Immatics Announces First Patient Treated with ACTengine IMA203 TCR-T in Combination with Checkpoint Inhibitor Opdivo (nivolumab) in Patients with Advanced Solid Tumors The Phase 1b dose expansion cohort wil

Announces First Patient Treated with ACTengine IMA203 TCR-T in Combination with Checkpoint Inhibitor Opdivo (nivolumab)

in Patients with Advanced Solid Tumors

Texas and Tuebingen, Germany, May XX,

2022 - Immatics N.V. (NASDAQ: IMTX, "Immatics"),

a clinical-stage biopharmaceutical company active in the discovery and development of T cell-redirecting cancer immunotherapies, today

announced that the first patient has been dosed in the IMA203 and nivolumab combination Phase 1b dose expansion cohort. This cohort will

evaluate Immatics' TCR-engineered cell therapy (TCR-T) approach ACTengine IMA203 targeting an HLA-A*02-presented peptide derived

from PRAME, in combination with Bristol Myers Squibb's PD-1 checkpoint inhibitor nivolumab, in patients with advanced solid tumors.

The objectives of the study will be to evaluate the safety, biological activity, and initial anti-tumor activity of the IMA203 and nivolumab

"Initiating the second of three dose expansion cohorts is an important milestone in our comprehensive approach to target PRAME.

It builds on the successful completion of the dose escalation part of the Phase 1 trial and the early positive clinical data we observed

with IMA203," said Cedrik Britten, Chief Medical Officer at Immatics. "We are excited to elucidate how the combination with

an immune checkpoint inhibitor could enhance the potency of our engineered IMA203 T cells. We also look forward to initiating the third

Phase 1b cohort with IMA203CD8, our next generation approach that additionally harnesses the power of CD4 T cells."

The IMA203 and nivolumab

combination Phase 1b dose expansion cohort is expected to enroll up to 18 patients with different types of solid tumors across 10 clinical

trial sites in Germany and the U.S. Bristol Myers Squibb will provide Immatics, the study sponsor of the combination trial, with nivolumab

as part of a clinical supply agreement. Nivolumab has become the standard of care treatment for many solid cancer indications and we

believe it fits well into the IMA203 treatment and observation schedule. According to the clinical trial protocol for ACTengine

IMA203, nivolumab will be administered at regular intervals following IMA203 treatment. The primary endpoint of this cohort is to assess

the safety of the combination. Anti-tumor activity resulting from the drug combination is a secondary endpoint, which will be assessed

through imaging and measured according to the standard Response Evaluation Criteria In Solid Tumors (RECIST).

treatment of IMA203 and nivolumab is part of Immatics' strategy to realize the full clinical potential of IMA203 TCR-T targeting PRAME.

Based on this strategy, the company has expanded the IMA203 trial to a total of three Phase 1b dose expansion cohorts - each designed

to assess observed objective response rates, demonstrate durability of response, and form the basis for enrollment in pivotal studies.

In addition to the IMA203 and nivolumab combination (first patient treated, initial data read-out planned for YE 2022), Immatics will

also investigate IMA203 as monotherapy (patient enrollment ongoing, next data read-out planned in 2H 2022) and IMA203CD8, a next-generation

cell therapy where IMA203-engineered T cells are co-transduced with a CD8 co-receptor (initiation planned for 2Q 2022, initial

data read-out planned for YE 2022).

(nivolumab) is a trademark of Bristol-Myers Squibb Company

T cells are directed against an HLA-A*02-presented peptide derived from preferentially expressed antigen in melanoma (PRAME), a protein

frequently expressed in a large variety of solid cancers thereby supporting the programs' potential to address a broad cancer patient

population. Immatics' PRAME peptide is present at a high copy number per tumor cell and is homogenously and specifically expressed

in tumor tissue. The peptide has been identified and characterized by Immatics' proprietary mass spectrometry-based target discovery

platform XPRESIDENT . Through its proprietary TCR discovery and engineering platform XCEPTOR , Immatics has generated a highly

specific T cell receptor (TCR) against this target for its TCR-based cell therapy approach, ACTengine IMA203.

a personalized approach for patients with advanced solid tumors. The patient's own T cells are genetically engineered to express

a novel, proprietary TCR directed against a defined cancer target. The modified T cells are then reinfused into the patient to attack

the tumor. The approach is also known as TCR-engineered cell therapy (TCR-T). All Immatics' ACTengine product candidates can

be rapidly manufactured utilizing a proprietary manufacturing process designed to enhance T cell engraftment and persistence in vivo.

T cell products are manufactured at the Evelyn H. Griffin Stem Cell Therapeutics Research Laboratory in collaboration with UTHealth.

The ACTengine Programs are co-funded by the Cancer Prevention and Research Institute of Texas (CPRIT).

the discovery of true targets for cancer immunotherapies with the development of the right T cell receptors with the goal of enabling

a robust and specific T cell response against these targets. This deep know-how is the foundation for our pipeline of Adoptive Cell Therapies

and TCR Bispecifics as well as our partnerships with global leaders in the pharmaceutical industry. We are committed to delivering the

power of T cells and to unlocking new avenues for patients in their fight against cancer.

Twitter and LinkedIn.

statements in this press release may be considered forward-looking statements. Forward-looking statements generally relate to future

events or Immatics' future financial or operating performance. For example, statements concerning the timing of product candidates

and Immatics' focus on partnerships to advance its strategy are forward-looking statements. In some cases, you can identify forward-looking

statements by terminology such as "may", "should", "expect", "intend", "will",

"estimate", "anticipate", "believe", "predict", "potential" or "continue",

or the negatives of these terms or variations of them or similar terminology. Such forward-looking statements are subject to risks, uncertainties,

and other factors which could cause actual results to differ materially from those expressed or implied by such forward looking statements.

These forward-looking statements are based upon estimates and assumptions that, while considered reasonable by Immatics and its management,

are inherently uncertain. New risks and uncertainties may emerge from time to time, and it is not possible to predict all risks and uncertainties.

Factors that may cause actual results to differ materially from current expectations include, but are not limited to, various factors

beyond management's control including general economic conditions and other risks, uncertainties and factors set forth in filings with

the SEC. Nothing in this presentation should be regarded as a representation by any person that the forward-looking statements set forth

herein will be achieved or that any of the contemplated results of such forward-looking statements will be achieved. You should not place

undue reliance on forward-looking statements, which speak only as of the date they are made. Immatics undertakes no duty to update these

forward-looking statements. All the scientific and clinical data presented within this press release are - by definition prior

to completion of the clinical trial and a clinical study report - preliminary in nature and subject to further quality checks including

customary source data verification.

more information, please contact: