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progress, results, and cost of our research and development programs and our current and future preclinical and clinical studies, including statements regarding the timing of initiation and completion of studies or trials and related preparatory
work, the period during which the results of the trials will become available, and our research and development programs; our ability to efficiently discover and develop product candidates; our ability to initiate, recruit and enroll patients in and
conduct our clinical trials at the pace that we project; our ability to obtain and maintain regulatory approval of our product candidates; our ability to compete with companies currently marketing or engaged in the development of treatments that our
product candidates are designed to target; our reliance on third parties to conduct our clinical trials and to manufacture drug substance for use in our clinical trials; the size and growth potential of the markets for our product candidates and our
ability to serve those markets; the ability and willingness of our third-party strategic collaborators to continue research and development activities relating to our development candidates and product candidates; our ability to obtain and maintain
adequate intellectual property rights; our estimates of our future expenses, revenue, capital requirements or our need for or ability to obtain additional financing; our expected uses of the net proceeds to us from this offering; the potential
benefits of strategic collaboration agreements, our ability to enter into additional strategic collaborations or arrangements, and our ability to attract collaborators with development, regulatory and commercialization expertise; our financial
performance; developments and projections relating to our competitors or our industry; the effect of the COVID-19 pandemic, including mitigation efforts and economic effects, on any of the foregoing or other
aspects of our business operations, including but not limited to our preclinical studies or current and future clinical trials. We caution the recipient not to place considerable reliance on the forward-looking statements contained in this
presentation. The forward-looking statements in this Presentation speak only as of the date of this document, and we undertake no obligation to update or revise any of these statements. Our business is subject to substantial risks and uncertainties,
including those referenced above. Certain information contained in this Presentation relates to or is based on estimates, projections and other information concerning the Company s industry, its business and the markets for its programs and
product candidates and studies, publications, surveys and other data obtained from third-party sources and the Company s own internal estimates and research. While the Company believes these third-party sources to be reliable as of the date of
this Presentation, it has not independently verified, and makes no representation as to the adequacy, fairness, accuracy or completeness of, any information obtained from third-party sources. In addition, all of the market data included in this
Presentation involves a number of assumptions and limitations, and there can be no guarantee as to the accuracy or reliability of such assumptions. Finally, while we believe our own internal research is reliable, such research has not been verified
by any independent source.
These forward-looking statements are based on the beliefs of our management as well as assumptions made by and information currently
available to us. Although we believe the expectations reflected in such forward-looking statements are reasonable, we can give no assurance that such expectations will prove to be correct. If such assumptions do not fully materialize or prove
incorrect, the events or circumstances referred to in the forward-looking statements may not occur. We undertake no obligation to update publicly any forward-looking statements for any reason after the date of this presentation to conform these
statements to actual results or to changes in our expectations, except as required by law. Accordingly, readers are cautioned not to place undue reliance on these forward-looking statements. Additional risks and uncertainties that could affect our
business are included under the caption Risk Factors in our most recent report filed with the Securities and Exchange Commission.
