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IMMUNOPRECISE ANTIBODIES LTD.
MANAGEMENT DISCUSSION AND ANALYSIS
FOR THE THREE AND NINE MONTHS ENDED JANUARY 31, 2025
The following Management's Discussion and Analysis ( MD&A ) should be read in conjunction with the unaudited condensed interim consolidated financial statements of ImmunoPrecise Antibodies Ltd. ( the Company , ImmunoPrecise or IPA ) for the three and nine months ended January 31, 2025, together with the audited consolidated financial statements and accompanying MD&A of the Company for the year ended April 30, 2024. This MD&A is the responsibility of management and was reviewed and approved by the Board of Directors of IPA (the Board ) on March 27, 2025.
The referenced financial statements have been prepared in accordance with International Financial Reporting Standards ( IFRS ), as issued by the International Accounting Standards Board ( IASB ) and as applicable to the preparation of interim financial statements, including IAS 34, Interim Financial Reporting. Except as otherwise noted, all dollar figures in this MD&A are stated in Canadian dollars, which is the Company's reporting currency.
We have prepared this MD&A with reference to National Instrument 51-102 Continuous Disclosure Obligations of the Canadian Securities Administrators. Additional information relating to ImmunoPrecise, including our most recently completed Annual Information Form and our Annual Report on Form 20-F for the fiscal year ended April 30, 2024, is available on our website at www.ipatherapeutics.com and can be found on SEDAR+ at www.sedarplus.ca and EDGAR at www.sec.gov/edgar.
FORWARD-LOOKING INFORMATION
This MD&A contains certain statements that constitute forward-looking statements within the meaning of National Instrument 51-102 - Continuous Disclosure Obligations of the Canadian Securities Administrators.
Forward-looking statements often, but not always, are identified by the use of words such as seek , anticipate , believe , plan , estimate , expect , targeting and intend and statements that an event or result may , will , should , could , or might occur or be achieved and other similar expressions.
This document contains forward-looking statements about IPA's future outlook, future plans and expenditures, the satisfaction of rights and performance of obligations under agreements to which IPA is a party, product development, future revenue growth, research and development ( R&D ) initiatives, and general market trends and developments. These statements, which involve expectations, estimates, and projections, are not guarantees of future performance and involve risks and uncertainties that are difficult to predict and/or are beyond IPA's control.
The forward-looking statements are based on certain assumptions, including the progress, timing, and costs related to the execution of IPA's business plan and strategy; estimates and projections regarding the industry in which IPA operates; the future success of R&D activities, including the advancement of IPA's AI technologies, the LENSai software, and HYFTTM technology. Assumptions are also made on the absence of material changes in various areas such as regulatory environment, general business and economic conditions, market demand for IPA's services, competitive landscape, and technological disruptions. Furthermore, the statements take into account estimates regarding future financing and capital.
The success of IPA's AI technologies is subject to inherent uncertainties of technology development and implementation, including the complexity of tasks the AI is being developed to perform, potential technical difficulties, the necessity for continuous adaptation to new scientific findings and data, and regulatory and ethical considerations. Furthermore, the potential for IPA's AI technologies to generate revenues is contingent upon market acceptance, development of commercially viable applications, and establishment of successful business models.
Forward-looking statements inherently carry risks and uncertainties that could cause actual outcomes and results to differ materially from current expectations. Thus, these statements should be approached with caution, and undue reliance on them should be avoided. Some of these risks and uncertainties are outlined in the Risks and Uncertainties section of this MD&A. It is important to note that
IMMUNOPRECISE ANTIBODIES LTD.
MANAGEMENT DISCUSSION AND ANALYSIS
FOR THE THREE AND NINE MONTHS ENDED JANUARY 31, 2025
forward-looking statements are not assurances of future performance. As actual results and future events could vary significantly from those anticipated in these statements, they should not be taken as accurate predictions. Despite the potential updates or revisions of forward-looking statements due to new information or future events, IPA is under no obligation to make these changes unless required by law. These cautionary notes serve to qualify all forward-looking statements contained in this MD&A explicitly.
