Full Press Release Details
Structure Therapeutics
Announces Selection of Lead Oral Small Molecule
Amylin Receptor Agonist ACCG-2671 for the Treatment of Obesity
with ACCG-2671 demonstrate potent target engagement, robust weight loss,
favorable safety profile and PK properties supportive of once-daily
the most advanced oral small molecule amylin-based drug candidate,
with Phase 1 study initiation expected by year end 2025
conference call today at 4:30 p.m. Eastern Time
SAN FRANCISCO - December 17,
2024 - Structure Therapeutics Inc. (NASDAQ: GPCR), a clinical-stage global biopharmaceutical company developing novel oral
small molecule therapeutics for metabolic diseases, today announced the selection of its lead oral small molecule amylin receptor agonist,
ACCG-2671. Amylin is a hormone that plays an important role in regulating glycemia and energy balance and is recognized as a promising
therapeutic target for obesity and related diseases due to its effects on reducing food intake and slowing the rate of gastric emptying.
ACCG-2671 was designed as an oral small molecule Dual Amylin and Calcitonin Receptor Agonist (DACRA) and is expected to enter Phase 1
clinical development by year end 2025.
"We believe amylin-based therapies
are an important next-generation component of the treatment landscape for obesity and related conditions due to their potential for significant
weight loss, favorable tolerability profile, and lean muscle mass preservation," said Raymond Stevens, Ph.D., Founder and Chief
Executive Officer of Structure Therapeutics. "As an oral small molecule, we envision ACCG-2671 as an additional backbone therapy
to improve scalability, combinability and ultimately expand patient access to amylin-based weight loss medicines. We are in a unique
position to have a potentially best in class GLP-1 oral small molecule with GSBR-1290 and now the most advanced amylin oral small molecule,
both intended for use as monotherapies and as backbones for fixed dose oral combinations."
In preclinical studies, ACCG-2671 demonstrated
potent and balanced in vitro activities toward the key amylin receptor and the calcitonin receptor. ACCG-2671 also further demonstrated
robust in vivo efficacy and a pharmacokinetic (PK) and safety profile supporting once-daily oral dosing in humans.
"The preclinical data demonstrate
cagrilintide-like efficacy with an oral small molecule profile, underscoring ACCG-2671's potential as a meaningfully differentiated
oral treatment for obesity and related conditions," said Xichen Lin, Ph.D., Chief Scientific Officer of Structure Therapeutics.
"Our proven GPCR structure-based
drug discovery platform enabled us to rapidly advance ACCG-2671 as the lead amylin receptor agonist. We are now developing a series of
amylin-based drug candidates using our technology platform to maintain our leadership in this exciting space."
Conference Call and Webcast Information
Structure Therapeutics will host a conference
call and webcast today, December 17, 2024 at 4:30 p.m. Eastern Time. A live webcast of the call will be available on the Investor Relations
page of Structure Therapeutics' website at https://ir.structuretx.com/events-presentations/events. To access the call by
phone, participants can use the dial-in numbers listed below:
US-based Investors: 1-844-826-3033
International Investors: 1-412-317-5185
Conference Call ID: 10195088
The webcast will be made available for
replay on Structure Therapeutics' website beginning approximately two hours after the live event. The replay of the webcast will
be available for 90 days.
About Amylin, Amylin-based receptor
agonists, and ACCG-2671
Amylin is co-secreted with insulin from
pancreatic beta cells in response to nutrient ingestion. Amylin has important physiological effects including reducing appetite, increasing
satiety, leptin sensitivity and energy expenditure. Preclinical data from current amylin-based treatments in development suggest a potential
for amylin to reduce fat mass and preserve lean mass.
Two types of amylin-based treatments
for the treatment of obesity are currently being developed: dual amylin and calcitonin receptor agonists (DACRAs) that target both the
amylin and calcitonin receptors; and selective amylin receptor agonists (SARAs) that preferentially target the amylin receptor.
