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Immunocore Holdings plc
Unaudited Condensed Consolidated Interim Financial Statements
Unaudited Condensed Consolidated Statements of Loss and Other Comprehensive Income
| Three months ended March 31, | ||||||||||||
| Notes | 2023 '000 | 2022 '000 | ||||||||||
| Product revenue, net | 3 | 42,052 | 7,682 | |||||||||
| Pre-product revenue, net | 3 | - | 2,829 | |||||||||
| Total revenue from sales of therapies | 42,052 | 10,511 | ||||||||||
| Collaboration revenue | 3 | 2,489 | 11,963 | |||||||||
| Total revenue | 44,541 | 22,474 | ||||||||||
| Cost of product revenue | (178 | ) | (248 | ) | ||||||||
| Research and development costs | (28,449 | ) | (18,581 | ) | ||||||||
| Selling and administrative expenses | 4 | (33,301 | ) | (20,105 | ) | |||||||
| Operating loss | (17,387 | ) | (16,460 | ) | ||||||||
| Finance income | 5 | 2,546 | 10 | |||||||||
| Finance costs | (1,620 | ) | (1,333 | ) | ||||||||
| Net finance income / (costs) | 926 | (1,323 | ) | |||||||||
| Loss before taxation | (16,461 | ) | (17,783 | ) | ||||||||
| Income tax (charge) / credit | 6 | (236 | ) | 1,655 | ||||||||
| Loss for the period | (16,697 | ) | (16,128 | ) | ||||||||
| Other comprehensive income | ||||||||||||
| Other comprehensive income that is or may be reclassified to profit or loss in subsequent periods: | ||||||||||||
| Exchange differences on translation of foreign operations | 380 | 205 | ||||||||||
| Total other comprehensive income for the period | 380 | 205 | ||||||||||
| Total comprehensive loss for the period | (16,317 | ) | (15,923 | ) | ||||||||
| Basic and diluted loss per share - | 7 | (0.35 | ) | (0.37 | ) |
The accompanying notes form part of these unaudited condensed consolidated interim financial statements.
Immunocore Holdings plc
Unaudited Condensed Consolidated Interim Financial Statements
Unaudited Condensed Consolidated Statements of Financial Position as at
| Notes | March 31, 2023 '000 | December 31, 2022 '000 | ||||||||||
| Non-current assets | ||||||||||||
| Property, plant and equipment | 8 | 8,156 | 6,472 | |||||||||
| Intangible assets | 410 | 410 | ||||||||||
| Right of use assets | 24,742 | 25,173 | ||||||||||
| Other non-current assets | 7,033 | 7,342 | ||||||||||
| Deferred tax asset | 6 | 4,285 | 4,240 | |||||||||
| Total non-current assets | 44,626 | 43,637 | ||||||||||
| Current assets | ||||||||||||
| Inventory | 882 | 943 | ||||||||||
| Trade and other receivables | 9 | 45,200 | 46,711 | |||||||||
| Tax receivable | 6 | 2,365 | 11,688 | |||||||||
| Cash and cash equivalents | 337,461 | 332,539 | ||||||||||
| Total current assets | 385,908 | 391,881 | ||||||||||
| Total assets | 430,534 | 435,518 | ||||||||||
| Equity | ||||||||||||
| Share capital | 10 | 97 | 97 | |||||||||
| Share premium | 128,744 | 123,751 | ||||||||||
| Foreign currency translation reserve | (2,717 | ) | (3,097 | ) | ||||||||
| Other reserves | 337,847 | 337,847 | ||||||||||
| Share-based payment reserve | 11 | 88,072 | 81,411 | |||||||||
| Accumulated deficit | (277,950 | ) | (261,253 | ) | ||||||||
| Total equity | 274,093 | 278,756 | ||||||||||
| Non-current liabilities | ||||||||||||
| Non-current accruals | 824 | 1,479 | ||||||||||
| Interest-bearing loans and borrowings | 38,677 | 39,500 | ||||||||||
| Deferred revenue | 3 | 4,331 | 4,331 | |||||||||
| Lease liabilities | 27,822 | 28,248 | ||||||||||
| Provisions | 125 | 114 | ||||||||||
| Total non-current liabilities | 71,779 | 73,672 | ||||||||||
| Current liabilities | ||||||||||||
| Trade and other payables | 12 | 78,158 | 75,076 | |||||||||
| Deferred revenue | 3 | 4,806 | 6,408 | |||||||||
| Lease liabilities | 1,636 | 1,555 | ||||||||||
| Provisions | 62 | 51 | ||||||||||
| Total current liabilities | 84,662 | 83,090 | ||||||||||
| Total liabilities | 156,441 | 156,762 | ||||||||||
| Total equity and liabilities | 430,534 | 435,518 |
The accompanying notes form part of these unaudited condensed consolidated interim financial statements.