CAUTION REGARDING NON-IFRS MEASURES
In addition to the results reported in accordance with IFRS, this MD&A makes reference to certain measures that are not recognized under IFRS and do not have a standardized meaning prescribed by IFRS. They are therefore unlikely to be comparable to similar measures presented by other companies. The Company uses non-IFRS measures, including adjusted EBITDA as additional information to complement IFRS measures by providing further understanding of the Company's results of operations from management's perspective. Management believes that these measures provide useful information in that they may exclude amounts that are not indicative of the Company's core operating results and ongoing operations and provide a more consistent basis for comparison between periods. For further details, please refer to the Non-IFRS Measures section in this MD&A.
Founded on November 22, 1983, and incorporated under Alberta law, IPA's common shares ( Common Shares ) currently trade on the Nasdaq Capital Market under the ticker symbol IPA . The corporate headquarters of IPA is situated at Industrious 823 Congress Ave Suite 300 Austin, Texas 78701.
The Company is a leading biotherapeutic research and technology firm, distinguished by its proficiency in both in silico and wet lab methodologies. At the intersection of systems biology, multi-omics modeling, and complex artificial intelligence systems, the Company has carved out a unique space within the field. The core of the Company's operations encompasses a diverse suite of proprietary technologies that aid in the exploration, discovery, and development of novel drugs and biologics.
Integrated within IPA's wet lab infrastructure is a diverse array of in silico technologies. As an end-to-end service provider of antibody discovery and development, IPA's state-of-the-art computational methodologies allow the Company to perform detailed and comprehensive evaluations across various stages of biologic discovery and development.
The synergy between IPA's in silico analyses and wet lab technologies enhances the efficacy of the workflow, thereby offering a unique value proposition to its partners aimed at reducing the time, cost and risk associated with therapeutic antibody discovery and development. This strategic integration underscores IPA's commitment to innovative solutions, driving not only operational efficiency but also pioneering advancements in the industry.
The Company believes that its experience, innovation, technologies, scientific rigor, and focus on producing quality products, provide a unique experience in one-stop service offerings, and assist the Company in its aim to reduce the time required for, and the inherent risk associated with, conventional multi-vendor product development.
The Company has achieved organic revenue growth through market penetration and service diversification in the biologics, Contract Research Organizations ( CRO ) space, as well as accretive growth through strategic expansion of its operations in Europe, by acquiring and integrating innovative technologies, and through investments in R&D.
IMMUNOPRECISE ANTIBODIES LTD.
MANAGEMENT DISCUSSION AND ANALYSIS
FOR THE THREE AND NINE MONTHS ENDED JANUARY 31, 2025
The breadth of services provided by IPA unfolds sequentially in alignment with the process of antibody discovery and development. Starting from the in silico arena, the Company utilizes custom antigen modeling, target analysis using Natural Language Processing, and the patented HYFTTM analysis to lay the groundwork for the subsequent experimental phases.
As the projects transition into the wet lab phase, the Company's capabilities diversify, offering an array of services such as design and manufacturing, B cell sorting incorporating IPA's proprietary Function First B Cell screening and sequencing, and the production and screening of custom, immune, and proprietary na ve phage display libraries. IPA's wet lab antibody discovery technologies are compatible with in-depth mining of antibody repertoires by next generation sequencing and computational analysis. The Company's hybridoma discovery and production services, enhanced by multiplexed high-throughput screening and single clone-picking, complement the expertise it possesses with transgenic animals and multi-species antibody discovery.
The Company then steps into antibody characterization studies, which encompass affinity measurements, epitope landscape profiling, functional assays, and in silico analyses including immunogenicity, three-dimensional modeling, relative affinity rankings, molecular docking, and off-target analyses. Additional services include the creation of bi-specifics, single domain (such as VHH and VNAR (shark)) antibodies, recombinant cloning, protein and antibody production and downstream processing, stable cell line generation, antibody engineering, optimization including humanization, and cryopreservation and cryostorage.
