Full Press Release Details
Houston, Texas and Tuebingen, Germany, August 13, 2025–Immatics N.V.(NASDAQ: IMTX, “Immatics” or the “Company”), a clinical-stage biopharmaceutical company and the global leader in precision targeting of PRAME, today provided a business update and reported financial results for the quarter ended June 30, 2025.
“The presentation of positive and extended follow-up Phase 1b data at ASCO has further strengthened our conviction in the transformative therapeutic potential of our PRAME cell therapy, anzu-cel, in patients with advanced cutaneous and uveal melanoma,” said Harpreet Singh, Ph.D., Chief Executive Officer and Co-Founder of Immatics. “The advancement of the SUPRAME Phase 3 trial remains our top priority as we strive to bring anzu-cel to the market for patients with unmet medical need. In addition, Immatics is building the broadest PRAME franchise with the most PRAME indications and modalities. In the coming months, we look forward to delivering updates on our next-generation, half-life extended PRAME bispecific, IMA402, our second-generation PRAME cell therapy, IMA203CD8, as well as data beyond PRAME from IMA401, our bispecific targeting MAGEA4/8.”
Second Quarter 2025 and Subsequent Company Progress
PRAME Franchise
Anzu-cel (IMA203) PRAME Cell Therapy – Market Entry in Advanced MelanomaAnzu-cel (anzutresgene autoleucel), previously called IMA203, is Immatics’ lead PRAME cell therapy and will be the Company’s first PRAME therapy to enter the market in advanced melanoma. The current addressable patient population for anzu-cel’s first target indications, second-line or later (2L) cutaneous melanoma as well as metastatic uveal melanoma, includes ~9,000 patients2.
Phase 3 trial, SUPRAME, for anzu-cel(IMA203)in previously treated, advanced cutaneous melanoma
Phase 1b trial for anzu-cel (IMA203) PRAME cell therapy in patients with metastatic melanoma
Anzu-cel (IMA203) PRAME cell therapy in patients with uveal melanoma
IMA203CD8 PRAME Cell Therapy (GEN2) – Expansion to all Advanced PRAME CancersIMA203CD8 is the Company’s second-generation PRAME cell therapy product candidate being developed with the goal of expanding into all advanced PRAME cancers. Given its enhanced pharmacology profile, once the target dose is reached, the Company intends to pursue the clinical development of this product with a tumor-agnostic approach, starting with gynecologic cancers.
IMA402 PRAME Bispecific – Expansion to Early-Stage PRAME Cancers
To expand the PRAME opportunity to early-stage PRAME cancers, the Company is developing its off-the-shelf, next-generation, half-life extended TCR Bispecific, IMA402. Upon delivering clinical proof-of-concept (“PoC”) in last-line melanoma, Immatics plans to explore its potential in gynecologic cancers, non-small cell lung cancer (NSCLC), breast cancer and other solid tumor indications as well as earlier treatment lines of solid cancers, such as first-line (1L) cutaneous melanoma.
Beyond the PRAME Franchise
IMA401 MAGEA4/8 Bispecific – Driving Innovation Beyond PRAMEImmatics is driving innovation beyond PRAME by evaluating its off-the-shelf, next-generation, half-life extended TCR Bispecific, IMA401, targeting MAGEA4/8 in patients with NSCLC, head & neck cancer, bladder cancer and other solid tumor indications, with the primary goal of developing this product candidate in earlier treatment lines.
Corporate Development
Second Quarter 2025 Financial Results
Cash Position:Cash and cash equivalents as well as other financial assets total $560.5 million1(€478.2 million) as of June 30, 2025, compared to $708.5 million1(€604.5 million) as of December 31, 2024. The decrease is mainly due to ongoing research and development activities and includes unrealized foreign exchange translational losses of $41.7 million1(€35.6 million), which do not impact the expected cash reach.
Revenue:Total revenue, consisting of revenue from collaboration agreements, was $5.5 million1(€4.7 million) for the three months ended June 30, 2025, compared to $22.0 million1(€18.8 million) for the three months ended June 30, 2024.
Research and Development Expenses:R&D expenses were $52.9 million1(€45.1 million) for the three months ended June 30, 2025, compared to $41.3 million1(€35.2 million) for the three months ended June 30, 2024. The increase mainly resulted from costs associated with the advancement of the product candidates in clinical trials.
General and Administrative Expenses:G&A expenses were $15.0 million1(€12.8 million) for the three months ended June 30, 2025, compared to $11.8 million1(€10.1 million) for the three months ended June 30, 2024.
