Full Press Release Details
to Present Update on Lead ACTengine Program IMA203 Targeting PRAME at the
Society for Immunotherapy of Cancer's 36th Annual Meeting
Texas and Tuebingen, Germany, November 1,
2021 - Immatics N.V. (NASDAQ: IMTX, "Immatics"),
a clinical-stage biopharmaceutical company active in the discovery and development of T cell-redirecting cancer immunotherapies, today
announced that the company will provide an update on its ACTengine IMA203 trial in a late-breaking oral presentation
as well as an update on Immatics' next-generation CD8ab TCR-T approach at the 36th
Annual Meeting of the Society for Immunotherapy of Cancer's (SITC). The conference will take place, both in person and virtually,
from November 10 - 14, 2021.
Today, SITC announced
presentation titles and timings as follows:
1a Clinical Data Update:
Title: Safety and anti-tumor activity of TCR-engineered autologous, PRAME-directed T cells across multiple advanced solid cancers
at low doses - clinical update on the ACTengine IMA203 trial
Wermke, MD, Coordinating Investigator of Immatics ACTengine trials in Germany and Head of the Early Clinical Trial
Unit of the National Center for Tumor Diseases Dresden (NCT/UCC) at the University Hospital Carl Gustav Carus in Dresden, Germany
Late-breaking oral abstract presentation
Date & Time: Saturday, November
13, 2021; 12:00 - 12:15 pm EDT
CD8ab TCR-T approach - Preclinical Data Update:
Presentation Title: Improved anti-tumor
activity of next-generation TCR-engineered T cells through CD8 co-expression
Speaker: Mamta Kalra, PhD, Director
CMC (Process Development) at Immatics
Abstract Number: 163
Category: Poster abstract presentation
Date & Time: Friday, November 12, 2021; Poster Hall Hours: 7 am-8:30 pm EDT
All posters presented at the poster hall
will be made available as virtual ePosters throughout the SITC 36th Annual Meeting.
candidates of the IMA200 programs is based on Immatics' proprietary ACTengine approach in which the patient's
own T cells are genetically engineered to express a novel, proprietary TCR directed against a defined cancer target. The modified T cells
are then reinfused into the patient to attack the tumor, an approach also known as TCR-T. ACTengine programs IMA201,
IMA202 and IMA203 are currently in clinical development for the treatment of solid tumor indications, both in the US and in Germany.
IMA204 is currently in pre-clinical development. All ACTengine product candidates can be rapidly manufactured utilizing
a proprietary manufacturing process designed to enhance T cell engraftment and persistence in vivo.
T cell products are manufactured at the Evelyn H. Griffin Stem Cell Therapeutics Research Laboratory in collaboration with UTHealth.
The ACTengine IMA200 Programs are co-funded by the Cancer Prevention and Research Institute of Texas (CPRIT).
the discovery of true targets for cancer immunotherapies with the development of the right T cell receptors with the goal of enabling
a robust and specific T cell response against these targets. This deep know-how is the foundation for our pipeline of Adoptive Cell Therapies
and TCR Bispecifics as well as our partnerships with global leaders in the pharmaceutical industry. We are committed to delivering the
power of T cells and to unlocking new avenues for patients in their fight against cancer.
more information, please contact:
| For Media Inquiries | Investor Relations Contact |
| Jacob Verghese or Stephanie May | Eric Goldstein or John Mullaly |
| Trophic Communications | LifeSci Advisors |
| Phone: +49 89 2388 7731 | Phone: +1 646 791 9729 or +1 617-429-3548 |
| Immatics N.V. | |
| Anja Heuer | Jordan Silverstein |
| Director, Corporate Communications | Head of Strategy |
| Phone: +49 89 540415-606 | Phone: +1 281 810 7545 |
| media@immatics.com | InvestorRelations@immatics.com |