ImmunoPrecise's wholly owned subsidiaries, IPA Canada and IPA Europe, have received recognition as approved CRO for top-tier transgenic animal platforms producing antibodies with human antigen binding domains, along with protein manufacturing. The subsidiaries also form a critical component of the Company's R&D investments, promoting the development of proprietary technologies like B cell Select and DeepDisplayTM platforms, applicable across a wide array of species and strains, including transgenic animals.
Moreover, in the past two years, the Company has gained increasing recognition as a rising leader in the biologics CRO space, with a focus on organic growth through market penetration and service diversification, as well as strategic expansion with platform and process integration. Furthermore, end-to-end services have been leveraged through acquisition, enabling a steady foundation for future growth.
Operations of the Company
IPA is a global operation with a presence in Utrecht and Oss in the Netherlands, Diepenbeek in Belgium, Victoria, British Columbia, in Canada, Fargo, North Dakota and Austin, Texas in the United States. This broad reach enables IPA to tap into thriving locations that strongly support the life sciences industry and the development of AI.
The Company's leadership, spanning North America and Europe, holds global responsibility for financial and accounting oversight, sales and marketing, investor relations, and information technology. An enterprise resource management system aids in automating marketing and sales, enhancing customer relationship management, and simplifying accounting, financial reporting, and project management tasks.
The Company's head office is in Austin, Texas, and the base for U.S. operations is in Fargo, North Dakota. IPA Canada operates from Victoria, British Columbia, performing custom antibody generation since its inception. The Company has recently completed the expansion of its vivarium in Victoria while simultaneously intensifying its capabilities in measuring protein binding kinetics and high-throughput label-free protein-protein interactions and further developing and improving technologies such as its B cell Select platform.
The acquisition of U-Protein Express B.V. ( UPE ) and ModiQuest Research B.V. ( MQR ), now collectively named IPA Europe, has deepened the Company's technological competence, and expanded its capabilities for partners worldwide. The team from MQR in Oss brings extensive expertise in various areas, including in vitro antibody phage library generation, antibody characterization, optimization,
IMMUNOPRECISE ANTIBODIES LTD.
MANAGEMENT DISCUSSION AND ANALYSIS
FOR THE THREE AND NINE MONTHS ENDED JANUARY 31, 2025
and engineering. The UPE team in Utrecht specializes in the production of complex proteins and antibodies, supporting numerous programs across various sectors using their proprietary expression platform rPEx .
On April 14, 2022, the Company successfully acquired BioStrand BV, BioKey BV, and BioClue BV, a group of innovative AI entities based in Belgium. These entities are leaders in the field of multi-omics and in silico biotechnology, specializing in the intricate task of identifying unique biological fingerprints within proteins, RNA, and DNA across multiple information layers, giving rise to unprecedented insights into biological molecules, including intricate relationships between protein structure and function. They have constructed a comprehensive knowledge base of these distinctive biological markers, which serves as a significant tool for their comparison and processing. This strategic acquisition further bolsters the Company's standing in the rapidly advancing fields of multi-omics and in silico antibody discovery and development.
The Company continues to broaden its intellectual property portfolio in additional, meaningful ways, including internal R&D, acquisitions, and collaborations. There is also an emphasis on therapeutic antibody asset development in areas such as oncology, inflammation, neurodegenerative diseases, autoimmunity, and atherosclerosis.
STRATEGY AND OUTLOOK
The management team at IPA places a strong emphasis on initiatives designed to increase revenue, enhance internal assets, and maximize shareholder value. Central to the Company's mission is the aspiration to fundamentally transform the approach to biotherapeutic discovery and development. By integrating its advanced AI-driven software, LENSai, IPA aims to introduce a new paradigm that underscores accuracy, precision, speed, and cost-effectiveness, thereby changing how the world processes complex and disparate data.
