European Study Provides More Evidence Supporting IceCure's ProSense is Safe & Effective Cryoablation Treatment for Metastatic and Recurrent Breast Cancer Independent, third-party data published in highly influential peer

European Study Provides More Evidence Supporting

IceCure's ProSense is Safe & Effective Cryoablation Treatment for Metastatic and Recurrent Breast Cancer

CAESAREA, Israel, July 9, 2024 -

IceCure Medical Ltd. (Nasdaq: ICCM) ("IceCure", "IceCure Medical" or the "Company"), developer of

minimally-invasive cryoablation technology that destroys tumors by freezing as an alternative to surgical tumor removal, today announced

the publication of an independent study evaluating its flagship cryoablation system ProSense titled: "CT-Guided Percutaneous

Cryoablation of Breast Cancer: A Single-Center Experience" in Cancers, a leading peer-reviewed oncology journal. The study,

led by Principal Investigator Professor Thomas J. Vogl, was conducted at the Institute of Radiology and Nuclear Medicine, University

Hospital Frankfurt, at Goethe University, Germany.

Professor Vogl commented, "Liquid Nitrogen-based

cryoablation was found to be a safe local treatment for breast cancer, with a low complication rate-in fact, none were observed

in the study. We experienced a very high complete ablation rate of 100%. Overall survival, progression free survival and local tumor control

were all good, especially given the very heterogenous patient population. The fact that this is a minimally invasive procedure that can

be performed on an outpatient basis with excellent cosmetic results are clear advantages. We look forward to further evaluations of cryoablation

especially in comparison to other treatment modalities for early, recurrent, and metastatic breast cancer."

"While this study's patient population

is very different from our U.S. based ICE3 study and the target indication for which we have filed for regulatory approval in the U.S.,

the results of the study are highly valuable for ProSense users in Europe where our system is approved for general breast cancer

treatment. This higher risk patient population included patients with metastatic disease and tumors of up to 4 centimeters in diameter,

as compared to our ICE3 study population with early-stage disease and tumors smaller than 2 centimeters in diameter, indicating a very

different recurrence rate. Importantly, it further informs and supports the use cases of ProSense across a broader range of breast

cancer diagnoses, from newly diagnosed early-stage to metastatic and recurrent disease," stated IceCure CEO Eyal Shamir. "We

thank Dr. Vogl, his team, and University Hospital Frankfurt for their initiative in conducting this study and expanding the body of knowledge

for the cryoablation of breast cancer."

This independent study, which received no financial

support from IceCure, retrospectively evaluated the efficacy and safety of liquid-nitrogen based CT-guided cryoablation with ProSense .

Patients were treated in out-patient settings with curative intention for non-metastatic patients, while patients with metastases were

treated to achieve local tumor control. The patient population (n=45, with 56 tumors) with a mean age of 55.6 12.5 years (range,

31.3-86.0 years) was very heterogeneous and different from IceCure's ICE3 study population and included 11 patients with recurrent

tumors and 21 patients with metastatic disease. Patients were observed at three, six, nine, and 12 months, respectively, and after the

first year were followed up biannually. There were four cases of local tumor progression, representing a rate of 8.9%. There were no complications

observed in any of the 56 ablations and initial complete ablation was achieved in 100% of cases.

The ProSense Cryoablation System provides

a minimally invasive treatment option to destroy tumors by freezing them. The system uniquely harnesses the power of liquid nitrogen to

create large lethal zones for maximum efficacy in tumor destruction in benign and cancerous lesions, including breast, kidney, lung, and

ProSense enhances patient and provider value

by accelerating recovery, reducing pain, surgical risks, and complications. With its easy, transportable design and liquid nitrogen utilization,

ProSense opens that door to fast and convenient office-based procedure for breast tumors.

About IceCure Medical

IceCure Medical (Nasdaq: ICCM) develops and markets

advanced liquid-nitrogen-based cryoablation therapy systems for the treatment of tumors (benign and cancerous) by freezing, with the primary

focus areas being breast, kidney, bone and lung cancer. Its minimally invasive technology is a safe and effective alternative to hospital

surgical tumor removal that is easily performed in a relatively short procedure. The Company's flagship ProSense system is marketed

and sold worldwide for the indications cleared and approved to date including in the U.S., Europe and China.

Forward Looking Statements

This press release contains forward-looking statements

within the meaning of the "safe harbor" provisions of the Private Securities Litigation Reform Act of 1995 and other Federal

securities laws. Words such as "expects," "anticipates," "intends," "plans," "believes,"

"seeks," "estimates" and similar expressions or variations of such words are intended to identify forward-looking

statements. For example, IceCure is using forward looking statements in this press release when it discusses: further evaluations of cryoablation,

especially in comparison to other treatment modalities for early, recurrent and metastatic breast cancer. Historical results of scientific

research and clinical and preclinical trials do not guarantee that the conclusions of future research or trials will suggest identical

or even similar conclusions. Important factors that could cause actual results, developments and business decisions to differ materially

from those anticipated in these forward-looking statements include, among others: the Company's planned level of revenues and capital

expenditures; the Company's available cash and its ability to obtain additional funding; the Company's ability to market and sell its

products; legal and regulatory developments in the United States and other countries; the Company's ability to maintain its relationships

with suppliers, distributors and other partners; the Company's ability to maintain or protect the validity of its patents and other intellectual

property; the Company's ability to expose and educate medical professionals about its products; political, economic and military instability

in the Middle East, specifically in Israel; as well as those factors set forth in the Risk Factors section of the Company's Annual Report

on Form 20-F for the year ended December 31, 2023 filed with the SEC on April 3, 2024, and other documents filed with or furnished to

the SEC which are available on the SEC's website, www.sec.gov. The Company undertakes no obligation to update these statements for revisions

or changes after the date of this release, except as required by law.

Email: investors@icecure-medical.com