 clinic facilities to this new system. We firmly believe

this is a significant differentiator versus our competitors. Our customers have made it clear to us that they greatly appreciate the technology solutions that we provide to eliminate the duplication of medical records, transfer the billings and

collections processes from their staff to our software platform, and automatically place orders for new pumps as needed. This is clearly a win/win for both parties, as both our EMR integration solution InfuConnect and our PC and iPad

based EXPRESS allow our customers to drive operating efficiencies throughout their organization.

Mr. Steen concluded, We remain committed to

our growth strategy to continue to expand our rental pump fleet and to consider opportunistic asset acquisitions that meet our financial criteria and can be integrated quickly and efficiently just as we did with the Ciscura acquisition in

2015. During 2015, we added over 9,200 infusion pumps to our fleet, an investment of $10.5 million, and continued to gain traction in our Pain Management initiatives. The progress we made in 2015 is a testament to the hard

work, commitment and creativity of our employees to do the job and to do it well. We successfully executed on a key strategic initiative to drive profitable growth in 2015 and we look to extend

that momentum into 2016 and beyond.

Full Year 2015 Results

Revenue for the full year ended December 31, 2015 was $72.1 million, a 9% increase over 2014. Rental revenue increased 10%; revenue from product sales

decreased 2% from 2014. Gross profit as a percentage of revenues remained consistent with the same 12-month period in 2014 at 71%.

Net Collected Rental

Revenue was $59.3 million, an increase of 12%, compared to last year s $53.0 million. Bad debt decreased $0.5 million compared to the prior year from 10% of Rental Revenue to 8% of Rental Revenue in 2015. This change is the result of our

increased number of third-party payor contracts that are now being billed at in-network rates with lower rates of bad debt whereby previous insurance billings were billed at higher out-of-network rates and higher rates of bad debt.

Year-to-date selling and marketing expenses were up $0.7 million, or 7% to $10.4 million, compared to $9.7 million in the same prior year period. As a

percentage of total revenues, selling and marketing expenses remained consistent at approximately 15% for the comparable 2014 period, continuing our leverage on selling expenses.

General and administrative ( G&A ) expenses year-to-date were up $3.8 million, or 19%, to $23.8 million, compared to $20.0 million in the same

prior year period. The increase in G&A expenses versus the same prior year period was mainly attributable to increases in spending on information technology ( IT ) and Pain Management initiatives of $0.9 million, increases in

compensation and personnel of $1.9 million, increases in stock-based compensation of $0.4 million and $0.7 million in deal costs related to our acquisition, transition and integration of Ciscura offset by savings in other G&A categories.

Net income for the year increased 12% to $3.7 million, or $0.16 per diluted share, versus $3.4 million, or $0.15 per share, in the prior year. Adjusted net

income for the year, adding back integration costs associated with the Ciscura acquisition and other income and expenses was $5.3 million, or $0.23 per diluted share, compared to $3.4 million, or $0.15 per diluted share, in the same prior year

For the twelve months ended December 31, 2015, Adjusted EBITDA increased $2.7 million, or 17% to $18.8 million, compared to $16.1 million in

the same prior year period despite the increased investments in IT, Pain Management, compensation and personnel costs and stock compensation - all totaling $3.9 million. The Company utilizes Adjusted EBITDA as a means to measure its operating

performance. A reconciliation table for Adjusted EBITDA, a non-GAAP measure, to net income can be found in the appendix.

Fourth Quarter Results

Net Revenue in the fourth quarter of 2015 was $19.5 million, an increase of $3.3 million, or 20%, compared to the same quarter ended December 31, 2014.

During the period, net revenue from rentals was $16.9 million, an increase of $2.4 million, or 16%, compared to the same prior year period. Product sales during the quarter totaled $2.6 million, an increase of $0.9 million, or 54.0%, compared to

$1.7 million in the fourth quarter of 2014.

Selling and marketing expenses were $2.3 million, an increase of 18%, compared to $2.0 million for the three

months ended December 31, 2014, but remained consistent at 12% as a percentage of revenue. This increase was largely attributable to increased efforts in the marketing area and additional headcount as a result of our acquisition of Ciscura.

G&A expenses were $6.1 million, an increase of 16%, compared to $5.3 million for the quarter ended December 31, 2014. As a percentage of

revenue, G&A expenses decreased slightly from 32% to 31% in the fourth quarter of 2015. The increase in G&A expenses versus the same prior year period was mainly attributable to increases in spending on IT of $0.6 million and compensation

and personnel of $0.2 million.

Net income in the fourth quarter increased 94% to $2.0 million, or $0.09 per diluted share, compared to net income of $1.0

million, or $0.05 per diluted share, for the fourth quarter of last year.

For the fourth quarter, Adjusted EBITDA increased $1.4 million, or 30% to $6.0

million, compared to $4.6 million in the same prior year period. The Company utilizes Adjusted EBITDA as a means to measure its operating performance. A reconciliation table for Adjusted EBITDA, a non-GAAP

measure, to net income can be found in the appendix this press release.

