Forward-Looking Statements @2021 Galera Therapeutics, Inc. Certain information contained in this presentation and statements made orally during this presentation relates to or is based on studies, publications, surveys a

Transforming radiotherapy for patients

with cancer September 2021 Exhibit 99.1

Forward-Looking Statements @2021 Galera

Therapeutics, Inc. Certain information contained in this presentation and statements made orally during this presentation relates to or is based on studies, publications, surveys and other data obtained from third-party sources and Galera's

own internal estimates and research. While Galera believes these third-party sources to be reliable as of the date of this presentation, it has not independently verified, and makes no representation as to the adequacy, fairness, accuracy or

completeness of, any information obtained from third-party sources. While Galera believes its internal research is reliable, such research has not been verified by any independent source. This presentation contains "forward-looking

statements" within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements are neither historical facts nor assurances of future performance. Instead, they are based on our current beliefs, expectations

and assumptions regarding the future of our business, future plans and strategies, our clinical results and other future conditions. All statements other than statements of historical facts contained in this presentation, including statements

regarding future results of operations and financial position, business strategy, the safety, efficacy, regulatory and clinical progress, and therapeutic potential of current and prospective product candidates, plans and timing for the commencement

of and the release of data from clinical trials, our plans to prepare for commercialization and a US launch, the anticipated direct and indirect impact of COVID-19 on Galera's business and operations, planned clinical trials and preclinical

activities, potential product approvals and related commercial opportunity, current and prospective collaborations, and timing and likelihood of success, plans and objectives of management for future operations, are forward-looking statements. The

words "may," "will," "should," "expect," "plan," "anticipate," "could," "intend," "target," "project," "estimate,"

"believe," "predict," "potential" or "continue" or the negative of these terms or other similar expressions are intended to identify forward-looking statements, although not all forward-looking

statements contain these identifying words. The information in this presentation, including without limitation the forward-looking statements contained herein, represent our views as of the date of this presentation. Although we believe the

expectations reflected in such forward-looking statements are reasonable, we can give no assurance that such expectations will prove to be correct. Accordingly, readers are cautioned not to place undue reliance on these forward-looking statements.

Except as required by applicable law, we do not plan to publicly update or revise any forward-looking statements contained herein, whether as a result of any new information, future events, changed circumstances or otherwise. No representations or

warranties (expressed or implied) are made about the accuracy of any such forward-looking statements. The forward-looking statements in this presentation involve risks and uncertainties that could cause actual results to differ materially from those

reflected in such statements. Risks and uncertainties that may cause actual results to differ materially include uncertainties inherent in the drug development process and the regulatory approval process, our reliance on third parties over which we

may not always have full control, and other important risks and uncertainties that are described in Galera's Annual Report on Form 10-K for the year ended December 31, 2020 filed with the U.S. Securities Exchange Commission (SEC) and

Galera's other filings with the SEC. New risk factors and uncertainties may emerge from time to time, and it is not possible to predict all risk factors and uncertainties. Whenever the Company uses the terms "transform

radiotherapy" or "transforming radiotherapy" in this presentation, it is referring to its mission statement.

Radiation Therapy - Key Role in

Cancer Treatment Over 50% of all cancer patients receive radiation therapy as part of their treatment IMRT Intensity Modulated Radiation Therapy Low doses for weeks (~2 Gy/day) Most used form of external beam RT High doses for days (>5 Gy/day)

Cutting edge form of external beam RT Toxicity Efficacy Galera's Goal Radioprotection Galera's Goal Radiosensitization SBRT Stereotactic Body Radiation Therapy @2021 Galera Therapeutics, Inc.

