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Filed by newsfilecorp.com FORM 51-102F3 MATERIAL CHANGE REPORT Item 1. Name and Address of Company Cybin Inc. (the " Company ") 100 King Street West, Suite 5600 Toronto, Ontario M5X 1C9 Item 2. Date of Material Change

Key Takeaway: Cybin Inc. announced a material change on September 2, 2025, as Doug Drysdale stepped down from his position as Chief Executive Officer. The Board appointed Eric So, Co-Founder and President, as the Interim CEO. The Board is actively seeking a new CEO to lead the company's commercialization efforts and to advance its mission of providing innovative mental healthcare solutions.

Market Sentiment Analysis

POSITIVE FACTORS

  • Eric So, a veteran with extensive experience, has been appointed as Interim CEO.
  • The Board is proactive in searching for a new CEO to lead future growth.
  • The company is committed to revolutionizing mental healthcare.

Full Press Release Details

MATERIAL CHANGE REPORT
Item 1. Name and Address of Company
Cybin Inc. (the "Company")
100 King Street West, Suite 5600
Item 2. Date of Material Change
Item 3. News Release
A news release with respect to the material change was disseminated by the Company on September 2, 2025 through Business Wire.
Item 4. Summary of Material Change
Effective September 2, 2025, Doug Drysdale stepped down as the Company's Chief Executive Officer. The Company's Co-Founder and President, Eric So, was appointed as Interim Chief Executive Officer by the Board of Directors.
Item 5. Full Description of Material Change
Effective September 2, 2025, Doug Drysdale stepped down as the Company's Chief Executive Officer. The Company's Co-Founder and President, Eric So, was appointed as Interim Chief Executive Officer by the Board of Directors.
Mr. So is a Co-Founder and Executive Chairman of the Company. He is a veteran owner, operator and investor in numerous companies over the last 20 years and has led corporate strategy, development, and finance at all stages of the business life cycle from start-up to growth stage and multinational.
The Board of Directors has established a committee to conduct a search for a new Chief Executive Officer. The Committee and the Board aim to move swiftly to bring onboard a new leader who will lead the Company through commercialization and ensure that the Company delivers on its commitment to revolutionizing mental healthcare by developing new and innovative next-generation treatment options for patients.
Item 6. Reliance on subsection 7.1(2) of National Instrument 51-102
Item 7. Omitted Information
Item 8. Executive Officer
Further information regarding the matters described in this report may be obtained from Gabriel Fahel,
Chief Legal Officer of the Company, who is knowledgeable about the details of the material change and may be contacted at 1-866-292-4601.
Item 9. Date of Report

Frequently Asked Questions

Who is the new Interim CEO of Cybin Inc.?

Eric So, Co-Founder and President, has been appointed as Interim CEO.

When did the CEO change occur at Cybin Inc.?

The CEO change took effect on September 2, 2025.

How will Cybin Inc. find a new CEO?

The Board established a committee to swiftly search for a new CEO.

Who can provide more information about the changes?

Gabriel Fahel, Chief Legal Officer, can provide further details.

What is Eric So's background?

Eric So has over 20 years of experience as an owner, operator, and investor.

Last updated: Sep 2, 2025