Net cash provided by operations for the full year ended December 31, 2015 was $7.1 million compared to net cash provided of $7.3 million for the prior

As of December 31, 2015, the Company had cash and cash equivalents of $0.8 million and $9.9 million of availability on its revolving line-of-credit compared to $0.5 million of cash and cash equivalents and $6.6 million of availability on its revolving line-of-credit as of December 31, 2014. Total debt less cash on hand ( Net Debt ) as of December 31, 2015 was $34.2 million, including $6.2 million as a result of the Ciscura

acquisition, compared to the previous fiscal year of $25.0 million.

Management Discussion

We will continue to make investments that will allow us to gain market share and drive both top- and bottom-line results. During 2015 we invested more than $5 million in IT and over $10 million in our infusion pump fleet, while maintaining liquidity at the $10 million level, said Jonathan P. Foster, chief

financial officer. During the year, we refinanced our debt to an all-time low rate; incurred an early extinguishment of debt of $1.6 million and nearly offset these costs with savings on interest

expense of $1.4 million in the first year. The strong cash flow characteristics of our business, afford us the confidence to responsibly service the debt and grow our business profitably.

The Company issues guidance of high single

digit net collected revenue growth for 2016. It is important to note that the Company s Form 10-K for the year ended December 31, 2015, includes comments regarding the recent announcements by the Centers for Medicare and Medicaid Services

( CMS ) and seasonality.

The Company will conduct a conference call for investors on Wednesday, March 9, 2016 at 11:00 a.m. Eastern Time to discuss fourth quarter and year end

performance and results. Eric K. Steen, chief executive officer, Jan Skonieczny, chief operating officer, and Jonathan P. Foster, chief financial officer, will discuss the Company s financial performance and answer questions from the financial

community. To participate in this call, please dial in toll-free 800-446-1671 and use the confirmation number 41752008. The

release will be available on most financial websites. Additionally, a Web replay will be available on the Company s website for 30 days.

This press release contains

information prepared in conformity with GAAP as well as non-GAAP information. It is management s intent to provide non-GAAP financial information in order to

enhance readers understanding of its consolidated financial information as prepared in accordance with GAAP. This non-GAAP information should be considered by the reader in addition to, but not instead

of, the financial statements prepared in accordance with GAAP. Each non-GAAP financial measure and the corresponding GAAP financial measures are presented so as to not imply that more emphasis should be placed

on the non-GAAP measure. The non-GAAP financial information presented may be determined or calculated differently by other companies. Additional information about non-GAAP financial measures and a reconciliation of those measures to the most directly comparable GAAP measures are included later in this release.

About InfuSystem Holdings, Inc.

InfuSystem Holdings, Inc. is a leading provider of infusion pumps and related services to hospitals, oncology practices and other alternate site healthcare

providers. Headquartered in Madison Heights, Michigan, the Company delivers local, field-based customer support and also operates Centers of Excellence in Michigan, Kansas, California, Texas, Georgia and

Ontario, Canada. The Company s stock is traded on the NYSE MKT under the symbol INFU.

Forward-Looking Statements

Certain statements contained in this press release are forward-looking statements within the meaning of Section 27A of the Securities Act of 1933,

as amended (the Securities Act ) and Section 21E of the Securities Exchange Act of 1934, as amended (the Exchange Act ). The words believe, may, will, estimate,

continue, anticipate, intend, should, plan, expect, strategy, future, likely, variations of such words, and other similar expressions, as

they relate to the Company, are intended to identify forward-looking statements. However, the absence of these words or similar expressions does not mean that a statement is not

forward-looking. In connection with the safe harbor provisions of the Private Securities Litigation Reform Act of 1995, the Company is identifying certain factors that could cause actual results to

differ, perhaps materially, from those indicated by these forward-looking statements. Those factors, risks and uncertainties include, but are not limited to, potential changes in overall healthcare reimbursement, including the Centers for Medicare

and Medicaid Services competitive bidding, sequestration, concentration of customers, increased focus on early detection of cancer, competitive treatments, dependency on Medicare Supplier Number, availability of chemotherapy drugs, global financial

conditions, changes and enforcement of state and federal laws, natural forces, competition, dependency on suppliers, risks in acquisitions & joint ventures, U.S. Healthcare Reform, relationships with healthcare professionals and organizations,

technological changes related to infusion therapy, dependency on websites and intellectual property, the ability of the Company to successfully integrate acquired businesses, dependency on key personnel, dependency on banking relations and

covenants, and other risks associated with our common stock, as well as any litigation to which the Company may be involved in from time to time; and other risk factors as discussed in the Company s annual report on Form 10-K for the year ended December 31, 2015 and in other filings made by the Company from time to time with the Securities and Exchange Commission, including subsequent quarterly reports on our Form 10-Q. Our annual report on Form 10-K is available on the SEC s EDGAR website at www.sec.gov, and a copy may also be obtained by contacting the Company. All

forward-looking statements made in this press release speak only as of the date hereof. We do not intend, and do not undertake any obligation, to update any

forward-looking statements to reflect future events or circumstances after the date of such statements.

Additional information about InfuSystem Holdings, Inc. is available at www.infusystem.com.

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