Galera's Technology: Dismutase

Mimetics Mechanism of action is to convert RT-induced burst of Superoxide to Hydrogen Peroxide Toxicity Efficacy O2 Shifting the Balance H2O2 Radioprotection of Low Dose RT Radiosensitization of High Dose RT Superoxide (O2) is more damaging to

normal cells than cancer cells1 Hydrogen Peroxide (H2O2) is more toxic to cancer cells than normal cells2 @2021 Galera Therapeutics, Inc. 1Sonis S. Drug Design, Development and Therapy 2021:15 1021-1029 2Park WH: Oncol Rep 40: 1787-1794,

1The first SBRT combination trial used

GC4419 (avasopasem). Observations from this pilot trial used to guide development of GC4711 in combination with SBRT 2Global Cancer Statistics. Sung H et al. CA Cancer J Clin 2021;0:1-41 (excluding nonmelanoma skin cancer) 3US Cancer

Statistics Siegel RL et al. CA Cancer J Clin 2021;71:7-33 Transforming Radiotherapy Avasopasem Reducing IMRT Toxicity Breakthrough Therapy with Phase 3 Fully Enrolled GC4711 Increasing SBRT Efficacy Large Markets with High Unmet Need

Encouraging Survival Data in Pancreatic Cancer Trial1 18 Million New Cancers in World in 20202 (1.9M in US) Severe Oral Mucositis In Head & Neck Cancer Esophagitis in Lung Cancer Pancreatic Cancer Locally Advanced Lung Cancer Locally Advanced

Radiotherapy needed by over half of patients with cancer Galera building US commercial team for Avasopasem Launch @2021 Galera Therapeutics, Inc.

Head & Neck Cancer Lung Cancer

Pancreatic Cancer Robust Pipeline @2021 Galera Therapeutics, Inc. Phase 1 Next Anticipated Milestone IMRT induced Severe Oral Mucositis1 1EUSOM is a single-arm multi-center trial evaluating the safety and efficacy of avasopasem in patients with HNC

in Europe 2Phase 2a trial in patients with lung cancer building on avasopasem safety and tolerability findings from SOM trials in patients with HNC 3Trial to assess anti-cancer efficacy of SBRT +/- GC4711; subsequently, intend to assess anti-cancer

efficacy of SBRT and checkpoint inhibitor +/- GC4711 4The first SBRT combination trial used GC4419 (avasopasem). Observations from this pilot trial used to guide development of GC4711 in combination with SBRT Phase 2 Phase 3 Topline Data: 4Q 2021

Topline Data: 4Q 2021 SBRT Combo3 Topline Data: 1H 2022 Initial Data: 1H 2022 IMRT induced Esophagitis2 Final Data: 3Q 2021 Initiated Trial: 2Q 2021 SBRT Combo4 ROMAN: Avasopasem vs. Placebo EUSOM: Avasopasem AESOP: Avasopasem GRECO-1: GC4711 vs.

Placebo Pilot: GC4419 vs. Placebo GRECO-2: GC4711 vs. Placebo Both Trials Fully Enrolled

Reducing IMRT Toxicity

Lung Cancer Receiving 6 weeks IMRT

& Chemo Head & Neck Cancer Receiving 7 weeks IMRT & Cisplatin Radioprotection Programs Phase 1 Next Anticipated Milestone Phase 2 Phase 3 Esophagitis2 Severe Oral Mucositis1 Topline Data: 4Q 2021 Topline Data: 4Q 2021 Topline Data: 1H

2022 Completed & Published4 Completed & Published3 455 38 60 223 43 Pts @2021 Galera Therapeutics, Inc. 1EUSOM is a single-arm multi-center trial evaluating the safety and efficacy of avasopasem in patients with HNC in Europe 2Phase 2a trial

in patients with lung cancer building on avasopasem safety and tolerability findings from SOM trials in patients with HNC 3Anderson CM et al. Int J Radiat Oncol Biol Phys. 2018 Feb 1;100(2):427-435 4Anderson CM et al. J Clin Oncol.

2019;37(34):3256-3265. ROMAN: Avasopasem vs. Placebo EUSOM: Avasopasem AESOP: Avasopasem RP2b: Avasopasem vs. Placebo Ph 1b/2a: Avasopasem

Severe Severe Oral Mucositis in Head

& Neck Cancer @2021 Galera Therapeutics, Inc. The most burdensome toxicity of standard-of-care chemoradiotherapy (radiotherapy & cisplatin) 70% Patients Get SOM (Grade 3 or 4 OM) WHO Grading System Current Approaches Lack Efficacy Physicians