One core component of IPA's strategy is the integration of LENSai's in silico capabilities into its services. LENSai adds high-through-put in silico analytical capabilities early in the discovery and development cycle, which enhances the Company's traditional wet lab services.
IPA's goal is to be the world's premier partner for complex AI-driven therapeutic antibody discovery and development, providing a rapid, integrated, accurate, data-driven, technologically advanced continuum of services. The Company works towards accelerating the transition of novel therapies from idea to the clinic by providing a bridge between highly accurate in silico predictions and wet lab validations. IPA's in silico tools, powered by LENSai, can predict potential targets, antibody binding characteristics, therapeutic developability, safety and tolerability, functional outcomes, and provide iterative feedback from wet lab experiments designed to refine these predictions and improve the accuracy of its AI models.
In 2022, to accommodate operational growth, IPA relocated its Utrecht facility to larger premises within the Utrecht Science Park, which resulted in a doubling of the site's lab capacity. This strategic move was driven by the need to meet increasing market demands in Europe, North America, and Asia.
Pharmaceutical industry trends suggest an increasing reliance on external partners like IPA for expertise, cost-effectiveness, and rapid turnaround times. As a service provider with both wet lab and AI-driven in silico capabilities, management believes the Company aligns well with these industry needs.
The monoclonal antibody market is experiencing sustained growth, with an increasing focus on antibody R&D in response to the rising incidence of cancer, infectious diseases, and chronic diseases. The therapeutic antibody market, valued at U.S.$115 billion in 2018 according to a study published in the Journal of Biomedical Science in January 2022, is projected to reach U.S.$300 billion by 2025. According to GrandViewResearch.com, the protein and antibody-related service and product market is predicted to grow at a CAGR of 6.2% to U.S.$5.6 billion by 2027.
IMMUNOPRECISE ANTIBODIES LTD.
MANAGEMENT DISCUSSION AND ANALYSIS
FOR THE THREE AND NINE MONTHS ENDED JANUARY 31, 2025
IPA is not simply adapting to market trends but is attempting to actively set new standards and demonstrate novel capabilities. The Company considers itself a leader in the field of AI-integrated biotherapeutics research. The Company's unique blend of AI-driven in silico capabilities and traditional wet lab services guides its innovation.
AI for Drug Discovery
The initial stage of the drug discovery process involves identifying a therapeutic target followed by the discovery of novel drug candidates. These phases involve leveraging AI to speed up the process of identifying and selecting new antibodies. The LENSai platform employs machine learning and other AI methodologies to analyze vast amounts of data related to antibodies, yielding insights into their structure, function, and intermolecular interactions. Potential drug candidates are evaluated based on parameters such as efficacy, potency, bioavailability, and toxicity.
AI is increasingly becoming a crucial tool in the healthcare industry, especially in the area of drug research. AI technology has the capability to identify therapeutic targets and plays a critical role in the design, discovery, and efficient screening of molecules. According to a 2022 report by ReportLinker, the AI Drug Discovery Market, valued at U.S.$253.8 million in 2019, is projected to reach U.S.$3.9 billion by 2030, growing at a CAGR of 40.8 % from 2020 to 2030. This anticipated growth is attributed to the ability of AI to understand disease mechanisms, establish biomarkers, and generate data or models for the drug discovery process.
The acquisition of BioStrand in April 2022 marked a significant advancement for the Company. BioStrand brings its unique and proprietary HYFT technology that adds accuracy and transparency (explainability) to traditional AI approaches and algorithms, an extremely important feature, especially in the life sciences.
The Company's AI-driven software, LENSai, takes advantage of this technology. It enables the Company to extract the potential from data, discover connections between data, and pull new and valuable information from existing data. Furthermore, BioStrand's HYFT framework converts unstructured data into structured data, allowing for default feature reduction and efficient downstream analysis using advanced AI/ML techniques. The HYFT fingerprints create a link between sequences and literature analysis through a bottom-up Natural Language Processing approach, providing a universal syntax for the language of biology. This proprietary pattern and profile detection is crucial for understanding diseases and biological processes.
