Full Press Release Details
IMM124E - Demonstrates Antiviral T-Cell
Melbourne, Australia, October 08, 2021: Immuron
Limited (ASX: IMC; NASDAQ: IMRN), an Australian biopharmaceutical company focused on developing and commercializing oral immunotherapeutic
products for the prevention and treatment of gut pathogens, is pleased to notify shareholders of a recent publication describing the potential
antiviral benefits of IMM-124E in a mouse model and human clinical study. IMM124E, the Company's proprietary product, is used to
manufacture Immuron's flagship commercially available and over-the-counter gastrointestinal and digestive health immune supplements
Travelan and Protectyn . The studies were conducted independently by the Hadassah Medical Center, Jerusalem Israel.
The research findings were recently published
on the 1st of October 2021 in the Journal Drug Development Research entitled Augmented antiviral T cell immunity by oral administration
of IMM-124E in preclinical models and a phase I/IIa clinical trial: A method for the prevention and treatment of COVID-19 (https://doi.org/10.1002/ddr.21890).The
paper examines the ability of IMM-124E to promote antiviral interferon- (IFN ) T cell responses in a preclinical mouse model
and in a phase I/IIa clinical study conducted in 5 human health volunteers. The aim of the research study was to determine the ability
of IMM-124E to promote antiviral interferon (IFN ) T cell responses. In the preclinical study, mice were orally administered
with HBC for 5 days and tested for the number of T cell clones secreting IFN in response to viral antigens of the swine flu, New
Caledonia influenza, and cytomegalovirus. The reported data suggests that that IMM124E enhance antiviral immunity across the viral strains
tested. A similar response was observed in the human study. Healthy volunteers were recruited and received IMM-124E at a daily dose of
600 mg for four consecutive days and 1200 mg for an additional day. Blood samples were collected before and after IMM-124E treatment
and tested for the number of T cell clones secreting IFN in response to viral antigens of SARS-CoV-2 and Hepatitis B virus. The
preliminary clinical data reported suggested a similar effect was observed in humans in augmenting antiviral responses against COVID-19
and Hepatitis B. While more thorough and detailed investigations are required to further validate the results, this is very encouraging
has been pursuing the antiviral activities of IMM-124E and these recent published results lend support to the ongoing R&D program.
Immuron has previously reported research investigations on IMM-124E which demonstrated neutralizing activity against the severe
acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the virus that causes COVID-19 (ASX announcements dated 13 May 2021, 15 December
2020 and 21 July 2020).
The company is also pleased to report that it
has filed a Patent Cooperation Treaty (PCT) application to seek patent protection internationally for IMM-124E which demonstrated neutralizing
activity against the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the virus that causes COVID-19.
This release has been authorised by the directors
Immuron Limited (ASX:
IMC, NASDAQ: IMRN), is an Australian biopharmaceutical company focused on developing and commercializing orally delivered targeted polyclonal
antibodies for the treatment of inflammatory mediated and infectious diseases. Immuron has a novel and safe technology platform with one
commercial asset generating revenue. In Australia, Travelan is a listed medicine on the Australian Register of Therapeutic Goods
(AUST L 106709) and is indicated to reduce the risk of Travellers' Diarrhea, reduce the risk of minor gastro-intestinal disorders
and is antimicrobial. In Canada, Travelan is a licenced natural health product (NPN 80046016) and is indicated to reduce the risk
of Travellers' Diarrhea. In the U.S., Travelan is sold as a dietary supplement for digestive tract protection in accordance
with section 403 (r)(6) of the Federal Drug Administration (FDA).
orally administered passive immunotherapy that prophylactically reduces the likelihood of contracting travelers' diarrhea, a
digestive tract disorder that is commonly caused by pathogenic bacteria and the toxins they produce. Travelan is a highly
purified tabletized preparation of hyper immune bovine antibodies and other factors, which when taken with meals bind to diarrhea-causing
bacteria and prevent colonization and the pathology associated with travelers' diarrhea. In Australia, Travelan is a listed
medicine on the Australian Register for Therapeutic Goods (AUST L 106709) and is indicated to reduce the risk of Travelers' Diarrhea,
reduce the risk of minor gastro-intestinal disorders and is antimicrobial. In Canada, Travelan is a licensed natural health product
(NPN 80046016) and is indicated to reduce the risk of Travelers' Diarrhea. In the U.S., Travelan is sold as a dietary supplement
for digestive tract protection.
About Travelers' diarrhea
is a gastrointestinal infection with symptoms that include loose, watery (and occasionally bloody) stools, abdominal cramping, bloating,
and fever, Enteropathogenic bacteria are responsible for most cases, with enterotoxigenic Escherichia coli (ETEC) playing a dominant
causative role. Campylobacter spp. are also responsible for a significant proportion of cases. The more serious infections with Salmonella
spp. the bacillary dysentery organisms belonging to Shigella spp. and Vibrio spp. (the causative agent of cholera) are often confused
with travelers' diarrhea as they may be contracted while travelling and initial symptoms are often indistinguishable.
For more information
visit: http://www.immuron.com
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