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BOSTON, Oct. 01, 2021 (GLOBE NEWSWIRE) -- Ikena Oncology, Inc. (Nasdaq: IKNA), a targeted oncology company navigating new territory in patient-directed cancer treatment, today announced that three abstracts highlighting the company’s Aryl Hydrocarbon Receptor (AHR) antagonist program, with novel inhibitor IK-175, will be presented at the SITC 2021 Annual Meeting. IK-175 is an oral AHR antagonist designed to modulate the tumor microenvironment to increase both innate and adaptive immunity and is currently being studied in a Phase 1 clinical trial.
Society for Immunotherapy of Cancer (SITC) 36th Annual Meeting & Pre-Conference Programs (SITC 2021) is being held in-person and virtually November 10-14, 2021. Abstract details can be found below.
Aryl Hydrocarbon Receptor (AHR) Antagonist Program
Title: A Phase 1a/b Study of IK-175, an Oral AHR Inhibitor, Alone and in Combination with Nivolumab in Patients with Locally Advanced or Metastatic Solid Tumors and Urothelial Carcinoma
Abstract Number: 392
Presenter: Jason Luke MD, FACP, Trial Investigator, UPMC Hillman Cancer Center
Title: Computational biology and tissue-based approaches to inform indication selection for a novel AHR inhibitor
Presenter: Marta Sanchez-Martin, PhD, Ikena Oncology
Title: Analytical validation of a novel immunohistochemistry assay to determine nuclear AHR expression in human bladder cancer
Presenter: Lei Wang, PhD, Ikena Oncology
The Phase 1 trial of IK-175 is currently recruiting in both monotherapy and combination arm in advanced solid tumors and recently expanded its monotherapy urothelial carcinoma cohort. For more information on the Society for Immunotherapy of Cancer (SITC) 36th Annual Meeting and how to register, visit the website.
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