ASX/Media Release Immutep Announces Abstract Highlighting Eftilagimod Alpha Selected for SITC 2022 Annual Meeting Press Conference Late-breaking abstract one of nine abstracts selected by SITC Communications Committee to

Immutep Announces Abstract Highlighting Eftilagimod Alpha Selected

for SITC 2022 Annual Meeting Press Conference

Late-breaking abstract one of nine abstracts selected by

SITC Communications Committee to be showcased at the SITC 2022 Press Conference

Company to host Webcast on Thursday, 10th November at 5 PM ET

to discuss data in Late-Breaking Oral Abstract Presentation

SYDNEY, AUSTRALIA 04 November 2022 Immutep Limited (ASX: IMM; NASDAQ: IMMP) ( Immutep or the

Company ), a clinical-stage biotechnology company developing novel LAG-3 immunotherapies for cancer and autoimmune disease, today announces its late-breaking abstract titled Combining the

antigen-presenting cell activator eftilagimod alpha (soluble LAG-3) and pembrolizumab: efficacy results from the 1st line non-small cell lung

cancer cohort of TACTI-002 (Phase II) has been selected by the Society for Immunotherapy of Cancer (SITC) Communications Committee to be presented at the SITC 2022 Annual Meeting Press

Of the more than 1,500 abstracts SITC received for its 37th annual meeting,

nine have been chosen for the SITC press conference that will be held virtually from 11:30 am - 1 pm ET on Tuesday, 8th November. Wade T. Iams, MD, Assistant Professor of Medicine,

Vanderbilt-Ingram Cancer Center Division of Hematology / Oncology, will provide a brief presentation on the late-breaking abstract for eftilagimod alpha ( efti ), a

first-in-class soluble LAG-3 protein, in combination with pembrolizumab in 1L NSCLC patients. He will also partake in a short

Q&A session with two SITC expert discussants.

Additional clinical data from the TACTI-002 Phase II trial will

be made available at 11:10 - 11:40 am ET on Thursday, 10th November, during Dr. Iams oral presentation.

Immutep also plans to hold a webcast after the presentation at SITC to discuss the data and results, as well as to provide an update on the Company s

business. Details are as follows:

Furthermore, as already announced, initial data from the INSIGHT-003 clinical trial

treating patients with various solid tumours with triple combination therapy of efti, anti-PD-1 therapy, and chemotherapy, will be presented in a poster presentation on

Friday, 11 November 2022. Additionally, a Trial in Progress poster on

Immutep Limited, Level 33, Australia Square

264 George Street, Sydney NSW 2000

the randomised Phase IIb TACTI-003 study of efti in combination with pembrolizumab as 1st line treatment of patients with recurrent or metastatic head and

neck squamous cell carcinoma will be presented on Thursday, 10 November 2022.

About Eftilagimod Alpha (Efti)

Efti is Immutep s proprietary soluble LAG-3 clinical stage candidate that is a first-in-class antigen presenting cell (APC) activator for the treatment of cancer, capitalising on LAG-3 s unique characteristics to stimulate both innate and

adaptive immunity. Efti binds to and activates antigen presenting cells via MHC II molecules leading to expansion and proliferation of CD8+ (cytotoxic) T cells, CD4+ (helper) T cells, dendritic cells, NK cells, and monocytes. It also upregulates the

expression of key biological molecules like CXCL10 that further boost the immune system s ability to fight cancer.

Efti is under evaluation for a

variety of solid tumours including non-small cell lung cancer (NSCLC), head and neck squamous cell carcinoma (HNSCC), and HER2 /HR+ metastatic breast cancer. Its favourable safety profile enables various

combinations, including with anti-PD-[L]1 immunotherapy and/or chemotherapy. Efti has received Fast Track Designation in 1st line HNSCC and in 1st line NSCLC from the

United States Food and Drug Administration (FDA).

Immutep is a clinical stage biotechnology company leading the development of LAG-3 related immunotherapy products for

the treatment of cancer and autoimmune disease. The Company is dedicated to leveraging its technology and expertise to bring innovative treatment options to market for patients and to maximise value to shareholders.

Immutep s lead product candidate is eftilagimod alpha ( efti or IMP321 ), a soluble LAG-3

fusion protein (LAG-3Ig), which is a first-in-class antigen presenting cell (APC) activator being explored in cancer in multiple

clinical trials. The Company is also developing an agonist of LAG-3 (IMP761) for autoimmune disease. Additional LAG-3 product candidates, including antibodies for immune

response modulation, are licensed to and being developed by Immutep s large pharmaceutical partners.

Further information can be found on the

Company s website www.immutep.com or by contacting:

Australian Investors/Media:

Catherine Strong, Citadel-MAGNUS

McCarthy, LifeSci Advisors

+1 (917) 679 9282; tim@lifesciadvisors.com

This announcement was authorised for release by the Board of Immutep Limited.

Immutep Limited, Level 33, Australia Square

264 George Street, Sydney NSW 2000