Full Press Release Details
Immutep Receives Positive Feedback from FDA on Late-Stage Clinical Development
of Eftilagimod Alpha in Non-Small Cell Lung Cancer
SYDNEY, AUSTRALIA 16 May 2023 Immutep Limited (ASX: IMM; NASDAQ: IMMP) ( Immutep or the
Company ), a clinical-stage biotechnology company developing novel LAG-3 immunotherapies for cancer and autoimmune disease, today announces it has received positive feedback from the US Food and Drug
Administration (FDA), regarding the Company s late-stage clinical development plans for its first-in-class soluble LAG-3
protein and MHC Class II agonist, eftilagimod alpha ( efti ), for the treatment of 1st line non-small cell lung cancer (NSCLC).
The FDA is supportive of a registrational trial to evaluate efti in combination with an
anti-PD-1 therapy based on the encouraging data from the Phase II TACTI-002, Part A (N=114) in 1st line NSCLC patients, no matter
their level of PD-L1 expression, presented in a late-breaking oral abstract presentation at the 37th Annual Society of Immunotherapy of Cancer (SITC) Meeting in November 2022.
Among the items discussed at the meeting were the toxicological package and general aspects of the trial design, including statistics and potential patient
population with a focus on 1st line NSCLC patients with a Tumor Proportion Score (TPS) PD-L1 of >1% for which efti plus pembrolizumab has already received Fast Track designation. This trial
will be named TACTI-004 (Two ACTive Immunotherapies).
Immutep CEO, Marc Voigt, commented:
In light of our compelling clinical data that efti has generated in combination with anti-PD-1 therapy, this meeting with the FDA is a critical step in our
late-stage development process for 1st line non-small cell lung cancer. We are thankful for the positive feedback as we continue moving forward with our unique immuno-oncology approach for the many cancer
patients impacted by this difficult disease.
Immutep CSO, Dr. Fr d ric Triebel, stated: We are very
pleased with our constructive dialogue with the FDA establishing a clear path forward for efti in front line non-small cell lung cancer. These interactions represent an important milestone within
Immutep s three main clinical programs targeting cancers that affect large patient populations, positioning efti to make a significant impact for the many patients in need of more effective, tolerable, and durable immunotherapy.
About Eftilagimod Alpha (Efti)
proprietary soluble LAG-3 protein and MHC Class II agonist that stimulates both innate and adaptive immunity for the treatment of cancer. As a first-in-class antigen presenting cell (APC) activator, efti binds to MHC (major histocompatibility complex) Class II molecules on APC leading to activation and proliferation of CD8+ cytotoxic T cells,
CD4+ helper T cells, dendritic cells, NK cells, and monocytes. It also upregulates the expression of key biological molecules like IFN- and CXCL10 that further
boost the immune system s ability to fight cancer.
Efti is under evaluation for a variety of solid tumours including non-small cell
lung cancer (NSCLC), head and neck squamous cell carcinoma (HNSCC), and HER2 /HR+ metastatic breast cancer. Its favourable safety profile enables various combinations, including with anti-PD-[L]1 immunotherapy and/or chemotherapy. Efti has received Fast Track Designation in 1st line HNSCC and in 1st line NSCLC from the United States Food and Drug Administration (FDA).
Immutep is a clinical stage biotechnology
company leading the development of LAG-3 related immunotherapy products for the treatment of cancer and autoimmune disease. The Company is dedicated to leveraging its technology and expertise to bring
innovative treatment options to market for patients and to maximise value to shareholders.
Immutep s lead product candidate is eftilagimod alpha
( efti or IMP321 ), a soluble LAG-3 fusion protein (LAG-3Ig), which is a
first-in-class antigen presenting cell (APC) activator being explored in cancer in multiple clinical trials. The Company is also developing an agonist of LAG-3 (IMP761) for autoimmune disease. Additional LAG-3 product candidates, including antibodies for immune response modulation, are licensed to and being developed by
Immutep s large pharmaceutical partners.
Further information can be found on the Company s website www.immutep.com or by contacting:
Australian Investors/Media:
+61 (0)406 759 268; cstrong@citadelmagnus.com
U.S. Investors/Media:
Chris Basta, VP, Investor
Relations and Corporate Communications
+1 (631) 318 4000; chris.basta@immutep.com
This announcement was authorised for release by the Board of Immutep Limited.
Immutep Limited, Level 33, Australia Square, 264 George Street, Sydney NSW 2000, Australia