Net Profit and Loss:Net loss was $82.4 million1(€70.3 million) for the three months ended June 30, 2025, compared to a net loss of $21.1 million1(€18.0 million) for the three months ended June 30, 2024. The increase mainly resulted from lower revenue recognized and higher unrealized non-cash foreign exchange rate losses.
Full financial statements can be found in our Report on 6-K filed with the Securities and Exchange Commission (SEC) on August 13, 2025, and published on the SEC website underwww.sec.gov.
Upcoming Investor Conferences
To see the full list of events and presentations, visit:https://investors.immatics.com/events-presentations.
About PRAMEPRAME is a target expressed in more than 50 cancers. Immatics is the global leader in precision targeting of PRAME and has the broadest PRAME franchise with the most PRAME indications and modalities. The Immatics PRAME franchise currently includes three product candidates, two therapeutic modalities and a combination therapy that target PRAME: anzu-cel (anzutresgene autoleucel, IMA203) PRAME cell therapy, IMA203CD8 PRAME cell therapy (GEN2), IMA402 PRAME bispecific and anzu-cel in combination with Moderna’s PRAME adaptive immune modulating therapy.
About ImmaticsImmatics combines the discovery of true targets for cancer immunotherapies with the development of the right T cell receptors with the goal of enabling a robust and specific T cell response against these targets. This deep know-how is the foundation for our pipeline of Adoptive Cell Therapies and TCR Bispecifics as well as our partnerships with global leaders in the pharmaceutical industry. We are committed to delivering the power of T cells and to unlocking new avenues for patients in their fight against cancer.
Immatics intends to use its websitewww.immatics.comas a means of disclosing material non-public information. For regular updates you can also follow us onLinkedInandInstagram.
Forward-Looking StatementsCertain statements in this press release may be considered forward-looking statements. Forward-looking statements generally relate to future events or the Company’s future financial or operating performance. For example, statements concerning timing of data read-outs for product candidates, the timing, outcome and design of clinical trials, the nature of clinical trials (including whether such clinical trials will be registration-enabling), the timing of IND, CTA or BLA filings, estimated market opportunities of product candidates, the Company’s focus on partnerships to advance its strategy, and other metrics are forward-looking statements. In some cases, you can identify forward-looking statements by terminology such as “may”, “should”, “expect”, “plan”, “target”, “intend”, “will”, “estimate”, “anticipate”, “believe”, “predict”, “potential” or “continue”, or the negatives of these terms or variations of them or similar terminology. Such forward-looking statements are subject to risks, uncertainties, and other factors which could cause actual results to differ materially from those expressed or implied by such forward-looking statements. These forward-looking statements are based upon estimates and assumptions that, while considered reasonable by Immatics and its management, are inherently uncertain. New risks and uncertainties may emerge from time to time, and it is not possible to predict all risks and uncertainties. Factors that may cause actual results to differ materially from current expectations include, but are not limited to, various factors beyond management's control including general economic conditions and other risks, uncertainties and factors set forth in the Company’s Annual Report on Form 20-F and other filings with the Securities and Exchange Commission (SEC). Nothing in this press release should be regarded as a representation by any person that the forward-looking statements set forth herein will be achieved or that any of the contemplated results of such forward-looking statements will be achieved. You should not place undue reliance on forward-looking statements, which speak only as of the date they are made. The Company undertakes no duty to update these forward-looking statements. All the scientific and clinical data presented within this press release are – by definition prior to completion of the clinical trial and a clinical study report – preliminary in nature and subject to further quality checks including customary source data verification.
MediaTrophic CommunicationsPhone: +49 151 74416179immatics@trophic.eu
Immatics N.V.Jordan SilversteinHead of StrategyPhone: +1 346 319-3325InvestorRelations@immatics.com
Immatics N.V. and subsidiariesCondensed Consolidated Statement of Loss of Immatics N.V.