BioStrand's HYFT framework makes all accessible biological data rapidly computable. The technology developed by BioStrand offers a solution for omics (DNA, RNA, amino acids) data management, analysis, and storage, effectively addressing the current challenges and bottlenecks in bioinformatics. The integration of this technology with the LENSai platform results in an incredibly efficient system for managing and analyzing omics data. This combination of technologies is capable of processing huge tasks at high speed and scale, all while maintaining a light computational footprint.
OVERALL PERFORMANCE AND LIQUIDITY
The Company achieved revenues of $6.2 million and $17.5 million during the three and nine months ended January 31, 2025, a 1.1% and 2.9% decrease from 2024 revenues of $6.2 million and $18.1 million, respectively. The Company incurred cost of sales of $2.9 million and $8.5 million during the three and nine months ended January 31, 2025, a $0.1 and $0.7 million decrease for the three and nine months ended January 31, 2024 cost of sales, respectively. The Company incurred total operating expenses of $27.8 million during the three months ended January 31, 2025, an increase of $21.2 million compared to the three months ended January 31, 2024. Operating expenses totaled $41.2 million during the nine months ended January 31, 2025, an increase of $22.0 million compared to the nine months ended January 31, 2024. Net loss totaled $21.5 million and $28.1 million for the three and nine months ended January 31, 2025, compared to a net loss of $2.7 million and $8.5 million during the same periods last year. Operating expense and net loss increased due to a $21.2 million impairment loss on the intangible assets of BioStrand during the three months ended January 31, 2025.
As of January 31, 2025, the Company had cash on hand of $12.9 million compared to $3.5 million as of April 30, 2024. The Company expects its cash on hand as of January 31, 2025 will be insufficient to fund the Company's operations for at least one year from the date
IMMUNOPRECISE ANTIBODIES LTD.
MANAGEMENT DISCUSSION AND ANALYSIS
FOR THE THREE AND NINE MONTHS ENDED JANUARY 31, 2025
these financial statements are available to be issued. These conditions raise material uncertainties which cast significant doubt as to whether the Company will be able to continue as a going concern should it not be able to obtain financing necessary to fund its planned revenue growth and working capital requirements.
The Company will need to raise additional funds to finance its operations and strategic goals and there can be no assurances that sufficient funding, including adequate financing, will be available. The ability of the Company to arrange additional financing in the future depends in part on the prevailing capital market conditions and profitability of its operations. If the Company is unable to raise sufficient funds, reductions in expenditures will be required, and this may impact the future growth plans of the Company.
IMMUNOPRECISE ANTIBODIES LTD.
MANAGEMENT DISCUSSION AND ANALYSIS
FOR THE THREE AND NINE MONTHS ENDED JANUARY 31, 2025
RESULTS OF OPERATIONS
Comparison of the three months ended January 31, 2025 and 2024
| Three Months Ended January 31, | ||||||||||||||||
| (in thousands) | 2025 $ | 2024 $ | Change $ | Change % | ||||||||||||
| Project revenue | 5,572 | 5,774 | (202 | ) | -3.5 | % | ||||||||||
| Product sales revenue | 501 | 395 | 106 | 26.8 | % | |||||||||||
| Cryostorage revenue | 78 | 52 | 26 | 50.0 | % | |||||||||||
| Total revenue | 6,151 | 6,221 | (70 | ) | -1.1 | % |
The Company achieved revenue of $6.2 million during the three months ended January 31, 2025, a 1.1% decrease from the three months ended January 31, 2024.
| Three Months Ended January 31, | ||||||||||||||||
| (in thousands) | 2025 $ | 2024 $ | Change $ | Change % | ||||||||||||
| Gross profit | 3,295 | 3,197 | 98 | 3.1 | % | |||||||||||
| % of total revenue | 54 | % | 51 | % |
Gross profit totaled $3.3 million during the three months ended January 31, 2025, an increase of 3.1% compared to the three months ended January 31, 2024. Gross profit increased due to reduction in material costs.
