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Appendix 4E - Preliminary Final Report For the Financial Year Ended 30 June 2017 Current Reporting Period - Year Ended 30 June 2017 Previous Reporting Period - Year Ended 30 June 2016 In compliance with Listing Rule 4.2A

Key Takeaway: Appendix 4E - Preliminary Final Report For the Financial Year Ended 30 June 2017 Current Reporting Period - Year Previous Reporting Period - Year Ended 30 June 2016 In compliance with Listing Rule 4.2A. 30 June 2017 30 June 2016 Revenues Up 39% to 1,396,197 from 1,001,07

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Appendix 4E - Preliminary Final Report
For the Financial Year Ended 30 June 2017
Current Reporting Period - Year
Previous Reporting Period - Year Ended 30 June 2016
In compliance with Listing Rule 4.2A.
30 June 2017 30 June 2016
Revenues Up 39% to 1,396,197 from 1,001,077
Loss after tax attributable to members UP 22% to (6,804,154) from (5,599,004)
Net loss for the period attributable to members UP 22% to (6,804,154) from (5,599,004)
Net Tangible Asset per Security (cents per security)
As at 30 June 2017 5.056
As at 30 June 2016 6.168
Dividends (distribution) Amount per Security Franked Amount per Security
Current period n/a n/a
Previous corresponding period n/a n/a
Record date for determining entitlements to dividend n/a
Details of dividend reinvestment plans in operation None
Details of entities over which control has been gained or lost during the period None
Details of Associates and Joint Ventures None
These accounts have been subject to review and there has been no qualification or dispute.
Explanation of the above information:
Refer to the Directors' Report.
Approved Date: Thursday, 31 st August 2017
Preliminary Financial Report
For the Year Ended 30 June 2017
In compliance with Listing Rule 4.2A
Directors' Report 4
Consolidated Statement of Profit or Loss and Other Comprehensive Income 8
Consolidated Statement of Financial Position 9
Consolidated Statement of Changes in Equity 10
Consolidated Statement of Cash Flows 11
Notes to the Financial Statements 12
Company Directory 21
Your Directors present their report on Immuron Limited for the
year ended 30 June 2017.
The following persons were directors of Immuron Limited and
its entity it controls during the year and up to the date of this report, unless otherwise stated:
Dr. Roger Aston Non-Executive Chairman
Mr. Peter Anastasiou Deputy Executive Vice Chairman
Mr. Stephen Anastasiou Non-Executive Director
Mr. Daniel Pollock Non-Executive Director
Prof. Ravi Savarirayan Independent Non-Executive Director (Appointed 7 April 2017)
REVIEW OF OPERATIONS
Fatty Liver Portfolio
Three Ongoing Phase II Programs in Clinical Development (NASH,
ASH and Pediatric NAFLD)
The lead Principle Investigator for the
Immuron non-alcoholic steatohepatitis (NASH) clinical study Dr Arun Sanyal, is the former President of AASLD (American Association
for the Study of Liver Diseases) and current Chair of the Liver Study Section at the National Institute of Health (NIH).
The study achieved its recruitment goal
of at least 120 patients this year and successfully enrolled 133 patients with biopsy proven NASH. The primary endpoint is changes
in liver fat content confirmed by MRI and secondary endpoints being changes in ALT (liver enzymes). The top-line results for the
study are expected to be reported by Q4 2017.
NASH is a severe form of non-alcoholic
fatty liver disease (NAFLD). It affects about 16 million people annually in the United States alone, making it a prime opportunity
for the pharmaceutical and biotechnology industries.
With 17.3 percent of Americans aged 15
- 19 suffering NAFLD, Immuron's Phase I/II clinical trial with Emory University is timely. Health authorities estimate
paediatric NAFLD affects five to 10 percent of the US paediatric population, with no current approved treatments.
The lead Principle Investigator for our
Pediatric NAFLD study is Dr Miriam Vos, Emory University. Dr Vos specializes in the treatment of gastrointestinal disease in children
as well as fatty liver disease and obesity.
Our NIH funded Phase II double blind, placebo
control, randomized clinical study of IMM-124E enrolled the first patient into the study in February this year and has so far randomized
over 10% of the targeted 40 patients into the study. The primary endpoint is changes in ALT (liver enzymes) following 3 months
of treatment with top-line results expected in Q4 2018.