| Three months ended June 30, | Six months ended June 30, | ||||||||||||||||
| 2025 | 2024 | 2025 | 2024 | ||||||||||||||
| (Euros in thousands, except per share data) | (Euros in thousands, except per share data) | ||||||||||||||||
| Revenue from collaboration agreements | 4,737 | 18,755 | 23,318 | 49,024 | |||||||||||||
| Research and development expenses | (45,106 | ) | (35,216 | ) | (87,014 | ) | (67,324 | ) | |||||||||
| General and administrative expenses | (12,780 | ) | (10,128 | ) | (24,847 | ) | (21,770 | ) | |||||||||
| Other income | 22 | 25 | 41 | 37 | |||||||||||||
| Operating result | (53,127 | ) | (26,564 | ) | (88,502 | ) | (40,033 | ) | |||||||||
| Change in fair value of liabilities for warrants | 133 | (648 | ) | 1,730 | 395 | ||||||||||||
| Other financial income | 4,421 | 9,665 | 10,685 | 20,580 | |||||||||||||
| Other financial expenses | (22,776 | ) | (305 | ) | (36,113 | ) | (515 | ) | |||||||||
| Financial result | (18,222 | ) | 8,712 | (23,698 | ) | 20,460 | |||||||||||
| Loss before taxes | (71,349 | ) | (17,852 | ) | (112,200 | ) | (19,573 | ) | |||||||||
| Taxes on income | 1,001 | (140 | ) | 1,996 | (660 | ) | |||||||||||
| Net loss | (70,348 | ) | (17,992 | ) | (110,204 | ) | (20,233 | ) | |||||||||
| Net loss per share: | |||||||||||||||||
| Basic | (0.58 | ) | (0.17 | ) | (0.91 | ) | (0.20 | ) | |||||||||
| Diluted | (0.58 | ) | (0.17 | ) | (0.91 | ) | (0.20 | ) |
Immatics N.V. and subsidiariesCondensed Consolidated Statement of Comprehensive Loss of Immatics N.V.
| Three months ended June 30, | Six months ended June 30, | ||||||||||||||||
| 2025 | 2024 | 2025 | 2024 | ||||||||||||||
| (Euros in thousands) | (Euros in thousands) | ||||||||||||||||
| Net loss | (70,348 | ) | (17,992 | ) | (110,204 | ) | (20,233 | ) | |||||||||
| Other comprehensive income/(loss) | |||||||||||||||||
| Items that may be reclassified subsequently to profit or loss | |||||||||||||||||
| Currency translation differences from foreign operations | (5,833 | ) | 462 | (8,544 | ) | 798 | |||||||||||
| Total comprehensive loss for the period | (76,181 | ) | (17,530 | ) | (118,748 | ) | (19,435 | ) |
Immatics N.V. and subsidiariesCondensed Consolidated Statement of Financial Position of Immatics N.V.
| As of | ||||||||
| June 30, 2025 | December 31,2024 | |||||||
| (Euros in thousands) | ||||||||
| Assets | ||||||||
| Current assets | ||||||||
| Cash and cash equivalents | 256,635 | 236,748 | ||||||
| Other financial assets | 221,551 | 367,704 | ||||||
| Accounts receivables | 1,962 | 5,857 | ||||||
| Other current assets | 23,788 | 19,246 | ||||||
| Total current assets | 503,936 | 629,555 | ||||||
| Non-current assets | ||||||||
| Property, plant and equipment | 46,306 | 50,380 | ||||||
| Intangible assets | 1,598 | 1,629 | ||||||
| Right-of-use assets | 14,462 | 13,332 | ||||||
| Other non-current assets | 1,000 | 1,250 | ||||||
| Total non-current assets | 63,366 | 66,591 | ||||||
| Total assets | 567,302 | 696,146 | ||||||
| Liabilities and shareholders’ equity | ||||||||
| Current liabilities | ||||||||
| Provisions | 4,391 | — | ||||||
| Accounts payables | 18,701 | 20,693 | ||||||
| Deferred revenue | 24,389 | 35,908 | ||||||
| Liabilities for warrants | — | 1,730 | ||||||
| Lease liabilities | 3,004 | 2,851 | ||||||
| Other current liabilities | 6,762 | 6,805 | ||||||
| Total current liabilities | 57,247 | 67,987 | ||||||
| Non-current liabilities | ||||||||
| Deferred revenue | 27,561 | 34,161 | ||||||
| Lease liabilities | 14,112 | 13,352 | ||||||
| Deferred tax liability | 3,808 | 5,804 | ||||||
| Total non-current liabilities | 45,481 | 53,317 | ||||||
| Shareholders’ equity | ||||||||
| Share capital | 1,216 | 1,216 | ||||||
| Share premium | 1,170,616 | 1,162,136 | ||||||
| Accumulated deficit | (699,745 | ) | (589,541) | |||||
| Other reserves | (7,513 | ) | 1,031 | |||||
| Total shareholders’ equity | 464,574 | 574,842 | ||||||
| Total liabilities and shareholders’ equity | 567,302 | 696,146 |
Immatics N.V. and subsidiariesCondensed Consolidated Statement of Cash Flows of Immatics N.V.
