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TwinStrand Biosciences Announces Second U.S. Patent Trial and Appeal Board Decision Upholding All Claims of TwinStrand’s ‘127 Patent

Key Takeaway: TwinStrand Biosciences announced that the U.S. Patent Trial and Appeal Board has upheld all claims of its core patent related to Duplex Sequencing technology. This decision follows a challenge from Guardant Health, which was rejected by the PTAB. The ruling reinforces TwinStrand's intellectual property position and supports the validity of its innovative technology.

Market Sentiment Analysis

POSITIVE FACTORS

  • PTAB upheld all claims of TwinStrand's core patent.
  • Rejection of Guardant Health's challenge strengthens TwinStrand's position.
  • Affirmation of Duplex Sequencing technology's validity.

Full Press Release Details

SEATTLE--(BUSINESS WIRE)--TwinStrand Biosciences (TwinStrand), the pioneer in Duplex Sequencing® technology, today announced that the U.S. Patent and Trademark Office’s Patent Trial and Appeal Board (PTAB) has again rejected Guardant Health, Inc.’s (Nasdaq: GH) challenge to a core patent underlying Duplex Sequencing. In an Oct. 14, 2026, Final Written Decision on remand from the U.S. Court of Appeals for the Federal Circuit, the PTAB ruled in favor of the University of Washington (UW), determin

Frequently Asked Questions

What did the PTAB decide regarding TwinStrand's patent?

The PTAB upheld all claims of TwinStrand's core patent related to Duplex Sequencing.

Who challenged TwinStrand's patent?

Guardant Health, Inc. challenged TwinStrand's patent claims.

What technology is associated with TwinStrand's patent?

The patent is associated with Duplex Sequencing technology.

When was the PTAB's decision made?

The PTAB's decision was announced on October 14, 2026.

Last updated: Oct 15, 2026