Immunocore Holdings plc
Unaudited Condensed Consolidated Interim Financial Statements
Unaudited Condensed Consolidated Statements of Changes in Equity
| Notes | Share capital '000 | Share premium '000 | Foreign currency translation reserve '000 | Share- based payment reserve '000 | Other reserve '000 | Accumulated deficit '000 | Total equity '000 | |||||||||||||||||||||||||
| At January 1, 2023 | 97 | 123,751 | (3,097 | ) | 81,411 | 337,847 | (261,253 | ) | 278,756 | |||||||||||||||||||||||
| Loss for the period | - | - | - | - | - | (16,697 | ) | (16,697 | ) | |||||||||||||||||||||||
| Other comprehensive income | - | - | 380 | - | - | - | 380 | |||||||||||||||||||||||||
| Total comprehensive loss for the period | - | - | 380 | - | - | (16,697 | ) | (16,317 | ) | |||||||||||||||||||||||
| Exercise of share options | 11 | - | 4,993 | - | - | - | - | 4,993 | ||||||||||||||||||||||||
| Equity-settled share-based payment transactions | 11 | - | - | - | 6,661 | - | - | 6,661 | ||||||||||||||||||||||||
| At March 31, 2023 | 97 | 128,744 | (2,717 | ) | 88,072 | 337,847 | (277,950 | ) | 274,093 |
| Notes | Share capital '000 | Share premium '000 | Foreign currency translation reserve '000 | Share- based payment reserve '000 | Other reserve '000 | Accumulated deficit '000 | Total equity '000 | |||||||||||||||||||||||||
| At January 1, 2022 | 88 | 212,238 | 89 | 54,357 | 386,167 | (481,392 | ) | 171,547 | ||||||||||||||||||||||||
| Loss for the period | - | - | - | - | - | (16,128 | ) | (16,128 | ) | |||||||||||||||||||||||
| Other comprehensive income | - | - | 205 | - | - | - | 205 | |||||||||||||||||||||||||
| Total comprehensive loss for the period | - | - | 205 | - | - | (16,128 | ) | (15,923 | ) | |||||||||||||||||||||||
| Exercise of share options | 11 | - | 261 | - | - | - | - | 261 | ||||||||||||||||||||||||
| Equity-settled share-based payment transactions | 11 | - | - | - | 7,413 | - | - | 7,413 | ||||||||||||||||||||||||
| At March 31, 2022 | 88 | 212,499 | 294 | 61,770 | 386,167 | (497,520 | ) | 163,298 |
The accompanying notes form part of these unaudited condensed consolidated interim financial statements.
