ASX/Media Release (Code: ASX: IMM; NASDAQ: IMMP) Immutep Announces Presentations at Society for Immunotherapy of Cancer (SITC) 2018 Annual Meeting SYDNEY, AUSTRALIA

ASX/Media Release (Code: ASX: IMM; NASDAQ: IMMP)

Immutep Announces Presentations at Society for Immunotherapy of Cancer (SITC) 2018 Annual Meeting

SYDNEY, AUSTRALIA October 2, 2018 Immutep Limited (ASX: IMM; NASDAQ: IMMP) ( Immutep or the

Company ), a biotechnology company developing novel immunotherapy treatments for cancer and autoimmune diseases, today announced that clinical data on the company s lead product candidate eftilagimod alpha ( efti or

IMP321 ), a soluble LAG-3Ig fusion protein based on the LAG-3 immune control mechanism, will be presented at the Society for Immunotherapy of Cancer (SITC)

Annual Meeting being held November 7-11, 2018, in Washington, D.C.

Abstract titles and authors are:

Title: Results from a Phase I dose escalation trial (TACTI-mel) with the soluble

LAG-3 protein (IMP321, eftilagimod alpha) together with pembrolizumab in unresectable or metastatic melanoma

Authors: Victoria Atkinson; Frederic Triebel; Christian Mueller; Chrystelle Brignone; Melissa Eastgate; Amitesh Roy; Adnan Khattak; Andrew Haydon

Title: A multicenter, phase II study in patients with first line NSCLC, or recurrent PD-X refractory NSCLC or

with recurrent HNSCC receiving Eftilagimod Alpha in combination with Pembrolizumab (TACTI-002)

Martin Forster; Frederic Triebel; Christian Mueller; Chrystelle Brignone; Tatsiana Skrahina

The exact time of Immutep s presentation and further

details will be available closer to the conference date.

Immutep is a globally active biotechnology company that is a leader in the development of immunotherapeutic products for the treatment of cancer and autoimmune

disease. Immutep is dedicated to leveraging its technology and expertise to bring innovative treatment options to market for patients and to maximize value to shareholders.

Immutep s current lead product is eftilagimod alpha ( efti or IMP321 ), a soluble LAG-3Ig

fusion protein based on the LAG-3 immune control mechanism. This mechanism plays a vital role in the regulation of the T cell immune response. Efti is currently in a Phase IIb clinical trial as a

chemoimmunotherapy for metastatic breast cancer termed AIPAC (clinicaltrials.gov identifier NCT 02614833); a Phase II clinical trial referred to as TACTI-002 (Two ACTive Immunotherapies) to evaluate a

combination of efti with KEYTRUDA (pembrolizumab) in several different solid tumours (clinicaltrials.gov identifier NCT03625323); and a Phase I combination therapy trial in metastatic

melanoma termed TACTI-mel (clinicaltrials.gov identifier NCT 02676869). Additional LAG-3 products, including antibodies, for immune response modulation in autoimmunity

and cancer are being developed by Immutep s large pharmaceutical partners. Immutep is also developing an agonist of LAG-3 (IMP761) for autoimmune disease.

Immutep is listed on the Australian Securities

Exchange (IMM), and on the NASDAQ (IMMP) in the United States.

Further information can be found on the Company s website www.immutep.com or

President of Business Development and Investor Relations, Immutep Limited

Garth Russell, LifeSci Advisors

+1 (646) 876-3613; garth@lifesciadvisors.com

Australian Investors/Media:

Matthew Gregorowski,

+61 2 8234 0105; mgregorowski@citadelmagnus.com