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Disease-Modifying Therapeutics for Neurodegenerative Disease, Cancer and Cardiopulmonary Disease Inhibikase.com : IKT
DISCLAIMER This presentation shall not constitute an offer to sell or a
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of any such state or jurisdiction. This presentation contains information that may constitute "forward-looking statements" within the meaning of Section 27A of the Securities Act, and Section 21E of the Securities Exchange Act of 1934,
as amended. Inhibikase Therapeutics, Inc. (the "Company" or "we") intends for the forward-looking statements to be covered by the safe harbor provisions for forward-looking statements in those sections. Generally, we have
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forward-looking statements are set forth in the Company's filings with the Securities and Exchange Commission, including its annual report on Form 10-K and its quarterly Form 10-Q, including under the caption Risk Factors". We do not
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OFFERING SUMMARY Inhibikase Therapeutics, Inc. ("IKT" or the
"Company") ISSUER: Nasdaq Capital Market: IKT EXCHANGE/SYMBOL: Best Efforts S-1 Follow-on OFFERING TYPE: Up to $13.0 Million GROSS PROCEEDS: Units consisting of one share of Common Stock (or one Pre-Funded Warrant in lieu SECURITIES TO
BE thereof), and one Warrant to purchase one share of common stock OFFERED: To extend the 201 trial for Risvodetinib (IkT-148009) up to an additional 12 months, ANTICIPATED USE OF support expansion of their biomarker program and ancillary studies
required for Phase PROCEEDS: 3 entry and other general corporate purposes Maxim Group LLC SOLE PLACEMENT AGENT: Week of April 29, 2024 ANTICIPATED PRICING: Inhibikase.com : IKT 3
MULTI-THERAPEUTIC PIPELINE OF KINASE INHIBITOR THERAPEUTICS Developing
innovative medicines across the therapeutic spectrum Multi-therapeutic pipeline across neurodegenerative disease, cancer and cardiopulmonary disease Risvodetinib (IkT-148009): Selective c-Abl inhibitor. Phase 2 ongoing to evaluate
disease modification in Parkinson's disease. Phase 2 201 trial, 77% enrolled in the U.S. 12-week trial planned to be extended by up to 12 additional months, subject to additional resources. Blinded functional and biomarker data support
continuation and expansion of trial. $12B+ 1 global addressable market. IkT-001Pro: Prodrug of imatinib mesylate. Phase 3 complete in blood and stomach cancers, Phase 2/3 ready in 2 Pulmonary Arterial Hypertension. $7B+ global addressable
market. Robust patent portfolio with compositions of matter protected to 2033 (IkT-001Pro) and 2036 (risvodetinib). Orphan designations: Rivsodetinib in Multiple System Atrophy, IkT-001Pro in multiple oncology indications and
pulmonary arterial hypertension. Cash/cash equivalent runway into 1Q25. Highly-experienced management team, consultants, Board of Directors and Scientific Advisory Board. 1 ; 2 Vision Research, 2022 ; From Biomedtracker (Citeline
Commercial), 2024 (https://www.biomedtracker.com/indicationreport.cfm?indid=245#PipelineChart) Inhibikase.com : IKT 4
COMPANY HIGHLIGHTS: MULTI-THERAPEUTIC PIPELINE Multi-Indication Pipeline
in Neurodegeneration, Oncology and Non-oncology Indications 1 CLINICAL DEVELOPMENT (1). Clinical Development' progress PRECLINICAL bars represent the current state of the DRUG TARGET DRUG CANDIDATE MODALITY DISEASE INDICATION PHASE 1/1B
PHASE 2 PHASE 3 DEVELOPMENT indicated programs. Blue arrows represent completed or in progress studies; white arrows represent planned Neurodegeneration approaches for future clinical studies. Parkinson's Disease: (2). Four indications will be
pursued for c-Abl Risvodetinib Small molecule Treatment Naive IkT-148009 in PD, which will be pursued through studies of treatment na ve and early-stage patients, Parkinson's Disease: c-Abl Risvodetinib Small molecule including their GI
