Full Press Release Details
Therapeutics signs Business & Research Collaboration Agreement with India's SunAct Cancer Institute Private Limited to advance
use of allogeneic off-the-shelf Gamma Delta T Cells for treatment of solid cancers in a proposed Phase 2 clinical trial in India
- (January 6, 2025) - CytoMed Therapeutics Limited (NASDAQ: GDTC) ("CytoMed" or "Company"),
a Singapore-based clinical stage biopharmaceutical company focused on harnessing its proprietary technologies to develop novel donor-derived
cell-based allogeneic off-the-shelf immunotherapies for the treatment of various cancers, today announced that it has entered into a
Business & Research Collaboration Agreement ("BRCA") with Mumbai-based SunAct Cancer Institute Private Limited ("SunAct"),
a company incorporated in the Republic of India ("India").
BRCA forms a collaborative effort between CytoMed and SunAct to explore and investigate the safety, tolerability, potency, and efficacy
of CytoMed's proprietary allogeneic gamma delta T cells for the treatment of various cancers (including solid tumors) in human
subjects through clinical research, including a Phase 2 investigator-initiated trial ("Clinical Trial") in India. CytoMed
and SunAct will be the joint sponsors of the Clinical Trial, working with the medical team in the SunAct Cancer Institute, led by Prof
Dr Vijay Patil, a renowned medical oncologist and immunotherapy specialist in India and the founder of SunAct.
this research and undertaking the accelerated Clinical Trial in the form of a combined Phase 1 and Phase 2 Clinical Trial targets not
just the safety and efficacy of the therapeutic application and intervention of allogeneic gamma delta T Cells in the treatment of solid
cancers but also expedites the gathering of information and data on the initial safety, preliminary efficacy and optimal dosing. We expect
to identify the types of cancers the therapy will work for, including the side effects of the same if any and how we might manage them,"
said Dr Vijay Patil. "We are excited and eager to commence and accelerate the study. This collaboration with CytoMed will provide
alternative treatment for a wide range of solid cancers at a reduced cost to an increasing host of the population of India suffering
from the effects of cancer. We aim to provide much needed access to and treatment for cancer at an affordable cost and to contribute
to an increasing and much needed global data pool in our quest for a solution to fight cancer."
commitment in the advancement of cancer immunotherapy, harnessing the ability of the immune system and application of immunotherapies
is supported by the development and approval of international collaborations and clinical trials regulated by the Central Drugs Standard
Control Organization (CDSCO) of India, and incentives such as grants for research in the relevant field, which can potentially help to
reduce the cost of clinical research in India.
Chairman Peter Choo added, "CytoMed's collaboration with SunAct is timely and complements our core focus of harnessing CytoMed's
proprietary off-the-shelf technologies to develop novel donor-derived cell-based allogeneic immunotherapies for the treatment of various
cancers at affordable cost. We are aligned with the foresight of our partner SunAct to provide affordable no-option cancer therapeutics
that could improve patients' quality of life. We are excited to work with Dr Vijay Patil in our goal to accelerate the therapeutic
application of CytoMed's patented allogeneic gamma delta T-Cells (Patent Number: MY-200528-A; ZL 2018 8 0023646.8; US 11,629,333
B2) in an increasing population of cancer patients in India and around the world."
to the BRCA, CytoMed will provide scientific and technical assistance in the planning and conduct of the Clinical Trial. CytoMed will
also be responsible for the manufacturing of the allogeneic gamma delta T cells as the investigational product. This collaboration leverages
the in-country relationships of both SunAct and Dr Vijay Patil and their familiarity with the laws and regulations and the CDSCO, the
current in-country developments in the field of immunotherapy, access to relevant healthcare personnel, institutions, and facilities,
and the patient population in India.
BRCA has a term of five years.
CytoMed Therapeutics Limited ("CytoMed")
in 2018, CytoMed was spun off from the Agency for Science, Technology and Research (A*STAR), Singapore's leading research and development
agency in the public sector. It is a biopharmaceutical company focused on harnessing its licensed proprietary technologies, namely gamma
delta T cell and gamma delta Natural Killer T cell, to create novel cell-based immunotherapies for the treatment of human cancers. The
development of novel technologies has been inspired by the clinical success of existing CAR-T therapies in treating hematological malignancies,
as well as the current clinical limitations and commercial challenges in extrapolating the CAR-T principle into the treatment of solid
SunAct Cancer Institute Private Limited ("SunAct")
Cancer Institute, Thane, is at the forefront of innovative cancer treatment and research in India. As one of the first centers to introduce
CAR T-cell therapy, SunAct is revolutionizing the landscape of personalized cancer care. Equipped with state-of-the-art technology and
a multidisciplinary team of experts, the institute offers cutting-edge treatments, compassionate care, and access to clinical trials
for various cancers.
groundbreaking therapies to community outreach, SunAct Cancer Institute is dedicated to transforming lives through hope and healing.
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arise after the date hereof.
: Evelyn Tan, Chief Corporate Officer