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Genmab and AbbVie Announce Epcoritamab in Combination with R-CHOP Demonstrates Statistically Significant Improvement in Progression-Free Survival in Patients with Newly Diagnosed Diffuse Large B-Cell Lymphoma

Key Takeaway: Genmab and AbbVie have reported positive topline results from their Phase 3 EPCORE DLBCL-2 trial. The trial evaluated the efficacy of epcoritamab combined with R-CHOP in newly diagnosed diffuse large B-cell lymphoma patients. Results indicate a statistically significant improvement in progression-free survival compared to R-CHOP alone.

Market Sentiment Analysis

POSITIVE FACTORS

  • Epcoritamab shows statistically significant improvement in progression-free survival.
  • The combination with R-CHOP demonstrates enhanced treatment efficacy.
  • Positive topline results from a Phase 3 clinical trial.

BiopharmaWatch Analysis

From our catalyst data and publicly available data · not financial advice
Best trade, last catalyst
+17%
120-day peak, hindsight
Typical move
1.5%
average across 4 past catalysts
Lead asset
Petosemtamab
Phase 3 · Left-sided Colorectal Cancer

Full Press Release Details

COPENHAGEN, Denmark & NORTH CHICAGO, Ill.--(BUSINESS WIRE)--Genmab A/S (Nasdaq: GMAB) and AbbVie (NYSE: ABBV) announced today positive topline results from the Phase 3 EPCORE DLBCL-2 trial evaluating fixed treatment duration epcoritamab, a T-cell engaging bispecific antibody administered subcutaneously, in combination with standard of care rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine, and prednisone (R-CHOP), compared to R-CHOP alone, in newly diagnosed patients with diff

Frequently Asked Questions

What is the EPCORE DLBCL-2 trial?

The EPCORE DLBCL-2 trial is a Phase 3 study evaluating epcoritamab with R-CHOP in DLBCL patients.

What were the results of the trial?

The trial showed a statistically significant improvement in progression-free survival with epcoritamab.

What is R-CHOP?

R-CHOP is a standard chemotherapy regimen consisting of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone.

Who conducted the trial?

The trial was conducted by Genmab and AbbVie.

Last updated: Oct 5, 2026