| Six months ended June 30, | ||||||||
| 2025 | 2024 | |||||||
| (Euros in thousands) | ||||||||
| Cash flows from operating activities | ||||||||
| Net loss | (110,204 | ) | (20,233 | ) | ||||
| Taxes on income | (1,996 | ) | 660 | |||||
| Loss before tax | (112,200 | ) | (19,573 | ) | ||||
| Adjustments for: | ||||||||
| Interest income | (9,719 | ) | (12,660 | ) | ||||
| Depreciation and amortization | 6,166 | 6,116 | ||||||
| Interest expenses | 493 | 420 | ||||||
| Equity-settled share-based payment | 8,471 | 8,605 | ||||||
| Net foreign exchange differences and expected credit losses | 34,241 | (7,723 | ) | |||||
| Change in fair value of liabilities for warrants | (1,730 | ) | (395 | ) | ||||
| Gains from disposal of fixed assets | 40 | 1 | ||||||
| Changes in: | ||||||||
| Decrease in accounts receivables | 3,894 | 1,283 | ||||||
| (Increase)/decrease in other assets | (277 | ) | 766 | |||||
| Decrease in deferred revenue, accounts payables and other liabilities | (15,534 | ) | (48,493 | ) | ||||
| Interest received | 18,012 | 8,260 | ||||||
| Interest paid | (493 | ) | (420 | ) | ||||
| Income tax paid | (5,445 | ) | (2,012 | ) | ||||
| Income tax refunded | 820 | — | ||||||
| Net cash used in operating activities | (73,261 | ) | (65,825 | ) | ||||
| Cash flows from investing activities | ||||||||
| Payments for property, plant and equipment | (4,503 | ) | (11,797 | ) | ||||
| Payments for intangible assets | (190 | ) | (148 | ) | ||||
| Proceeds from disposal of property, plant and equipment | 47 | — | ||||||
| Payments for investments classified in Other financial assets | (280,651 | ) | (356,596 | ) | ||||
| Proceeds from maturity of investments classified in Other financial assets | 396,353 | 196,548 | ||||||
| Net cash provided by/(used in) investing activities | 111,056 | (171,993 | ) | |||||
| Cash flows from financing activities | ||||||||
| Net proceeds from issuance of shares to equity holders | 9 | 174,476 | ||||||
| Payments of lease liabilities | (1,473 | ) | (397 | ) | ||||
| Net cash provided by/(used in) financing activities | (1,464 | ) | 174,079 | |||||
| Net increase/(decrease) in cash and cash equivalents | 36,331 | (63,739 | ) | |||||
| Cash and cash equivalents at the beginning of the period | 236,748 | 218,472 | ||||||
| Effects of exchange rate changes and expected credit losses on cash and cash equivalents | (16,444 | ) | 3,410 | |||||
| Cash and cash equivalents at the end of the period | 256,635 | 158,143 |
Immatics N.V. and subsidiariesCondensed Consolidated Statement of Changes in Shareholders’ Equity of Immatics N.V.
| (Euros in thousands) | Sharecapital | Sharepremium | Accumulateddeficit | Otherreserves | Totalshare-holders’equity | |||||||||||||||
| Balance as of January 1, 2024 | 847 | 823,166 | (604,759 | ) | (1,636 | ) | 217,618 | |||||||||||||
| Other comprehensive income | — | — | — | 798 | 798 | |||||||||||||||
| Net loss | — | — | (20,233 | ) | — | (20,233 | ) | |||||||||||||
| Comprehensive income/(loss) for the period | — | — | (20,233 | ) | 798 | (19,435 | ) | |||||||||||||
| Equity-settled share-based compensation | — | 8,605 | — | — | 8,605 | |||||||||||||||
| Share options exercised | 1 | 1,036 | — | — | 1,037 | |||||||||||||||
| Issue of share capital – net of transaction costs | 183 | 173,257 | — | — | 173,440 | |||||||||||||||
| Balance as of June 30, 2024 | 1,031 | 1,006,064 | (624,992 | ) | (838 | ) | 381,265 | |||||||||||||
| Balance as of January 1, 2025 | 1,216 | 1,162,136 | (589,541 | ) | 1,031 | 574,842 | ||||||||||||||
| Other comprehensive loss | — | — | — | (8,544 | ) | (8,544 | ) | |||||||||||||
| Net loss | — | — | (110,204 | ) | — | (110,204 | ) | |||||||||||||
| Comprehensive loss for the period | — | — | (110,204 | ) | (8,544 | ) | (118,748 | ) | ||||||||||||
| Equity-settled share-based compensation | — | 8,471 | — | — | 8,471 | |||||||||||||||
| Share options exercised | — | 9 | — | — | 9 | |||||||||||||||
| Balance as of June 30, 2025 | 1,216 | 1,170,616 | (699,745 | ) | (7,513 | ) | 464,574 |
1All amounts translated using the exchange rate published by the European Central Bank in effect as of June 30, 2025 (1 EUR = 1.172 USD).2Refers to PRAME+/HLA-A*02:01+ patients in the US and EU5 in 2025; Source: Clarivate Disease Landscape and Forecast