Immunocore Holdings plc
Unaudited Condensed Consolidated Interim Financial Statements
Unaudited Condensed Consolidated Statements of Cash Flows
| Three Months Ended March 31, | ||||||||||||
| Notes | 2023 '000 | 2022 '000 | ||||||||||
| Cash flows from operating activities | ||||||||||||
| Loss for the period | (16,697 | ) | (16,128 | ) | ||||||||
| Adjustments for: | ||||||||||||
| Equity settled share-based payment expense | 11 | 6,661 | 7,413 | |||||||||
| Depreciation | 1,285 | 1,679 | ||||||||||
| Net finance (income) / costs | (926 | ) | 1,323 | |||||||||
| Foreign exchange movements | 5,725 | 945 | ||||||||||
| Other | (18 | ) | (1 | ) | ||||||||
| Income tax charge / (credit) | 6 | 236 | (1,655 | ) | ||||||||
| Working capital adjustments: | ||||||||||||
| Decrease / (increase) in receivables and other non-current assets | 2,852 | (11,489 | ) | |||||||||
| Increase / (decrease) in trade and other payables | 2,111 | (807 | ) | |||||||||
| Decrease in deferred revenue | (1,602 | ) | (11,633 | ) | ||||||||
| Other working capital movements | (562 | ) | (480 | ) | ||||||||
| Cash used in operations | (935 | ) | (30,833 | ) | ||||||||
| Taxation received | 6 | 9,904 | - | |||||||||
| Taxation paid | 6 | (177 | ) | - | ||||||||
| Net cash from / (used in) operating activities | 8,792 | (30,833 | ) | |||||||||
| Cash flows from investing activities | ||||||||||||
| Proceeds from sale of property, plant and equipment | - | 5 | ||||||||||
| Purchase of property, plant and equipment | 8 | (2,470 | ) | (138 | ) | |||||||
| Interest received | 2,076 | - | ||||||||||
| Net cash flows used in investing activities | (394 | ) | (133 | ) | ||||||||
| Cash flows from financing activities | ||||||||||||
| Exercise of share options | 11 | 4,993 | 261 | |||||||||
| Interest paid | (2,101 | ) | (838 | ) | ||||||||
| Repayment of lease liabilities | (407 | ) | (755 | ) | ||||||||
| Net cash flows from / (used in) financing activities | 2,485 | (1,332 | ) | |||||||||
| Increase / (decrease) in cash and cash equivalents | 10,883 | (32,298 | ) | |||||||||
| Net foreign exchange difference on cash held | (5,961 | ) | 265 | |||||||||
| Cash and cash equivalents at beginning of the period | 332,539 | 237,886 | ||||||||||
| Cash and cash equivalents at end of the period | 337,461 | 205,853 |
The accompanying notes form part of these unaudited condensed consolidated interim financial statements.
Immunocore Holdings plc
Unaudited Condensed Consolidated Interim Financial Statements
Notes to the Financial Statements
1. Organization and nature of business
Immunocore Holdings plc (the "Company") is a public limited company incorporated in England and Wales and has the following wholly owned subsidiaries:
Immunocore Limited, Immunocore LLC, Immunocore Commercial LLC, Immunocore Ireland Limited, Immunocore GmbH, and Immunocore Nominees Limited (collectively referred to as the "Group").
The Company's American Depositary Shares ("ADSs") began trading on the Nasdaq Global Select Market under the ticker symbol "IMCR" on February 5, 2021,
following its initial public offering ("IPO"). The IPO and concurrent private placement generated net proceeds of 210,985,000 after underwriting discounts, commissions and directly attributable offering expenses. In July 2022, the Company raised
116,812,000 ($140,000,000) before deductions for offering expenses of 388,000 through the sale of its ordinary shares in the form of ADSs and non-voting ordinary shares in a private placement.
The principal activity of the Group is pioneering the development and sale of a novel class of TCR bispecific immunotherapies called ImmTAX - Immune mobilizing monoclonal TCRs Against X disease - designed to treat a broad range of diseases, including cancer, infectious and autoimmune diseases. Leveraging its proprietary, flexible, off-the-shelf ImmTAX
platform, the Group is developing a deep pipeline in multiple therapeutic areas, including four clinical stage programs in oncology and infectious disease, advanced pre-clinical programs in autoimmune disease and multiple earlier pre-clinical
In January and April 2022, the Group received approval from the U.S. Food and Drug Administration ("FDA") and European Commission ("EC"),
respectively, for its lead product, KIMMTRAK, for the treatment of unresectable or metastatic uveal melanoma ("mUM"). In June 2022, the UK's MHRA, Health Canada, and the Australian Government Department of Health's TGA have each approved KIMMTRAK
for the treatment of HLA-A*02:01-positive adult patients with unresectable or mUM. KIMMTRAK is now approved in over 30 countries and the Group has commercially launched in the United States, Germany and France, among other territories,
with further commercial launches underway in additional territories where it has received approval. The Group expects to obtain regulatory approval for KIMMTRAK in further territories in 2023.
2. Significant accounting policies
Basis of preparation and statement of compliance
The unaudited condensed consolidated interim financial statements as at and for the three months ended March 31, 2023
and 2022 have been prepared in accordance with International Accounting Standard 34, "Interim Financial Reporting" ("IAS 34"). Except as described in Significant Accounting Policies below, the accounting policies, including the Group's Critical
accounting estimates, applied in these interim financial statements are the same as those applied in the Group's consolidated financial statements as at and for the year ended December 31, 2022.
The unaudited condensed consolidated interim financial
statements do not include all of the information required for the full annual financial statements and should be read in conjunction with the annual consolidated financial statements of the Group for the year ended December 31, 2022 included in
the Company's Annual Report on Form 20-F for the year ended December 31, 2022, filed with the Securities and Exchange Commission on March 1, 2023 (the "Annual Report"). There were no significant new accounting policies or critical accounting
estimates applicable to the three months ended March 31, 2023.
The unaudited condensed consolidated interim financial statements have been prepared under the historical cost basis, as modified by the recognition of certain financial instruments measured at fair
value and are presented in pounds sterling which is the Company's functional currency. All values are rounded to the nearest thousand, except where otherwise indicated.
Date of authorization
These unaudited condensed consolidated interim financial statements were prepared at the request of the Company's Board of Directors (the "Board") and were approved by the Board on May 10, 2023, and
signed on its behalf by Dr. Bahija Jallal, Chief Executive Officer of the Group.
Adoption of new accounting standards
There have been no new accounting standards adopted by the Group in the three months ended March 31, 2023 which have had a material impact on these unaudited condensed consolidated interim financial
statements. There are no standards issued but not yet effective that the Group expects to have a material impact on its financial statements.
The Group reported cash and cash equivalents of 337,461,000 and net current assets of 301,246,000 as at March 31, 2023, with an operating loss for the three months ended March 31, 2023 of
17,387,000 and net cash from operating activities for the three months ended March 31, 2023 of 8,792,000. The positive operational cash inflow was largely due to R&D tax credits received and net product revenue of 42,052,000 during the three
months ended March 31, 2023.
In assessing the going concern assumptions, the Board has undertaken an assessment of the current business and strategy forecasts covering a twelve month
period, which includes anticipated KIMMTRAK revenue. In assessing the downside risks, the Board has also considered scenarios incorporating a range of revenue arising from KIMMTRAK sales. As part of considering the downside risks, the Board has
considered the impact of the current macroeconomic environment, such as the effects of COVID-19 or other pandemics and other potential economic impacts including the war in Ukraine and related geopolitical tensions, as well as global inflation,
liquidity concerns at banks and financial institutions, capital market instability, interest and exchange rate fluctuations, and increases in commodity, energy and fuel prices as well as supply chain disruptions. The Board has concluded that while
these may have a future impact on the Group's business and implementation of its strategy and plans, it anticipates that any such impact will be minimal on clinical trials or other business activities over the period assessed for going concern
purposes. As of the date of these financial statements, the Group is not aware of any specific event or circumstance that would require the Group to update its estimates, assumptions and judgments or revise the carrying value of its assets or
liabilities. Actual results could differ from these estimates, and any such differences may be material to the Group's financial statements.
Given the current cash position and the assessment performed, the Board believes that the Group will have sufficient funds to continue to meet its liabilities as they fall due for a
period of at least twelve months from the date of issue of these condensed consolidated financial statements and therefore, the Group has prepared the financial statements on a going concern basis. This scenario is based on the Group's
lower range of anticipated revenue levels. As the Group continues to incur significant expenses in the pursuit of its business strategy, including further commercialization and marketing plans for KIMMTRAK,
additional funding will be needed before further existing clinical and preclinical programs may be expected to reach commercialization, which would potentially lead to additional operational cash inflows. Until the Group can generate revenue from
product sales sufficient to fund its ongoing operations and further develop its pipeline, if ever, it expects to finance its operations through a combination of public or private equity offerings and debt financings or other sources, such as
potential collaboration agreements, strategic alliances and licensing arrangements.
Estimates and judgements
The preparation of the unaudited condensed consolidated interim financial statements in conformity with IAS 34 requires management to make judgments, estimates and assumptions. These
judgments, estimates and assumptions affect the reported assets and liabilities as well as contingent liabilities and income and expenses in the financial period. The estimates and associated assumptions are based on information available when
the unaudited condensed consolidated interim financial statements are prepared, historical experience and various other factors which are believed to be reasonable under the circumstances the results of which form the basis of making
judgments about the carrying values of assets and liabilities that are not readily apparent from other sources. Existing circumstances and assumptions about future developments, however, may change due to market
changes or circumstances arising that are beyond the Group's control. Hence, estimates may vary from the actual values. The estimates and underlying assumptions are reviewed on an ongoing basis. Revisions to accounting estimates are recognized in
the period in which the estimate is revised if the revision affects only that period or the period of revision and future periods if this revision affects both current and future periods.
Judgements and estimates made, including Critical accounting estimates, together with the Group's significant accounting policies, are disclosed in the consolidated financial statements of the Group
for the year ended December 31, 2022, and are presented in the Group's Annual Report. There have been no significant updates to the Group's estimates and accounting policies for the three months ended March 31, 2023.
The Group operates in one operating segment. The Group's chief operating decision maker (the, "CODM"), its Chief Executive Officer, manages the Group's operations on an integrated basis for the purposes of allocating
Revenue is presented by type, and net of deductions outlined in the Group's accounting policies, in the table below. The Group's accounting policies are disclosed in the consolidated financial
statements of the Group for the year ended December 31, 2022, and are presented in the Group's Annual Report.
| For the three months ended March 31, | ||||||||
| 2023 '000 | 2022 '000 | |||||||
| Product revenue, net | 42,052 | 7,682 | ||||||
| Pre-product revenue, net | - | 2,829 | ||||||
| Total revenue from sale of therapies | 42,052 | 10,511 | ||||||
| Collaboration revenue | ||||||||
| Eli Lilly | - | 7,361 | ||||||
| Genentech | 2,489 | 4,602 | ||||||
| Total collaboration revenue | 2,489 | 11,963 | ||||||
| Total revenue | 44,541 | 22,474 |
Of the Group's collaboration customers, Eli Lilly and Genentech are based in the United States. Net product revenue from the sale of KIMMTRAK, and net pre-product revenue from the sale of tebentafusp as part
of a compassionate use and early access program are presented by region based on the location of the customer below.
| For the three months ended March 31, | ||||||||
| 2023 '000 | 2022 '000 | |||||||
| United States | 29,533 | 7,682 | ||||||
| Europe | 12,328 | 2,829 | ||||||
| Rest of the World | 191 | - | ||||||
| Total revenue from the sale of therapies | 42,052 | 10,511 |
Product revenue, net
During the three months ended March 31, 2023, the Group recognized 42,052,000 of net product revenue (for the three months ended March 31, 2022: 7,682,000), relating to the sale of KIMMTRAK
primarily in the United States and Europe after estimated deductions for rebates, chargebacks, other customer fees and returns.
Pre-product revenue, net
There was no pre-product revenue during the three months ended March 31, 2023, following the transition to the commercial sale of KIMMTRAK in France in the second half of 2022. In the three months
ended March 31, 2022, the Group recognized 2,829,000 of net pre-product revenue relating to the sale of tebentafusp under a compassionate use program in France after estimated deductions for rebates and returns.
Genentech Collaboration
During the three months ended March 31, 2023, the Group recognized 2,489,000 of revenue relating to the 2018 Genentech Agreement and IMC-C103C (for the three months ended March 31, 2022: 4,602,000).
Of the revenue recognized during the three months ended March 31, 2023, 887,000 of revenue represents cost reimbursements, predominantly for clinical trial costs. For the three months ended March 31, 2022, the Group recognized cost reimbursements
In February 2023, Genentech accepted the Group's proposal to cease co-funding the development of MAGE-A4 HLA-A02 targeted programs, except with respect to sharing equally the wind-down costs of the IMC-C103C Phase 1
clinical trial. The Group is eligible to receive development and commercial milestone payments plus royalties from Genentech on any sales of MAGE-A4 HLA-A02 targeted products arising under the Genentech Agreement.
Eli Lilly Collaboration
During the three months ended March 31, 2023, the Group recognized no revenue relating to the Eli Lilly Agreement (for the three months ended March 31, 2022: 7,361,000).
The Group released the remaining deferred revenue attributed to the third target under the collaboration after the parties agreed to terminate the agreement during the three months ended March 31,
2022. No further revenue under the collaboration is expected.