Consider Topicals Ineffective MASCC Guidelines focus only on symptoms1 Market Research with 150 Radiation Oncologists2 Basic Oral care Opioids, anesthetics Coating agents Benzydamine Anti-inflammatories Only 20% of physicians believe topical agents

perform well for oral mucositis 1 No ulcers Erythema & soreness 3 Ulcers Require liquid diet 4 Ulcers Unable to eat or drink 2 Ulcers Able to eat solid diet 1Elad S et al, MASCC/ISOO Clinical Practice Guidelines for the Management of Mucositis

Secondary to Cancer Therapy. Cancer 2020;126:4423-4431 2Galera Market Research

60-minute IV infusion just before

IMRT Multicenter (North America) Placebo x 7 weeks Avasopasem 90mg x 7 weeks 455 Patient ROMAN Phase 3 Trial - Results this Year @2021 Galera Therapeutics, Inc. Fully Enrolled Randomized Placebo-Controlled Severe Oral Mucositis Trial

Population Treatment Endpoints Patients with Head & Neck Cancer (locally advanced) Receiving standard IMRT and cisplatin over 7 weeks 70% expected to get SOM Primary: Reduction in the incidence of SOM Secondary: Reduction in SOM duration &

severity R Randomized 3:2

Avasopasem: First-to-Market

Potential @2021 Galera Therapeutics, Inc. Avasopasem Prevents RT Injury Patients get avasopasem before each RT dose Avasopasem has BTD for Oral Mucositis 455 Patient ROMAN Phase 3 Trial FDA Breakthrough Therapy Designation Data anticipated 4Q 2021

Blocks initiating injury in normal cells from RT burst of superoxide Does not interfere with RT anti-cancer efficacy BTD granted for oral mucositis in February 2018 Based on robust Phase 2b data in 223 patients Enrollment complete Single Phase 3

sufficient for NDA with Phase 2b as supportive

60-minute IV infusion just before

IMRT Multicenter (North America) Placebo x 7 weeks R Avasopasem 90mg x 7 weeks Avasopasem 30mg x 7 weeks 223 Patient Phase 2b Trial - Robust Results @2021 Galera Therapeutics, Inc. Randomized Placebo-Controlled Severe Oral Mucositis (SOM)

Trial Population Treatment Endpoints Patients with Head & Neck Cancer (locally advanced) Receiving standard IMRT and cisplatin over 7 weeks 70% expected to get SOM Primary: Reduction in SOM duration Secondary: Reduction in SOM incidence &

Incidence Duration Severity

Consistent and Encouraging Results @2021 Galera Therapeutics, Inc. Across SOM Endpoints p=0.024 p=0.009* p=0.045* 34% 92% 47% Reduction in SOM incidence Reduction in median days of SOM Reduction in incidence of Grade 4 OM Anderson CM et al. Journal

of Clinical Oncology 2019 37:34, 3256-3265 *Secondary endpoints (incidence and severity) have nominal p values compared to placebo Intent-To-Treat (ITT) Population

Avasopasem Efficacy Significantly

Better than Placebo @2021 Galera Therapeutics, Inc. FOLLOW UP POST THERAPY FOLLOW UP POST THERAPY RADIOTHERAPY TREATMENT PERIOD RADIOTHERAPY TREATMENT PERIOD Grade 4 Grade 3 90 mg Avasopasem 34% Less Incidence SOM 47% Less Grade 4 OM 92% Shorter

Duration SOM Delayed Onset of SOM PLACEBO Arm (45 of 74 Pts had 1 visit with SOM) 90MG Avasopasem Arm (35 of 76 Pts had 1 visit with SOM) Anderson CM et al. Journal of Clinical Oncology 2019 37:34, 3256-3265

Radiotherapy Efficacy Maintained

Over Two Years @2021 Galera Therapeutics, Inc. Final ITT Analysis

Safety Results Comparable to Placebo

@2021 Galera Therapeutics, Inc. Avasopasem Generally Well Tolerated Most Frequent AEs (any grade) Placebo (n=72) 30 mg Avasopasem (n=73) 90 mg Avasopasem (n=72) Lymphopenia 89% 92% 88% Nausea 75% 68% 82% Fatigue 69% 60% 65% Oropharyngeal pain 64%