Developing Biology-Driven Medicines and Expanding the Impact of Targeted Oncology for Patients Ikena Mission
Patient-driven drug development targeting oncogenic drivers and pathways of therapeutic resistance
Using known and novel biomarkers and approaches for targeted therapy development and patient identification By the Numbers
3 programs in clinical development or clinic-ready 2 programs partnered with oncology partner of choice, BMS
Multiple targeted oncology programs in discovery across 2 key pathways 60 diverse, experienced team members $264M in cash; Runway through 2023 Current Focus Targeted Oncology Hippo
Pathway RAS Pathway Immune-signaling in the tumor-microenvironment
Pipeline of Biomarker-Defined Therapies Designed to Improve Patient Outcomes
Program Late-Stage Indications Discovery IND Enabling Phase 1 Target Development
IK-930 Hippo-mutated TEAD cancers Multiple RAS Pathway RAS-mutated Targets; Including ERK5 cancers Bladder cancer IK-175 + Nivo AHR BMS
Additional tumor types IK-412 Multiple solid
Kynurenine BMS tumors IK-007 + Pembro MSS-CRC EP4
Targeting TEAD & the Hippo Pathway IK-930
Patients with Hippo-Driven Cancers Could Benefit from IK-930 Monotherapy
Hippo landscape is developing; the identification of additional related indications continues
~125,000 newly diagnosed cancer patients per year in the US with hippo pathway mutations and alteration
Malignant Mesothelioma: ^ 40% have NF2 loss of function mutations NSCLC: 6% YAP1 and 29% TAZ amplification
Meningioma: High frequency of NF2 deficiency; Most common CNS tumor, accounting for ^ one-third of primary CNS tumors
Head & Neck Cancers: Growing body of knowledge on frequent YAP/TAZ amplification and FAT1 (upstream) deficiency
Soft Tissue Sarcomas:
^ 90% of epithelioid hemangioendothelioma, or EHE, have TAZ-CAMTA1 fusions; 10% of EHE have YAP1-TFE3 fusions NF2 MST1/2 LATS1/2 YAP1/TAZ TEAD
IK-930 is an Oral, Selective, Potent TEAD Inhibitor
IK-930 was well tolerated preclinically while showing significant impact on TEAD dependent gene expression
Robust Inhibition TEAD Target
Potent TEAD Inhibition Selective Activity in Hippo-Mutated Cells
Gene Expression expression proliferation
CNN1 ANKRD1 CTGF NPPB AMOTL2 CYR61
IK-930 IK-930 DMSO low high
TEAD activated cell line
1.5 1.0 Proliferation 0.5 0.0 10-3 10-2 10-1 100 101 102
IK-930 Concentration ( M) Control NF2 KO
100 80 Inhibition 60 40 % 20 0 10-4 10-3 10-2 10-1 100 101 IK-930 Concentration ( M)
IK-930 Monotherapy Has Potential Across Genetic Mutations in the Hippo Pathway
Impact Across Tumor Models
1500 Vehicle Vehicle
IK-930 30 mg/kg QD IK-930 30 mg/kg QD Vehicle
IK-930 200 mg/kg QD IK-930 75 mg/kg QD IK-930 75 mg/kg QD
Volume IK-930 200 mg/kg QD Volume
Volume SEM) SEM) SEM) 1000 -
Tumor (mm3+/ 500 (mm3+/ (mm3+/ Average Average 500 Average 500
0 5 10 15 20 25 0 5 10 15 20 25 0 5 10 15 20 25
initiation Days post treatment initiation Days post treatment initiation
NF2 Deficient Mesothelioma Model LATS1/LATS2 Mutated Mesothelioma Model YAP1 Amplified
Robust Translational Data to Drive Indication Selection
Top 10: Hippo Alterations
NSLC SQ Cholangiocarcinoma
Uterine Carcinosarcoma Esophageal CA
Top 10: YAP/TAZ Activity Score
Esophageal CA Kidney Clear Cell Sarcoma
NSCLC AD Cholangiocarcinoma NSCLC SQ
YAP/TAZ Nuclear Localization High YAP1 nuclear protein expression indicative of pathway activation in select indications
First-in-Human Trial Monotherapy Targeting Hippo-Driven Cancers
Clinical Trial Design
Tumors known to have high incidence of
Hippo pathway alterations
Cohort 1: NF2 deficient mesothelioma
Cohort 2: NF2 deficiency tumor agnostic
Cohort 3: Epithelioid
hemangioendothelioma (EHE)
Cohort 4: YAP or TAZ gene fusion tumor agnostic
Hippo Pathway Engagement in Therapeutic Resistance and Tumor Escape
Combining IK-930 with other
targeted therapies has the potential to combat therapeutic resistance
Resistance to multiple targeted therapies and tumor recurrence can
be linked to YAP/TEAD activation
Overcoming resistance mechanisms and escape could not only
deepen and prolong responses but could address de novo resistance, allowing more patients to respond to target therapies overall
Targeted-Therapy Treated EGFRm NSCLC Shows Potential for IK-930 Combo Benefit
EGFR Inhibitor Promotes YAP1 Nuclear Localization
IK-930 Combo with MEKi & EGFRi in EGFRm NSCLC Model Shows Significant Increase in Targeted Apoptosis
OsimertinibIF: -YAP1
Apoptosis 1500 OT+930 0.1 M
Normalized Osi + Tra Osi 50 nM
Tra 30 nM 930 1 M Vehicle