GLYCOMIMETICS REPORTS SECOND QUARTER 2014

GLYCOMIMETICS REPORTS SECOND QUARTER 2014 RESULTS

GAITHERSBURG, MD, July 31, 2014 GlycoMimetics, Inc. (NASDAQ: GLYC) today reported financial results for the second quarter ended

June 30, 2014. As of June 30, 2014, GlycoMimetics had cash and cash equivalents of $66.2 million, which reflects the company s net proceeds of $57.2 million from its January 2014 initial public offering (IPO) and a $15.0 million

non-refundable milestone payment received from Pfizer in May 2014 under the parties collaboration for the drug candidate rivipansel (previously known as GMI-1070).

The company recognized the full $15.0 million payment from Pfizer as revenue during the quarter ended June 30, 2014. Under the terms of its agreement

with Pfizer, GlycoMimetics will be entitled to receive an additional milestone payment of $20.0 million upon the initiation of dosing of the first patient with rivipansel in a Phase 3 trial, which Pfizer will conduct. The company currently expects

the initiation of the Phase 3 clinical trial to occur in the second half of 2014.

The company s research and development expenses increased to $5.4

million for the quarter ended June 30, 2014 as compared to $2.9 million for the second quarter of 2013. This increase reflects spending for advanced pre-clinical testing, clinical testing and manufacturing of the company s drug candidate

GMI-1271 for the treatment of acute myeloid leukemia (AML) and other cancers, as well as a $1.5 million license fee payment to be made to the University of Basel as a result of the company having received the $15.0 million non-refundable milestone

payment from Pfizer in May 2014.

The company s general and administrative expenses increased to $1.6 million for the quarter ended June 30,

2014 as compared to $0.7 million for the second quarter of 2013. The increase was primarily due to costs associated with the IPO and supporting public company operations.

Our second quarter achievements reflect important progress in advancing our lead drug candidate and our emerging clinical pipeline, said Rachel

King, CEO of GlycoMimetics. Our receipt of Pfizer s $15 million milestone payment signals our partner s diligence and commitment to advancing rivipansel to Phase 3, as does the early July announced achievement of a special protocol

assessment (SPA) agreement from the FDA. In addition, with the initiation of our Phase 1 trial of GMI-1271 for treatment of AML and other blood cancers, we have the opportunity to demonstrate the productivity of our robust glycomimetic technology

platform. Our preclinical data, along with our current cash, position us well to explore proprietary development for this niche opportunity or perhaps to partner in the future if we can achieve compelling clinical results.

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About GlycoMimetics, Inc.

GlycoMimetics is a clinical

stage biotechnology company focused on the discovery and development of novel glycomimetic drugs to address unmet medical needs resulting from diseases in which carbohydrate biology plays a key role. Glycomimetics are molecules that mimic the

structure of carbohydrates involved in important biological processes. Using its expertise in carbohydrate chemistry and knowledge of carbohydrate biology, GlycoMimetics is developing a pipeline of glycomimetic drug candidates that inhibit

disease-related functions of carbohydrates, such as the roles they play in inflammation, cancer and infection.

Cautionary Note on Forward-Looking

The statements in this press release that are not historical facts constitute forward-looking statements that involve risks and

uncertainties and are made pursuant to the Private Securities Litigation Reform Act of 1995. These forward-looking statements may be identified by their use of terms and phrases such as anticipate, believe,

estimate, expect, intend, may, plan, predict, project, target, potential, will, would, could,

should, continue, and similar expressions, or the negative of such terms, and include, but are not limited to, GlycoMimetics expectations regarding potential payments under its collaboration with Pfizer and its planned

activities with respect to the clinical development of GMI-1271. Actual results may differ materially from those expressed or implied by these forward-looking statements as a result of a number of important factors, including the availability and

timing of data from ongoing clinical trials, the uncertainties inherent in the initiation of future clinical trials, whether interim results from a clinical trial will be predictive of the final results of the trial or results of early clinical

trials will be indicative of the results of future trials, expectations for regulatory approvals, availability of funding sufficient for GlycoMimetics foreseeable and unforeseeable operating expenses and capital expenditure requirements, other

matters that could affect the availability or commercial potential of GlycoMimetics drug candidates, and other factors discussed in the Risk Factors sections of the company s Annual Report on Form 10-K for the year ended

December 31, 2013 that was filed with the U.S. Securities and Exchange Commission (SEC) on March 31, 2014, and in other filings GlycoMimetics makes with the SEC from time to time. The forward-looking statements included in this press

release represent GlycoMimetics views as of the date of this release and should not be relied

upon as representing the company s views as of any date subsequent to the date hereof. GlycoMimetics anticipates that subsequent events and developments may cause its views to change.

However, while GlycoMimetics may elect to update these forward-looking statements at some point in the future, it undertakes no obligation to update or revise these statements, except as may be required by law.

Condensed Statements of Operations

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