Full Press Release Details
SYDNEY, AUSTRALIA October 28, 2019
Immutep Limited (ASX: IMM; NASDAQ: IMMP) ( Immutep or the Company ), a biotechnology company developing novel immunotherapy treatments for cancer and autoimmune diseases, provides an update on the ongoing
development of its product candidates.
Eftilagimod alpha ( efti or IMP321 ) Clinical Update
AIPAC - Phase IIb clinical trial
The Company is fully on
track to report progression-free survival data and overall response rate data in Q1 of calendar year 2020. AIPAC is potentially a pivotal clinical trial, meaning it could serve as the basis to pursue appropriate regulatory approval pathways for
efti, subject to sufficient and clinically meaningful data from the trial and regulatory interactions. Importantly AIPAC would be the first successful randomised trial in solid tumors for an antigen presenting cell activator and would be a very
significant step in validating this new class of products.
TACTI-002 - Phase II clinical trial
Immutep presented initial encouraging data of the first cohort of 17 patients for Part A (patients with first line
non-small cell lung cancer) of its TACTI-002 Phase II study, which is being conducted in collaboration with Merck & Co., Inc., Kenilworth, NJ, USA (known as
MSD outside the United States and Canada), in June. Part A has been expanded by the data monitoring committee in September to include 19 additional patients.
Recruitment is ongoing for Part B (second line non-small cell lung cancer) and Part C (second line head and neck
squamous cell carcinoma), where 6 and 12 patients have been recruited, respectively. There is also potential to expand Parts B and C, subject to the required number of predefined patient responses being observed in these groups. Hence, in total 35
patients have been recruited across all three groups in TACTI-002.
Immutep will report data updates from the open label TACTI-002 study at SITC on 8 November, at 7.00am EST, as well as in Q1 2020.
TACTI-mel - Phase I clinical trial
Immutep s CSO and CMO presented final efficacy data at the World Immunotherapy Congress in Basel on 15 October 2019. The key findings were
efti has a favourable safety profile in combination with pembrolizumab with no dose-limiting toxicities and the recommended dosage level for a Phase II trial is 30 mg of efti (this is the dosage level currently being evaluated in the ongoing TACTI-002 Phase II trial).
In addition, final efficacy data has been reported, confirming deep durable responses have
been observed, with 12 patients (50%) having a decrease of 75% in the target lesions and 9 patients (38%) being treated for 12 months with pembrolizumab
Final safety data is expected to be presented in H1 2020.
INSIGHT-004 - Phase I clinical trial
In June 2019, the first patient was enrolled in Germany and has received the first dose of treatment in INSIGHT-004,
the fourth arm of the INSIGHT trial (INSIGHT-004 is also known as Stratum D of INSIGHT) which is being conducted in collaboration with Merck KGaA, Darmstadt, Germany and Pfizer Inc. The first cohort (6 mg of
efti) is now fully recruited with six patients in total. The second cohort (30 mg of efti) will recruit six patients, bringing the total participants in the study to 12 patients.
Initial safety data from the study is expected to be reported in Q4 2019.
The company is also working on
upscaling the manufacturing process from 200L to 2,000L single-use bioreactors at the WuXi Biologics manufacturing plant (Wuxi, China) in order to be better prepared for potential commercial manufacturing and
additional registration trials in multiple indications.
Immutep is continuing cell line development and
the associated manufacturing steps of its IMP761 product candidate following encouraging preclinical results that demonstrated the immunosuppressive activity of IMP761.
Update on Programs Fully Funded by Immutep s Licensing Partners
GlaxoSmithKline (GSK) Phase I and II clinical trials
In September, Immutep announced that it will receive a milestone payment from GSK of 4 million (~A$7.39 million) related to the first patient being
dosed in GSK s Phase II clinical trial evaluating GSK2831781 in ulcerative colitis. This milestone payment was received by Immutep from GSK in October.
Novartis Phase I and II clinical trials
Immutep s partner Novartis, is conducting five trials of LAG525, derived from IMP701, which is licensed from Immutep. Earlier this year, it
commenced the recruitment of 220 patients for its combinatory Phase Ib clinical trial in triple negative breast cancer.
Recruitment is also ongoing for
its Phase II study in advanced triple negative breast cancer and its Phase II study in melanoma. A further two trials are active, namely a Phase I/II trial in advanced solid tumors and a Phase II trial in a range of advanced malignancies.
Eddingpharm (EOC Pharma) Phase I clinical trial
The Phase I clinical study is ongoing with efti for the treatment of metastatic breast cancer.
Immutep is a globally active biotechnology
company that is a leader in the development of immunotherapeutic products for the treatment of cancer and autoimmune disease. Immutep is dedicated to leveraging its technology and expertise to bring innovative treatment options to market for
patients and to maximize value to shareholders. Immutep is listed on the Australian Securities Exchange (IMM), and on the NASDAQ (IMMP) in the United States.
Immutep s current lead product candidate is eftilagimod alpha ( efti or IMP321 ), a soluble
LAG-3Ig fusion protein based on the LAG-3 immune control mechanism. This mechanism plays a vital role in the regulation of the T cell immune response. Efti is currently
in a Phase IIb clinical trial as a chemoimmunotherapy for metastatic breast cancer termed AIPAC; a Phase II clinical trial being conducted in collaboration with Merck & Co., Inc., Kenilworth, NJ, USA (known as MSD outside the
United States and Canada) referred to as TACTI-002 (Two ACTive Immunotherapies) to evaluate a combination of efti with KEYTRUDA (pembrolizumab) in
several different solid tumours (clinicaltrials.gov identifier NCT03625323); a Phase I clinical trial being conducted in collaboration with Merck KGaA, Darmstadt, Germany and Pfizer Inc. referred to as
INSIGHT-004 to evaluate a combination of efti with avelumab (clinical trials.gov identifier NCT03252938); and a Phase I combination therapy trial in metastatic melanoma termed TACTI-mel (clinicaltrials.gov
identifier NCT02676869).
Further information can be found on the Company s website www.immutep.com or by contacting:
Australian Investors/Media:
Matthew Gregorowski,
+61 2 8234 0105; mgregorowski@citadelmagnus.com
U.S. Investors/Media:
Garth Russell, LifeSci Advisors
+1 (646) 876-3613; garth@lifesciadvisors.com