Full Press Release Details
Therapeutics Announces Publication of Collaborative Research with The University of Texas, MD Anderson Cancer Center, Demonstrating the
Potential of Allogeneic T Cells in Acute Myeloid Leukemia
Singapore - (October 2, 2025) - CytoMed Therapeutics Limited (NASDAQ: GDTC) ("CytoMed" or "Company"),
a Singapore-based clinical stage biopharmaceutical company focused on harnessing its proprietary technologies to develop novel affordable
donor-derived cell-based immunotherapies for the treatment of a broad range of cancers, including both blood and solid tumours, is pleased
to announce the publication of a preclinical study, in a research article entitled "Donor-Derived V 9V 2 T Cells
for Acute Myeloid Leukemia: A Promising "off-the-shelf" Immunotherapy Approach". The study results from this collaborative
research with The University of Texas, MD Anderson Cancer Center (MDACC), are suggesting the promising potential of CytoMed's allogeneic
T cell therapy (CTM-GDT) for treating acute myeloid leukemia (AML). This collaboration with MDACC is under a previously
announced research agreement in May 2023. The research article is now publicly and freely online at Donor-Derived V 9V 2
T Cells for Acute Myeloid Leukemia: A Promising "Off-the-Shelf" Immunotherapy Approach.
findings provide the rationale for further clinical study of allogeneic donor-derived T cells in treating AML as well
as other cancers. It will facilitate our endeavour to advance our next T cell-based product into clinical trial after
our leading product CAR- T cells (CTM-N2D), which is currently undergoing a Phase 1 clinical trial in Singapore."
said Dr. Zeng Jieming, M.D., Ph.D., Chief Scientific and Medical Officer of CytoMed and co-author of the paper.
Peter Choo, Chairman of CytoMed commented, "This research provides more evidence for applying allogeneic T cells
to hematologic malignancies and we are planning to move into clinical trials in Southeast Asia and bring novel immunotherapy options
to patients with limited treatment alternatives."
CytoMed Therapeutics Limited (CytoMed)
in 2018, CytoMed was spun off from the Agency for Science, Technology and Research (A*STAR), Singapore's leading research and development
agency in the public sector. CytoMed is a clinical stage biopharmaceutical company focused on harnessing its licensed proprietary technologies,
namely gamma delta T cell and iPSC-derived gamma delta Natural Killer T cell, to create novel cell-based allogeneic immunotherapies for
the treatment of various human cancers. The development of novel technologies has been inspired by the clinical success of existing CAR-T
therapies in treating haematological malignancies, as well as the current clinical limitations and commercial challenges in extrapolating
("X") @CytomedSG, on LinkedIn, and Facebook.
press release contains forward-looking statements as defined by the Private Securities Litigation Reform Act of 1995. Forward-looking
statements include statements concerning plans, objectives, goals, strategies, future events or performance, and underlying assumptions
and other statements that are other than statements of historical facts. When the Company uses words such as "may, "will,
"intend," "should," "believe," "expect," "anticipate," "project,"
"estimate" or similar expressions that do not relate solely to historical matters, it is making forward-looking statements.
Forward-looking statements are not guarantees of future performance and involve risks and uncertainties that may cause the actual results
to differ materially from the Company's expectations discussed in the forward-looking statements. These statements are subject
to uncertainties and risks including, but not limited to, the following: the Company's plans to develop and commercialize its product
candidates; the initiation, timing, progress and results of the Company's current and future pre-clinical studies and clinical
trials and the Company's R&D programs; the Company's estimates regarding expenses, future revenue, capital requirements
and needs for additional financing; the Company's ability to successfully acquire or obtain licenses for additional product candidates
on reasonable terms; the Company's ability to establish and maintain collaborations and/or obtain additional funding and assumptions
underlying or related to any of the foregoing and other risks contained in reports filed by the Company with the SEC. For these reasons,
among others, investors are cautioned not to place undue reliance upon any forward-looking statements in this press release. Additional
factors are discussed in the Company's filings with the SEC, which are available for review at www.sec.gov. The Company undertakes
no obligation to publicly revise these forward-looking statements to reflect events or circumstances that arise after the date
Therapeutics Limited
: Evelyn Tan, Chief Corporate Officer