Full Press Release Details
Hoth Therapeutics and Zyl Therapeutics
Zyl and Hoth Therapeutics Forge
Partnership to Develop Endocannabinoid-Based Drug to Treat Lupus
Zyl 's xerogel-derived delivery
platform to be used to topically deliver the drug candidate
NEW YORK, NY August 21,
2019/PR Newswire/ Hoth Therapeutics, Inc. (Nasdaq: HOTH), a biopharmaceutical company focused on unique targeted therapeutics for
patients suffering from dermatological indications ranging from atopic dermatitis to chronic wound disorders, today announced it
has entered into a definitive partnership agreement with Zyl Therapeutics to develop a new treatment for patients suffering
from Cutaneous Lupus Erythematosus [CLE], a chronic autoimmune disease that affects the skin.
dedicated to bringing innovative topical technologies to multiple facets of medicine, has developed a patented topical delivery
system using xerogel-derived nanoparticles called Z-pods s, Hoth has an exclusive license to develop Anandamide-loaded Z-pods
for the treatment of CLE in North America. Anandamide, generally referred to as AEA, is one of the cannabinoids that the human
body makes naturally.
Hoth also has certain
rights related to geographic expansion and to follow-on indications such as psoriasis and rheumatoid arthritis.
Scientists at the Albert Einstein College of Medicine, where
the platform technology was originally developed, have demonstrated that topical administration with AEA-loaded Z-pods inhibits
the development of CLE lesions in a well-established animal model of lupus. This work reinforces and highlights the utility of
targeting the endocannabinoid system for autoimmune rheumatic diseases.
The work at Einstein supports the thesis
that AEA-loaded Z-pods :
According to estimates by the Lupus
Foundation of America [LFA], 1.5 million Americans currently suffer from lupus, with 16,000 new cases reported annually;
tragically, lupus strikes mostly women of child-bearing age and is 2-3 times more prevalent amongst women of color. Worldwide,
the LFA estimates that at least five million people have some form of the disease. Of those diagnosed, approximately two-thirds
will develop CLE. The average cost to provide medical treatment for a person with lupus is
well over $10,000 per year.
initial work with AEA-loaded Z-pods shows significant promise in treating CLE, and we look forward to collaborating with them to
bring this treatment to market," stated, Robb Knie, CEO of Hoth.
to partner with Hoth, an innovative company committed to developing treatment solutions for diseases-such as lupus-with
a high unmet clinical need," said Scott Pancoast, CEO of Zyl . "As we collaborate with the Hoth team to advance
AEA-loaded Z-pods through the next stages of development, we expect to further demonstrate the critical role that our patented
Z-pod delivery system plays in improving therapeutic outcomes."
About Hoth Therapeutics,
Hoth Therapeutics, Inc.,
a Nevada corporation, is a biopharmaceutical company focused on unique targeted therapeutics for patients suffering from
indications such as atopic dermatitis, also known as eczema. Hoth has exclusive worldwide rights to the BioLexa Platform.
About Zyl Therapeutics
Zyl has developed a xerogel-derived topical delivery system
that extends the duration-of-effect, improves the solubility/targeting, and/or enhances the product performance of many therapeutic
agents. Notably, the Z-pod technology platform has enabled the Patchless Patch concept and has successfully harnessed
the therapeutic potential of nitric oxide, one of the most powerful-and short-lived-biomolecules produced by the human
Forward Looking Statements
This press release includes "forward-looking statements"
within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements in this press release include,
but are not limited to, statements that relate to the advancement and development of the BioLexa Platform, the commencement of
clinical trials, the availability of data from clinical trials and other information that is not historical information. When used
herein, words such as "anticipate", "being", "will", "plan", "may", "continue",
and similar expressions are intended to identify forward-looking statements. In addition, any statements or information that refer
to expectations, beliefs, plans, projections, objectives, performance or other characterizations of future events or circumstances,
including any underlying assumptions, are forward-looking. All forward-looking statements are based upon Hoth's current expectations
and various assumptions. Hoth believes there is a reasonable basis for its expectations and beliefs, but they are inherently uncertain.
Hoth may not realize its expectations, and its beliefs may not prove correct. Actual results could differ materially from those
described or implied by such forward-looking statements as a result of various important factors, including, without limitation,
market conditions and the factors described under the caption "Risk Factors" in Hoth's Form 10K for the period ending December
31, 2018, and Hoth's other filings made with the Securities and Exchange Commission. Consequently, forward-looking statements should
be regarded solely as Hoth's current plans, estimates and beliefs. Investors should not place undue reliance on forward-looking
statements. Hoth cannot guarantee future results, events, levels of activity, performance or achievements. Hoth does not undertake
and specifically declines any obligation to update, republish, or revise any forward-looking statements to reflect new information,
future events or circumstances or to reflect the occurrences of unanticipated events, except as may be required by law.
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