Harnessing the Human Memory B Cell Response To Develop Antibody - Based Therapeutics

25 Novel Insights from Discovery Engine 1. Adv Clin Chem. 2016;74:103 - 41.DOI: 10.1016/bs.acc.2015.12.005 2. Mol Cancer. 2019 Oct 23;18(1):146. doi : 10.1186/s12943 - 019 - 1074 - 3 3. Including some commercially - validated targets such as ERBB2 Provides Critical Insights Into Cancer Biology Such As: Membrane dynamics Exosome control of the tumor microenvironment 1 - 2 Novel immune checkpoints that serve as functional, tumor - derived inhibitors of immunity CONFIDENTIAL - FOR INTERNAL USE ONLY Systematic Mining of Antibodies Reveal Disease Relevant Functional Clusters 300,000 HYBRIDOMAS 1,300 HITS >50 ANTIBODY / ANTIGEN PAIRS 3 A Highly Productive Platform Immune Modulation Novel Targets Discovery Engine Extracellular Matrix

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