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IDEAYA Biosciences Announces Late-Breaker Oral Presentation of IDE397 Phase 1 Expansion Results in MTAP-Deletion Lung and Urothelial Cancer at the 36th Edition of the EORTC-NCI-AACR Symposium IDEAYA Biosciences, Inc. (Nasdaq:IDYA), a precision medicine oncology company committed to the discovery and development of targeted therapeutics,...

Key Takeaway: IDEAYA Biosciences announced a late-breaking oral presentation of IDE397 Phase 1 expansion results targeting MTAP-deletion lung and urothelial cancer. The presentation will occur at the EORTC-NCI-AACR Symposium in Barcelona on October 25, 2024. Additionally, IDEAYA will showcase preclinical data for its MAT2A and PARG programs during the event.
Price reaction · baseline $29.25 (2024-10-03 close) · hit after-hours · clean, no other IDYA news in the window
day 0 close · peak
+2.5%

Market Sentiment Analysis

POSITIVE FACTORS

  • IDE397 shows promising results in treating MTAP-deletion cancers.
  • The presentation at a major symposium highlights IDEAYA's innovative approach.
  • The company is advancing its pipeline with additional poster presentations.

BiopharmaWatch Analysis

From our catalyst data and publicly available data · not financial advice
Best trade, last catalyst
+47%
120-day peak, hindsight
Typical move
5.2%
average across 6 past catalysts
Cash runway
~42 mo
Minimal dilution risk
Lead asset
IDE892
Phase 1 · NSCLC Adenocarcinoma

Full Press Release Details

SOUTH SAN FRANCISCO, Calif. , Oct. 4, 2024 /PRNewswire/ -- IDEAYA Biosciences, Inc. (Nasdaq: IDYA ), a precision medicine oncology company committed to the discovery and development of targeted therapeutics, announced a late-breaking oral presentation of the Phase 1 expansion results of IDE397, a first-in-class, oral, MAT2A inhibitor in methylthioadenosine phosphorylase (MTAP)-deletion urothelial and non-small cell lung cancer (NSCLC) patients at the 36th edition of the EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics taking place on October 23 to 25, 2024 , in Barcelona , Spain. In addition, IDEAYA will also have additional poster presentations at the EORTC-NCI-AACR Symposium highlighting preclinical data for the MAT2A and PARG programs.
Details for the oral presentation are as follows: Presenter: Dr. Benjamin Herzberg, MD, Assistant Professor, Columbia University Title: Phase 1 expansion results of IDE397, a first-in-class, oral, MAT2A inhibitor (MAT2Ai) in MTAP deleted(del) non-small cell lung cancer (NSCLC) and urothelial cancer (UC) Abstract #: 501 LBA Session: Plenary Session 7, Late Breaking Abstracts and Proffered Papers: Novel discoveries in drug development Date and Time: Friday, October 25, 2024 at 3:00pm CEST
Poster presentation details are below: Author: Garbett, D. et al. Title: The mechanistic basis of both deep and durable antitumor activity by combinatorial inhibition of MAT2A and PRMT5 in MTAP-deleted tumors Poster Number: PB204 Session Title: Combination Therapies Date and Time: Thursday, October 24, 2024 , 9:00am - 5:30pm CEST , Exhibition Hall
Author: Munoz, D. et al. Title: IDE161, a potential first-in-class clinical candidate PARG inhibitor, selectively targets solid tumors with replication stress and DNA repair vulnerabilities Poster Number: PB337 Session Title: DNA Repair Modulation (e.g. PARP, CHK, ATR, ATM) Date and Time: Friday, October 25, 2024, 9:00am - 3:00pm CEST , Exhibition Hall
The oral presentation and posters will be available online at https://ir.ideayabio.com/events following the presentations.
About IDEAYA Biosciences IDEAYA is a precision medicine oncology company committed to the discovery and development of targeted therapeutics for patient populations selected using molecular diagnostics. IDEAYA's approach integrates capabilities in identifying and validating translational biomarkers with drug discovery to select patient populations most likely to benefit from its targeted therapies. IDEAYA is applying its research and drug discovery capabilities to synthetic lethality – which represents an emerging class of precision medicine targets.
Forward-Looking Statements This press release contains forward-looking statements, including, but not limited to, statements related to the timing and content of future presentations. Such forward-looking statements involve substantial risks and uncertainties that could cause IDEAYA's preclinical and clinical development programs, future results, performance or achievements to differ significantly from those expressed or implied by the forward-looking statements. Such risks and uncertainties include, among others, the uncertainties inherent in the drug development process, including IDEAYA's programs' early stage of development, the process of designing and conducting preclinical and clinical trials, the regulatory approval processes, the timing of regulatory filings, the challenges associated with manufacturing drug products, IDEAYA's ability to successfully establish, protect and defend its intellectual property, and other matters that could affect the sufficiency of existing cash to fund operations. IDEAYA undertakes no obligation to update or revise any forward-looking statements. For a further description of the risks and uncertainties that could cause actual results to differ from those expressed in these forward-looking statements, as well as risks relating to the business of IDEAYA in general, see IDEAYA's Annual Report on Form 10-K dated February 20, 2024 and any current and periodic reports filed with the U.S. Securities and Exchange Commission.
Investor and Media Contact IDEAYA Biosciences Andres Ruiz Briseno SVP, Head of Finance and Investor Relations [email protected]

Frequently Asked Questions

What is IDE397?

IDE397 is a first-in-class oral MAT2A inhibitor targeting MTAP-deletion cancers.

When will the IDE397 results be presented?

The results will be presented on October 25, 2024, at the EORTC-NCI-AACR Symposium.

Who will present the IDE397 findings?

Dr. Benjamin Herzberg from Columbia University will present the findings.

What other presentations will IDEAYA have?

IDEAYA will also present preclinical data on MAT2A and PARG programs.

Last updated: Oct 4, 2024