First Wave BioPharma Announces Exercise of Warrants and Issuance of New Warrants in a Private Placement for $4.8 Million Gross Proceeds Priced

Wave BioPharma Announces Exercise of Warrants and Issuance of New Warrants in a Private Placement for $4.8 Million Gross Proceeds Priced

Fla., December 27, 2023 (GLOBE NEWSWIRE) -- First Wave BioPharma, Inc. ("First Wave BioPharma" or the "Company")

(NASDAQ: FWBI), a clinical-stage biopharmaceutical company specializing in the development of targeted, non-systemic therapies for gastrointestinal

(GI) diseases, today announced it has entered into agreements with certain holders of its existing warrants exercisable for 881,337 shares

of its common stock, in the aggregate, to exercise their warrants at a reduced exercise price of $5.50 per share, in exchange for new

warrants as described below. The aggregate gross proceeds from the exercise of the existing warrants is expected to total approximately

$4.8 million, before deducting financial advisory fees. The reduction in the exercise price of the existing warrants and the issuance

of the new warrants was structured as an at-market transaction under Nasdaq rules.

Partners is acting as the Company's financial advisor for this transaction.

of common stock issuable upon exercise of the existing warrants are registered for resale pursuant to a resale registration statements

on Form S-3 (File No. 333-2744634) which was declared by the Securities and Exchange Commission (SEC) on September 29, 2023, a resale

registration statement on Form S-3 ((File No. 333-274634) which was declared effective by the SEC on September 29, 2023, and a

resale registration statement on Form S-1 (File No. 333-272404) which ws declared effective by the SEC on July 17, 2023.

for the immediate exercise of the existing warrants for cash and the payment of $0.125 per share underlying the new warrants, the exercising

holders will receive new warrants to purchase shares of common stock in a private placement pursuant to Section 4(a)(2) of the Securities

Act of 1933, as amended (the "1933 Act"). The new warrants will be exercisable into an aggregate of up to 1,762,674 shares

of common stock, at an exercise price of $5.00 per share and have a term of exercise equal to five years. The securities offered in the

private placement have not been registered under the Securities Act of 1933, as amended, or applicable under state securities laws. Accordingly,

the securities may not be offered or sold in the United States except pursuant to an effective registration statement or an applicable

exemption from the registration requirements of the Securities Act and such applicable state securities laws. As part of the transaction,

the Company has agreed to file a resale registration statement on Form S-3 with the Securities and Exchange Commission within 10 days

of the closing to register the resale of the shares of common stock underlying the new warrants issued in the private placement.

release does not constitute an offer to sell or the solicitation of an offer to buy these securities, nor shall there be any sale of these

securities in any jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification

under the securities laws of any such jurisdiction.

About First Wave BioPharma, Inc.

First Wave BioPharma is a clinical-stage biopharmaceutical

company specializing in the development of targeted, non-systemic therapies for gastrointestinal (GI) diseases. The Company is currently

advancing a therapeutic development pipeline with multiple late-stage clinical stage programs, including Capeserod, a selective 5-HT4

receptor partial agonist which First Wave is developing for gastrointestinal (GI) indications; the biologic Adrulipase, a recombinant

lipase enzyme designed to enable the digestion of fats and other nutrients in cystic fibrosis and chronic pancreatitis patients with exocrine

pancreatic insufficiency; and it is anticipated that the Company will soon acquire Latiglutenase, a targeted, oral first-in-class biotherapeutic

for celiac disease. First Wave BioPharma is headquartered in Boca Raton, Florida. For more information visit www.firstwavebio.com.

Forward-Looking Statement

may contain certain statements relating to future results which are forward-looking statements. It is possible that the Company's

actual results and financial condition may differ, possibly materially, from the anticipated results and financial condition indicated

in these forward-looking statements, depending on factors including whether a definitive agreement for the Proposed Transaction or a transaction

with ImmunogenX and any concurrent financing or licensing transaction will be entered into; whether such transactions, or any other contemplated

transaction, may be completed with different terms, in an untimely manner, or not at all; whether the Company will be able to realize

the benefits of the Proposed Transaction described herein; the Company's ability to integrate the assets and commercial operations

contemplated to be acquired from ImmunogenX into the Company's business; whether results obtained in preclinical and nonclinical

studies and clinical trials will be indicative of results obtained in future clinical trials; whether preliminary or interim results from

a clinical trial will be indicative of the final results of the trial; whether the Company will be able to maintain compliance with Nasdaq's

continued listing criteria and the effect of a delisting from Nasdaq on the market for the Company's securities; the size of the

potential markets for the Company's drug candidates and its ability to service those markets; the effects of the First Wave Bio,

Inc. acquisition, the related settlement and their effect on the Company's business, operating results and financial prospects;

and the Company's current and future capital requirements and its ability to raise additional funds to satisfy its capital needs.

Additional information concerning the Company and its business, including a discussion of factors that could materially affect the Company's

financial results are contained in the Company's Annual Report on Form 10-K for the year ended December 31, 2022, under the heading

"Risk Factors," as well as the Company's subsequent filings with the Securities and Exchange Commission. All forward-looking

statements included in this press release are made only as of the date of this press release, and we do not undertake any obligation to

publicly update or correct any forward-looking statements to reflect events or circumstances that subsequently occur or of which we hereafter

For more information:

First Wave BioPharma, Inc.

777 Yamato Road, Suite 502

Boca Raton, FL 33431

Phone: (561) 589-7020

Tiberend Strategic Advisors, Inc.