63% 61% Constipation 53% 59% 64% Radiation skin injury 47% 51% 53% Vomiting 47% 52% 49% Dysgeusia (taste) 49% 55% 43% Dysphagia 43% 42% 47% Weight decreased 35% 40% 44% Oral candidiasis 29% 45% 43% Leukopenia 39% 37% 39% Anderson CM et al. Journal

of Clinical Oncology 2019 37:34, 3256-3265

SOM Market Opportunity

Head and Neck Cancer - Large

Market Opportunity @2021 Galera Therapeutics, Inc. 650,000 Global Head & Neck Cancer Incidence 65,630 42,000 US Patients Diagnosed each year US Patients at Risk for RT-related SOM Initial Target Population Severe Oral Mucositis is most

burdensome side effect - 70% get SOM Locally advanced HNC is curable with the standard-of-care IMRT and cisplatin regimen

Head and Neck Cancer Can Affect

Anyone Babe Ruth, Lana Turner, Jamie Dimon, Ulysses S. Grant, Sigmund Freud, Humphrey Bogart, Grover Cleveland, Eddie Van Halen Sammy Davis Jr., George Harrison, Michael Douglas, Ann Richards, Tony Gwynn @2021 Galera Therapeutics, Inc.

Concentrated Physician Population

@2021 Galera Therapeutics, Inc. 700 5,000 Radiation Oncologists in U.S 2,500 Radiotherapy Treatment Sites Top centers where >80% HNC patients are treated Initial Sales Focus SOM is most burdensome side effect of curative IMRT + cisplatin regimen

38% IMRT centers currently infuse drugs1 34% more coordinate with medical oncology to infuse patients Additional 17% can add capabilities to infuse patients 72% Sites with Existing Infusion Capability1 64% Market Patient Share 1Primary market

research with 125 IMRT centers in the US

Where Patients with Head & Neck

Cancer are Treated @2021 Galera Therapeutics, Inc. 76% Treated in only 29% Zip Code areas Galera Market Research (122 Zip Codes are 0)

Most Centers Have Ability to Infuse

Today @2021 Galera Therapeutics, Inc. 72% Radiotherapy Sites Have Existing Infusion Capability Adoption Archetype Determinants A Rad Oncs Have Current Capabilities B Med Oncs Administer Infusions for Rad Onc C Rad Oncs Need to Add Capabilities D Rad

Oncs Unlikely to Add Capabilities Total % Sample Distribution 38% 34% 17% 11% Avasopasem Infusion Owner Rad Onc Med Onc Rad Onc - Ease of Coordination Today High High Low Low Likelihood of Prescribing Avasopasem High High High Low Data in above

table based on primary research with 125 IMRT centers in the US

US Radiation Oncologists Trending

Away from Private Practice @2021 Galera Therapeutics, Inc. 1Data from ASTRO

@2021 Galera Therapeutics, Inc.

$40,000 Additional medical expenses incurred by patients who develop OM $15-25K Indicative price of full course of therapy based on initial payer research Step Edits Unlikely High unmet need with limited treatment options Price strategy intended to

optimize patient access Head and neck cancer not a focus for cost control measure Favorable Payer Landscape

Beyond Oral Mucositis: Other

RT-Related Toxicities @2021 Galera Therapeutics, Inc. Physicians view oral mucositis data as potentially applicable to other radiation-related toxicities 150 Rad Oncs were asked the following: Given the demonstrated ability of Product X to prevent

radiation-induced toxicities in the oral mucosa, please indicate how you might use (maximum %) Product X for the following radiation associated conditions? Galera primary research with 150 Radiation Oncologists

Esophagitis in Lung Cancer @2021

Galera Therapeutics, Inc. 2,500,000 Global NSCLC Incidence 175,000 50,000 US Patients Diagnosed each year US Patients at Risk for RT-related Esophagitis Initial Target Population Locally advanced NSCLC frequently treated with IMRT and

Esophagitis: Major Unmet Need in

Lung Cancer @2021 Galera Therapeutics, Inc. Common Side Effect of Chemoradiotherapy (IMRT x 6 weeks) 50% Patients Get Grade 2+ Esophagitis RTOG Grading System Current Approaches Lack Efficacy AESOP Trial Design No established drug therapy Phase 2