complications. MSA is 4 Indications Pursued Early Stage an orphan, aggressive form of Through 2 INDs. Shares Parkinson's-like disease to enter clinical 2 Same Phase 1 and 2 c-Abl Risvodetinib Small molecule Neurogenic Constipation development
at Phase 2 following completion and positive outcomes from animal model studies of IkT-148009 in c-Abl Risvodetinib Small molecule Dysphagia prophylactic and therapeutic dosing studies. Pursued through open c-Abl Risvodetinib Small molecule Multiple
System Atrophy IND in the US and future EMA filing in EU Oncology BCR-Abl IkT-001Pro Small molecule Stable-phase CML (orphan indication) 505(b)(2) Path to Market Cardiopulmonary disease IND to be filed May, 2024 to c-Abl IkT-001Pro Small molecule
Pulmonary Arterial Hypertension initiate Phase 2/3 study Research c-Abl IkT-148x, BIP4-7 Small molecule Dementia with Lewy Body c-Abl IkT-148x, BIP4-7 Small molecule Multiple System Atrophy Inhibikase.com : IKT 5
Parkinson's and Related Disorders Parkinson's Disease
Market & Strategy Inhibikase.com : IKT 6
THE MARKET: DISEASE-MODIFICATION WILL TRANSFORM TREATMENT PARADIGM 1
Parkinson's disease and MSA in the U.S. Parkinson's: Slowly Progressing MSA: Rapidly Progressing 1/3 of a Patient's Lifespan to death = 25 years 1/10 of a Patient's Lifespan to death = 8 years Global treatment sales for PD by
2030 are expected 90,000 38,000 15,000 -50,000 to exceed New Cases / Year Deaths / Year Cases 930,000 - 1,200,000 Orphan Disease $12.2 BILLION 1 U.S. Patients Vision Research, 2022 60 55 Current treatments Average Age Of Onset Average Age Of
Onset cannot alter course of Parkinson's disease Co-morbid indications MSA has no beneficial Men twice treatments as likely as The country with the highest women to diagnosed prevalence is contract 47% 30% 35% 36% THE U.S. disease Arthritis
Heart/Circulatory Psychosis Dementia Vision Research, 2022 1 Parkinson's Disease Foundation Decisions Resources 2016, Lewin Report in the Economic Burden and Future Impact of Parkinson's disease, 2019. Inhibikase.com : IKT
1 SEARCHING FOR THE ROLE OF THE MISFOLDED PROTEIN IN MAJOR CNS DISEASE
Different proteins, similar pathological effect b-amyloid and Tau in Alzheimer's a-synuclein in PD, MSA, DLB What role does the misfolded protein play? 1 Nat. Neurosci. 21: 1332-1340 (2018) Inhibikase.com : IKT 8
EXTERNAL OR INTERNAL AS A SITE OF TARGETING? antibody or Clearance of
pathological plaque unknown dis-aggregator targets plaque NOT restorative outside affected neurons mechanistic inhibitors Does clear pathological plaques like risvodetinib CAN BE restorative target plaque inside affected neurons 1
Risvodetinib targets an enzyme, c-Abl, inside the neurons at the site of disease initiation 1 Werner and Olanow , Mov Disorders 2021, doi: 10.1002/mds.28858 Karuppagounder, Werner, et al., Sci Transl. Med 2023 doi: 10.1126/scitranslmed.abp9352
Inhibikase.com : IKT 9
RISVODETINIB MODIFIES PARKINSON'S DISEASE c-Abl inhibition by
Risvodetinib restores lost function in Validated Animal 1 Models of Parkinson's disease a Neurodegeneration Motor Dysfunction -Synuclein Toxicity Neuroinflammation preserves restores clears suppresses as much as 85% as much as 90% to baseline
in the to near baseline of brain neurons of lost function organs of disease in the organs of disease 1 Werner and Olanow , Mov Disorders 2021, doi: 10.1002/mds.28858 Karuppagounder, Werner, et al., Sci Transl. Med 2023 doi:
10.1126/scitranslmed.abp9352 Inhibikase.com : IKT 10
The 201 Trial evaluating Risvodetinib in Untreated Parkinson's
Disease Inhibikase.com : IKT 11
The 201 TRIAL: TRIAL DESIGN AND PATIENT FLOW or 92 As of April 23, 2024
or Inhibikase.com : IKT 12
THE 201 TRIAL; POSSIBLY RISVODETINIB-RELATED ADVERSE EVENTS AS OF APRIL