Research and development
| Three Months Ended January 31, | ||||||||||||||||
| (in thousands) | 2025 $ | 2024 $ | Change $ | Change % | ||||||||||||
| Research and development | 1,057 | 1,001 | 56 | 5.6 | % |
During the three months ended January 31, 2025, research and development expenses totaled $1.1 million, an increase from the $1.0 million incurred during the three months ended January 31, 2024. Research and development expenses for the three months ended January 31, 2025 include $0.6 million in salary costs, including share-based payments (2024 - $0.5 million), and $0.1 million in research expense (2024 - $0.2 million).
IMMUNOPRECISE ANTIBODIES LTD.
MANAGEMENT DISCUSSION AND ANALYSIS
FOR THE THREE AND NINE MONTHS ENDED JANUARY 31, 2025
| Three Months Ended January 31, | ||||||||||||||||
| (in thousands) | 2025 $ | 2024 $ | Change $ | Change % | ||||||||||||
| Sales and marketing | 1,310 | 649 | 661 | 101.8 | % |
Sales and marketing expenses totaled $1.3 million during the three months ended January 31, 2025, compared to $0.6 million during the three months ended January 31, 2024. Expenditures during the three months ended January 31, 2025, include $0.5 million in salary costs, including share-based payments (2024 - $0.4 million), and $0.7 million in advertising cost (2024 - $0.2 million).
General and administrative
| Three Months Ended January 31, | ||||||||||||||||
| (in thousands) | 2025 $ | 2024 $ | Change $ | Change % | ||||||||||||
| General and administrative | 3,594 | 4,178 | (584 | ) | -14.0 | % |
During the three months ended January 31, 2025, general and administrative expenses totaled $3.6 million, a decrease of $0.6 million compared to the three months ended January 31, 2024.
Other Income / Expense
| Three Months Ended January 31, | ||||||||||||
| (in thousands) | 2025 $ | 2024 $ | Change $ | |||||||||
| Accretion | (3 | ) | (5 | ) | 2 | |||||||
| Grant income | (4 | ) | (4 | ) | ||||||||
| Interest and other income (expense) | (169 | ) | 3 | (172 | ) | |||||||
| Unrealized foreign exchange gain (loss) | 114 | (115 | ) | 229 | ||||||||
| Total other income (expense) | (62 | ) | (117 | ) | 55 |
The Company recorded other income (expense) of $0.1 million during the three months ended January 31, 2025, compared to other income (expense) of $0.1 million during the three months ended January 31, 2024.
IMMUNOPRECISE ANTIBODIES LTD.
MANAGEMENT DISCUSSION AND ANALYSIS
FOR THE THREE AND NINE MONTHS ENDED JANUARY 31, 2025
Comparison of the nine months ended January 31, 2025 and 2024
| Nine Months Ended January 31, | ||||||||||||||||
| (in thousands) | 2025 $ | 2024 $ | Change $ | Change % | ||||||||||||
| Project revenue | 15,912 | 16,508 | (596 | ) | -3.6 | % | ||||||||||
| Product sales revenue | 1,452 | 1,372 | 80 | 5.8 | % | |||||||||||
| Cryostorage revenue | 175 | 179 | (4 | ) | -2.2 | % | ||||||||||
| Total revenue | 17,539 | 18,059 | (520 | ) | -2.9 | % |
The Company achieved revenue of $17.5 million during the nine months ended January 31, 2025, a 2.9% decrease from the nine months ended January 31, 2024.
| Nine Months Ended January 31, | ||||||||||||||||
| (in thousands) | 2025 $ | 2024 $ | Change $ | Change % | ||||||||||||
| Gross profit | 9,088 | 8,945 | 143 | 1.6 | % | |||||||||||
| % of total revenue | 52 | % | 50 | % |
Gross profit totaled $9.1 million during the nine months ended January 31, 2025, an increase of 1.6% compared to the nine months ended January 31, 2024. Gross profit increased due to reduction in salaries and material costs.