Structure Therapeutics is developing a series of both DACRAs and SARAs, as both approaches have demonstrated potential as obesity and
chronic weight management treatment. Structure's lead amylin-based molecule, ACCG-2671, is a DACRA that is being evaluated for
use either alone or in combination with GLP-1R agonists to treat obesity and associated diseases. ACCG-2671 is the first disclosed oral
small molecule amylin-based development candidate, with Phase 1 study initiation expected by year end 2025.
About Structure Therapeutics
Structure Therapeutics is a science-driven
clinical-stage biopharmaceutical company focused on discovering and developing innovative oral small molecule treatments for chronic
metabolic and cardiopulmonary conditions with significant unmet medical needs. Utilizing its next generation structure-based drug discovery
platform, Structure Therapeutics has established a robust GPCR-targeted pipeline, featuring multiple wholly-owned proprietary clinical-stage
small molecule compounds designed to surpass the scalability limitations of traditional biologic and peptide therapies and be accessible
to more patients around the world. For additional information, please visit www.structuretx.com.
Forward Looking Statements
This press release contains
"forward-looking statements" within the meaning of the "safe harbor" provisions of the Private Securities
Litigation Reform Act of 1995. All statements other than statements of historical fact are statements that could be deemed
forward-looking statements, including, without limitation, statements concerning: the Company's future plans and prospects;
any expectations regarding the safety, efficacy, tolerability, scalability or combinability of ACCG-2671, GSBR-1290 and other
candidates under development; the ability of ACCG-2671 and GSBR-1290 to treat T2DM, obesity or related indications; the planned
initiation of ACCG-2671's Phase 1 clinical study; the potential for ACCG-2671 and GSBR-1290 to be the most advanced and/or a
best-in-class oral small molecule; and the ability of the Company to expand patient access to amylin-based weight loss medicines;.
In addition, when or if used in this press release, the words and phrases "expect," "on track,"
"plan," "potential," "promising," "to be," and similar expressions and their
variants, as they relate to the Company may identify forward-looking statements. Forward-looking statements are neither historical
facts nor assurances of future performance. Although the Company believes the expectations reflected in such forward-looking
statements are reasonable, the Company can give no assurance that such expectations will prove to be correct. Readers are cautioned
that actual results, levels of activity, safety, performance or events and circumstances could differ materially from those
expressed or implied in the Company's forward-looking statements due to a variety of risks and uncertainties, which include,
without limitation, risks and uncertainties related to the preliminary nature of the results due to length of the study and sample
size and results from earlier clinical studies not necessarily being predictive of future results, potential delays in the
commencement, enrollment and completion of the Company's planned and current clinical studies, the Company's ability to
advance GSBR-1290, LTSE-2578, ANPA-0073, ACCG-2671 and its other therapeutic candidates, obtain regulatory approval of and
ultimately commercialize the Company's therapeutic candidates, competitive products or approaches limiting the commercial
value of the Company's product candidates, the timing and results of preclinical and clinical studies, the Company's
ability to fund development activities and achieve development goals, the Company's reliance on third parties, including clinical
research organizations, manufacturers, suppliers and collaborators, over which it may not always have full control, the impact of
any global pandemics, inflation, supply chain issues, rising interest rates, future bank failures and other macroeconomic factors on
the Company's business, its ability to protect its intellectual property and other risks and uncertainties described in
the Company's filings with the Securities and Exchange Commission (SEC), including the Company's Annual Report on Form
10-K for the year ended December 31, 2023, as filed with the SEC on March 8, 2024, the Quarterly Report on Form 10-Q for the quarter
ended September 30, 2024 filed with the SEC on November 13, 2024, and future reports the Company may file with the SEC from time to
time. All forward-looking statements contained in this press release speak only as of the date on which they were made and are based
on management's assumptions and estimates as of such date. The Company undertakes no obligation to update such statements to
reflect events that occur or circumstances that exist after the date on which they were made, except as required by law.
Structure Therapeutics Inc.