23, 2024 Adverse Event Severity (# Occurrences) Gastrointestinal Nausea (1) Mild Vomiting (3) Mild (3) 25 AEs occurred in 17 of Gas/Cramps (2) Mild (1)/Moderate (1) 92 enrolled participants Heartburn (1) Mild Diarrhea (3) Mild Constipation (1) Mild
Cardiovascular Abnormal ECG (2) Mild Orthostatic hypotension (2) Mild Laboratory Elevated lipase (1) Mild Elevated creatinine (1) Mild Psychological/Neurological Irritability (1) Mild Headache (2) Mild Increase energy (1) Mild Worsening Parkinsonism
(1) Moderate (non-compliant dosing) Musculoskeletal Fatigue (2) Mild Rash (1) Mild Inhibikase.com : IKT 13
201 TRIAL: EARLY UNBLINDED OBSERVATIONS Functional Assessment:
Universal Parkinson's Disease Rating Scale (MDS-UPDRS) Part 2: Measures ability to do everyday activities (teeth brushing, dressing on your own, etc.) Part 3: Measures ability to do walk, stand, balance Improvement occurs when numbers
decrease; Worsening occurs when numbers increase Mean Changes From Baseline 1 End of Study 50 mg 100 mg 200 mg Placebo N=3 N=2 N=3 N=3 MDS-UPDRS -0.33 0 -4.33 0 Part 2 MDS-UPDRS 2 -1.3 -4.33 1.7 Part 3 Part 2 + Part 3 1.67 -1.3 -8.7 1.7 -10.4 1
Given small sample size, we do not yet conclude that a clinical benefit has been achieved. Inhibikase.com : IKT 14
THE 201 TRIAL; BIOMARKER ANALYSIS ONGOING Blood and CSF biomarkers
Tissue-derived biomarkers Tissue biomarkers may indicate clearance of plaque Spinal fluid biomarkers may confirm proper diagnosis of pathology in the 201 Trial. Proprietary antibody against disease in the 201 Trial. phosphorylated alpha-synuclein
will use this method to report on target engagement as well. Inhibikase.com : IKT 15
INHIBITION OF C-Abl MAY HAVE A WIDER ROLE IN OTHER DISEASES
Risvodetinib in other neurodegenerative disease 1 MSA ALS Alzheimer's J Neurol Sci. 2018;393:80-82 Prog Neurobiol. 2021;202:102031 Autophagy. 2021;17(5):1278-1280. Sci Transl Med. 2017;9(391):eaaf3962 J Biol Chem. 2020 ;295(23):7905-7922 Front
Cell Neurosci. 2015 9;9:203 Front Cell Neurosci. 2019;13:526 PLoS One. 2012;7(9):e46185 Biochim Biophys Acta Mol Basis Dis. 2018; 1864(4 Pt A):1148-1159 Biomol Struct Dyn. 2017;35(4):883-896 J Alzheimers Dis. 2016 ;54(3):1193-1205 PLoS One. 2014
;9(3):e92309 Curr Alzheimer Res. 2011;8(6):643-51. Neurobiol Aging. 2011;32(7):1249-61. J Alzheimers Dis. 2011;25(1):119-33. J Alzheimers Dis. 2010;19(2):721-33. J Alzheimers Dis. 2009;18(1):1-9 J Alzheimers Dis. 2009;17(2):409-22 Brain. 2008;131(Pt
9):2425-42 Neurobiol Dis. 2004;17(2):326-36 Proc Natl Acad Sci U S A. 2003;100(21):12444-9. 1 Marmion, Werner, Kordower et al, (2021) Neurobiol Dis 148:105184 Inhibikase.com : IKT 16
IkT-001Pro for Treatment of Blood and Stomach Cancers and
Cardiopulmonary Disease Inhibikase.com : IKT 17
IkT- 001Pro INNOVATION IkT-001Pro releases the active ingredient
imatinib only in blood 4-carbon atom linker imatinib linker gut wall + pH 2-6 pH 7 (blood) (stomach, ileum, duodenum) Lifetime in blood < 10 min Inhibikase.com : IKT 18
IkT- 001Pro IS A SMALL MOLECULE C-Abl INHIBITOR IkT-001Pro has less
toxicity in non-human primate: Potentially Safer Alternative to Imatinib Mesylate Measurement of IkT-001Pro in Non-Human Primates RESULTS SUGGEST THAT: No Adverse Event Level Cmax Tmax AUC 0-T (mg/kg) Achieve dose flexibility, (mean, ng/mL)
(mean, h) (mean, ng-h/mL) NOAEL including use of higher dosing due to lower AEs Imatinib 176/206 4/3 1540/1960 15 1 (Day 91) (M/F) (M/F) (M/F) Suppress GI and other adherence-related adverse 2 IkT-001Pro 400/318 5.3/3.7 5220/3890 75 events
(Day 28) (M/F) (M/F) (M/F) 1 FDA summary data for approval 21-335 2 IkT IND #135167 NO ADVERSE EVENTS Up to 3.4x Up to 3.4x increased exposure higher dose of imatinib delivered as 001Pro Inhibikase.com : IKT 19
TRIALS IN BIOEQUIVALENCE AND SUPERIORITY Clinical Development of