Dr Arun Sanyal is also the lead Principle
Investigator of the Immuron alcoholic steatohepatitis (ASH) clinical study which is also funded by the NIH. Over 50% of the targeted
66 patients have been randomized into the study. The primary endpoint is changes in ALT (liver enzymes) with top-line results are
expected in Q1 2019.
US Securities and Exchange Commission
Immuron successfully completed its Initial
Public Offering (IPO) on 9 June 2017. The Company, through its lead broker Joseph Gunnar & Co. LLC and Rodman & Rendshaw
placed 610,000 ADSs and 701,500 Warrants raising USD$6.1M before costs. The close of this raising marked a significant milestone
in Immuron's lifecycle as the Company not only secured additional funding to process its clinical portfolio and current primary
clinical trial to completion, but it also gained international exposure to the much large US market.
The listing process had been an ongoing
process of audit, legal and regulatory reviews for a number of months to ensure Immuron's compliance with SEC and NASDAQ
NASH Clinical Trial Achieves Major Milestones
and Receive New US Stimulus
The Company reported the results of the
planned interim analysis in July this year. The primary objective of the interim analysis was to evaluate the safety of IMM-124E.
The interim analysis was conducted by an Independent Committee to maintain blindness of both company and investigators as required
to maintain the study integrity.
The Committee also explored the data for
signals of efficacy from the primary, secondary and exploratory end points. The analysis was not powered for efficacy due to the
limited sample size.
The report submitted to the Company by
the Committee confirmed that there were no safety concerns or adverse events, serum biochemistry, hematology, vital signs, or physical
examination findings for both treatment groups. We were very pleased to be able to report the efficacy signals on liver enzymes
(ALT and AST) which demonstrated a dose related reduction in both treatment doses at 24 weeks, though not statistically different
As these parameters inherently fluctuate
over time and are significantly affected by baseline values the interim analysis committee also had scheduled to perform additional
analyses on the data set to correct for these inherent variations. Comparing the Area Under Curve for the ALT/AST data over time
of IMM-124E to Placebo, accounts for all the available data.
Such analysis demonstrated a significant
reduction of ALT and AST over time (AUC ANCOVA analysis) compared to placebo. A dose-related effect was reported when the greatest
decrease occurred in the highest dose group, with the low dose group decreasing by an intermediate amount compared with the placebo
The Company believes that this documented
effect, together with a correlation between ALT and AST, is the proof of concept for a biological effect demonstrating decrease
Immuron has also advanced its world-leading
IMM-124E research in NASH with two new studies at Duke University and Sanyal Biotechnology. The studies should augment the evidence
of IMM-124E's unique mechanism of action (MOA) and expected effect on NASH. The results from these studies will supplement
our pre-clinical and clinical studies to date, including the anti-fibrotic effect seen in the CCl4 model and the metabolic and
immunological improvements seen in both the Ob-Ob mice as well as the Company's phase I clinical study.
The studies will attempt to generate comparable
results in the two leading NASH mouse models which mimic the full clinical spectrum of human NASH, from simple steatosis to substantial
fibrosis and cirrhosis. The additional preclinical studies will proceed under the leadership of two internationally renowned NASH
researchers, Dr Arun Sanyal, founder of Sanyal Biotechnology, and Dr Anna-Mae Diehl, Director at the Duke University Liver Centre.
The studies are ongoing and are expected
to be completed by Q4 2017.
Clostridium Difficile Infection
(CDI) Trial Drug Completes Manufacturing Phase
Immuron is pursuing the biopharmaceutical
research and development for an effective and safe non-antibiotic treatment of CDI which accounts for more than 450,000 patients
and over 29,000 deaths per year in the United States alone. The IMM-529 drug product for the study has been manufactured and is
a first-in class oral immunotherapeutic targeting the treatment of Clostridium difficile infection. IMM-529 has been shown in preclinical
tests to be an effective treatment in all phases of the disease and success in this trial will provide encouragement to the Board
and Management that the IMM-529 drug product has significant potential for continued clinical development.
The Company received approval from the
Israeli Ministry of Health (MoH) and the Hadassah Medical Center Ethics Committee in August of this year to perform Immuron's
IMM-529 clinical study. Immuron has completed the site initiation and the site is open for enrolment. The first of 60 patients
is scheduled to be randomized by end of September 2017. The Phase I/II randomized, double-blind, placebo-control clinical study
is designed to evaluate the safety and preliminary efficacy of Immuron's IMM-529 drug product for the treatment of CDI.
Eligible patients will be randomized, in
Last updated: Aug 31, 2017