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Immutep Announces Data from EFTISARC-NEO Phase II Evaluating Neoadjuvant Efti in Soft Tissue Sarcoma Accepted for Oral Presentation at CTOS 2025

Key Takeaway: Immutep Limited announced that its EFTISARC-NEO Phase II trial has been accepted for oral presentation at the CTOS 2025 Annual Meeting. This trial is the first to assess eftilagimod alpha in combination with radiotherapy and KEYTRUDA for soft tissue sarcoma patients. The study highlights the urgent need for effective treatments in this orphan disease.
Price reaction · baseline $1.65 (2025-09-05 close) · hit pre-market · clean, no other IMMP news in the window
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POSITIVE FACTORS

  • EFTISARC-NEO trial accepted for oral presentation at CTOS 2025.
  • First study evaluating eftilagimod alpha in neoadjuvant setting.
  • Addresses high unmet medical need in soft tissue sarcoma.

BiopharmaWatch Analysis

From our catalyst data and publicly available data · not financial advice
Best trade, last catalyst
+76%
120-day peak, hindsight
Typical move
5.4%
average across 13 past catalysts
Lead asset
eftilagimod alfa
Phase 3 · Advanced/Metastatic Non-Small Cell Lung Cancer (NSCLC)

Full Press Release Details

SYDNEY, AUSTRALIA, Sept. 08, 2025 (GLOBE NEWSWIRE) --Immutep Limited(ASX: IMM; NASDAQ: IMMP) (“Immutep” or “the Company”), a late-stage immunotherapy company targeting cancer and autoimmune diseases, today announces an abstract for the EFTISARC-NEO Phase II investigator-initiated trial has been accepted for oral presentation at the Connective Tissue Oncology Society (CTOS) 2025 Annual Meeting taking place 12-15 November 2025, in Boca Raton, Florida.
EFTISARC-NEO is the first study to evaluate eftilagimod alpha (efti) in a neoadjuvant setting (prior to surgery) administered in combination with radiotherapy plus KEYTRUDA®(pembrolizumab) for patients with soft tissue sarcoma (STS).
Presentation Details
Title: Primary endpoint and translational correlates from EFTISARC-NEO: phase II trial of neoadjuvant eftilagimod alpha (efti), pembrolizumab, and radiotherapy in patients with resectable soft tissue sarcoma
Session: Immunotherapy & Cell Therapy in Sarcoma: Emerging Frontiers
Presenter: Pawel Sobczuk, M.D., Ph.D., Department of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie National Research Institute of Oncology
Date: Thursday, 13 November 2025, 1:30 PM – 3:00 PM ET
Format: Oral Presentation
STS is an orphan disease with high unmet medical need and a poor prognosis for patients. The incidence of STS varies in different regions globally. In the United States, the number of new STS cases in 2025 is estimated to be ~13,520 with ~5,420 deaths, according to the American Cancer Society.1
EFTISARC-NEO is is being conducted by the Maria Skłodowska-Curie National Research Institute of Oncology in Warsaw, Poland. The study is primarily funded with an approved grant from the Polish government awarded by the Polish Medical Research Agency program. For more information on the trial visit clinicaltrials.gov (NCT06128863).
The presentation slides will be available on the Posters & Publications section of Immutep’s website after the presentation at CTOS 2025.

About Immutep

Immutep is a late-stage biotechnology company developing novel immunotherapies for cancer and autoimmune disease.The Company is a pioneer in the understanding and advancement of therapeutics related to Lymphocyte Activation Gene-3 (LAG-3), and its diversified product portfolio harnesses LAG-3’s ability to stimulate or suppress the immune response. Immutep is dedicated to leveraging its expertise to bring innovative treatment options to patients in need and to maximise value for shareholders. For more information, please visitwww.immutep.com.
KEYTRUDA® is a registered trademark of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA.

Australian Investors/Media:Eleanor Pearson, Sodali & Co.+61 2 9066 4071;eleanor.pearson@sodali.com

U.S. Investors/Media:Chris Basta, VP, Investor Relations and Corporate Communications+1 (631) 318 4000;chris.basta@immutep.com

Frequently Asked Questions

What is the EFTISARC-NEO trial?

The EFTISARC-NEO trial is a Phase II study evaluating eftilagimod alpha in combination with radiotherapy and KEYTRUDA for soft tissue sarcoma.

When will the trial data be presented?

The trial data will be presented at the CTOS 2025 Annual Meeting from November 12-15, 2025.

Where is the EFTISARC-NEO trial being conducted?

The trial is being conducted by the Maria Skłodowska-Curie National Research Institute of Oncology in Warsaw, Poland.

What is the significance of this trial?

This trial addresses a high unmet medical need in soft tissue sarcoma, which has a poor prognosis.

Last updated: Sep 8, 2025