IkT-001Pro: Summary Phase 3 Complete in Blood and Stomach Cancers Competes against generic imatinib mesylate 1 $300M market US Phase 2/3 Ready in Pulmonary Arterial Hypertension Proven to be
disease-modifying, but Phase 3 needs to be repeated due to 2 safety concerns 10 years ago Developing to compete with sotatercept, marketed as Winrevair (approved March, 2024) 3 4 4 $4.6B market US , $7B+ global, 5.3% CAGR 1 ISI retail
sales data 2016-2020 2 Circulation 2013;127:1128-1138 3 From Biomedtracker (Citeline Commercial), 2024 (https://www.biomedtracker.com/indicationreport.cfm?indid=245#PipelineChart) 4 Precedence Research, 2023
(https://www.linkedin.com/pulse/pulmonary-arterial-hypertension-market-prathamesh-sakpal-lvrfc/) Inhibikase.com : IKT 20
Selected Financial Data IIn nh hib ibik ika as se e..c co om m
COMPANY HIGHLIGHTS Selected Financial and Stock Data Capitalization
Table April 15, 2024 Balance Sheet December 31, 2023 Common Shares Outstanding 6,476,844 Current Assets: Options (WAEP: $10.33) 985,280 Cash, Cash Equivalents, Warrants (WAEP: $7.64) 2,266,136 $13,252,052 Marketable Securities Prepaid research and
Fully Diluted Shares Outstanding 9,728,260 $219,817 development Prepaid expenses and other $739,179 current assets Total Current Assets $14,211,048 Total Current Liabilities $3,438,601 Total Working Capital $10,772,447 Inhibikase.com : IKT
ABOUT US / EXECUTIVES Management Team with Deep Experience in Drug
Development and Commercialization Milton Werner, PhD Garth Lees-Rolfe C. Warren Olanow, MD, President & CEO Chief Financial Officer Medical Consultant and Chief Executive Officer of Clintrex Research Corporation. Previously, Dr. Werner served as
Director of Previously served as our Vice Research at Celtaxsys. From September 1996 until President of Finance from Dr. Olanow is the former Henry P. and Georgette Goldschmidt Professor and Chairman of June 2007, Dr. Werner was a Head of the
November 2022 to March 2024. the Department of Neurology at the Mount Sinai School of Medicine Prior to joining Mount Laboratory of Molecular Biophysics at The Prior to Inhibikase served as the Sinai, he served on the faculties of McGill University,
Duke University, and the University of Rockefeller University in New York City. Throughout Vice-President, Finance for F- South Florida. He is the former President of the Movement Disorder Society, past President of the International Society of
Motor Disturbances, and former Treasurer of the American his scientific career, Dr. Werner has been an Star, Inc., a publicly traded global Neurological Association. He has served on the executive committee of the Michael J. Fox innovator
integrating chemistry, physics, and biology clinical-stage biotech company. Foundation Scientific Advisory Board, and he is the former Chairman of the Scientific into a comprehensive approach to solving problems Prior to his corporate work, spent 16
Advisory Board of the Bachmann-Strauss Parkinson Foundation and of the Dystonia in medicine. Dr. Werner is the author or co-author of years in public practice mostly with Foundation. Dr. Olanow is the former Co-Editor-in-Chief of the journal
Movement Disorders. more than 70 research articles, reviews, and book Ernst & Young, lastly as a Senior Dr. Olanow received his medical degree from the University of Toronto, performed his chapters and has given lectures on his research Manager.
He is a licensed Certified neurology training at the New York Neurological Institute at Columbia Presbyterian Medical work throughout the world. Public Accountant in the state of Center at Columbia University, and undertook postgraduate studies in
neuroanatomy at Massachusetts and a licensed Columbia University and authored more than 600 articles in the field of neurodegeneration. Chartered Accountant of Australia and New Zealand. Inhibikase.com : IKT 23