Full Press Release Details
Immutep Signs Exclusive License Agreement with Cardiff University
for Next Generation Anti-LAG-3 Molecules for Cancer
SYDNEY, AUSTRALIA 25 June 2024 Immutep Limited (ASX: IMM; NASDAQ: IMMP) ( Immutep or
the Company ), a clinical-stage biotechnology company developing novel LAG-3 immunotherapies for cancer and autoimmune diseases, today announces a License Agreement with Cardiff University granting
the Company exclusive rights to develop and commercialise anti-LAG-3 small molecules.
A number of promising compounds that block LAG-3, an immune checkpoint known to reduce the immune system s
response to fight cancer, have been identified under Immutep s collaboration with the world-leading scientists at Cardiff University. Led by Professor Andrew Godkin of Cardiff University, Professor Andrea Brancale (now of the University of
Chemistry and Technology, Prague), and Dr Fr d ric Triebel, Immutep CSO, the compounds were identified by chemical library screening, molecular modelling (virtual screening) and synthetic chemistry.
Professor Andrew Godkin of Cardiff University said: Our collaboration with Immutep has been exciting and fruitful, resulting in a number of small
molecules with the potential to fight cancer by blocking the interaction between LAG-3 on T cells and MHC Class II on antigen-presenting cells. Small molecules represent the next generation of anti-LAG-3 therapies and hold tremendous promise, as they can be given to cancer patients as a convenient oral pill.
To date, over a dozen companies have initiated clinical trials investigating antagonist or blocking LAG-3
antibodies including Bristol Myers Squibb s relatlimab, which was approved by the FDA in 2022 as part of a fixed dose combination with nivolumab for the treatment of metastatic melanoma. This new combination, known as Opdualag , achieved commercial sales of US$252 million and US$627 million in 2022 and 2023, respectively. Immutep s program aims to develop an orally-available small molecule anti-LAG-3 treatment for cancer patients at a lower cost compared with the anti-LAG-3
monoclonal and bi-specific antibodies that are commercially available or under clinical development today.
Dr. Fr d ric Triebel, Immutep CSO, said: With our first-in-class MHC Class II agonist, eftilagimod alfa, entering late-stage clinical trials in oncology and IMP761, the world s first LAG-3 agonist antibody
targeting the root cause of autoimmune diseases scheduled to enter the clinic by mid-year, the team at Immutep continues to build on its pioneering leadership position in the
LAG-3 therapeutic landscape with this novel program. This License Agreement harnesses many years of collaborative work with the expert team at Cardiff University and enables us to advance the most promising
preclinical compounds towards the next stage of development.
A joint patent application has been filed by Immutep S.A.S. and University College
Cardiff Consultants Limited (a Cardiff University affiliate) to protect the new intellectual property. The License Agreement builds on Immutep s collaboration with Cardiff University which commenced in 2019. University College Cardiff
Consultants Limited will receive an upfront payment of 25,000 and a milestone payment upon first commercial sale of a licensed product, and is eligible to receive low single-digit sales based royalties.
About Cardiff University
Cardiff University is recognised in independent government assessments as one of Britain s leading teaching and research universities and is a member of
the Russell Group of the UK s most research intensive universities. The 2021 Research Excellence Framework found 90% of the University s research to be word-leading or internationally excellent. Among its academic staff are two Nobel
Laureates, including the winner of the 2007 Nobel Prize for Medicine, Professor Sir Martin Evans. Founded by Royal Charter in 1883, today the University combines impressive modern facilities and a dynamic approach to teaching and research. The
University s breadth of expertise encompasses: the College of Arts, Humanities and Social Sciences; the College of Biomedical and Life Sciences; and the College of Physical Sciences and Engineering. Its University institutes bring together
academics from a range of disciplines to tackle some of the challenges facing society, the economy, and the environment. More at www.cardiff.ac.uk.
Immutep is a clinical-stage biotechnology
company developing novel LAG-3 immunotherapy for cancer and autoimmune disease. We are pioneers in the understanding and advancement of therapeutics related to Lymphocyte Activation Gene-3 (LAG-3), and our diversified product portfolio harnesses its unique ability to stimulate or suppress the immune response. Immutep is dedicated to leveraging its
expertise to bring innovative treatment options to market for patients in need and to maximise value for shareholders. For more information, please visit www.immutep.com.
Australian Investors/Media:
Catherine Strong, Morrow
+61 (0)406 759 268; c.strong@morrowsodali.com
U.S. Investors/Media:
Chris Basta, VP, Investor
Relations and Corporate Communications
+1 (631) 318 4000; chris.basta@immutep.com
This announcement was authorised for release by the Board of Immutep Limited.
Immutep Limited, Level 32, Australia Square, 264 George Street, Sydney NSW 2000, Australia