Full Press Release Details
Disrupting Convention in Women's Health Through Continuous Innovation February 2024 Corporate
Forward-Looking Statements This Presentation contains "forward-looking statements" within the
meaning of the Private Securities Litigation Reform Act of 1995 relating to our business, operations and financial conditions, including but not limited to current beliefs, expectations and assumptions regarding the future of our business,
future plans and strategies, results of clinical trials and other future conditions. Words such as, but not limited to, "anticipate", "believe", "could", "estimate", "expect", "intend", "may", "plan", "potential", "predict", "project",
"should", "will", "would" or the negative of those terms, and similar expressions that convey uncertainty of future events or outcomes, identify forward-looking statements. These forward-looking statements reflect management's beliefs and
views with respect to future events and are based on estimates and assumptions as of the date of this Presentation and are subject to risks and uncertainties. Moreover, the Company operates in a very competitive and rapidly changing
environment. New risks emerge from time to time. It is not possible for management to predict all risks, nor can the Company assess the impact of all factors on its business or the extent to which any factor, or combination of factors, may
cause actual results to differ materially from those contained in any forward-looking statements we may make. Given these uncertainties, you should not place undue reliance on these forward-looking statements. The Company qualifies all of the
forward-looking statements in this Presentation by these cautionary statements. Except as required by law, the Company undertakes no obligation to publicly update any forward-looking statements, whether as a result of new information, future
events or otherwise. Statements contained herein are made as of the date of this Presentation unless stated otherwise, and neither this Presentation, nor any sale of securities, shall under any circumstances create an implication that the
information contained herein is correct as of any time after such date or that the information will be updated or revisited to reflect information that subsequently becomes available or changes occurring after that date hereof. Certain
information contained in this Presentation relates to or is based on statistical and other industry and market data obtained from independent industry publications and research, surveys and studies conducted by independent third parties as
well as the Company's own estimates. The market data used in this Presentation involves a number of assumptions and limitations, and you are cautioned not to give undue weight to such data. Industry publications and third-party research,
surveys and studies generally indicate that their information has been obtained from sources believed to be reliable, although they do not guarantee the accuracy or completeness of such information. The Company's estimates of the total
addressable market of the patient population with the potential to benefit from treatment with any product candidates the Company may develop, our ability to commercialize our product candidates, or the effect of delays in commercializing
include several key assumptions based on its industry knowledge, industry publications and third-party research, which may be based on a small sample size and may fail to accurately reflect the addressable patient population. While the
Company believes that its internal assumptions are reasonable, no independent source has verified such assumptions. This Presentation contains trademarks, trade names, or service marks belonging to other entities. The Company does not intend
the use or display of other parties' trade names, trademarks or service marks to imply a relationship with, or endorsement or sponsorship of, or by these other parties. 2
Femasys' Mission has Remained the Same Despite Significant Market Changes Who We Are Financial
Information Femasys is focused on meeting significant unmet needs for women worldwide with a broad portfolio of in-office, accessible solutions. Femasys is poised to navigate the ever-changing landscape of women's health by enabling choice
and empowering women. Headquarters: Suwanee, GA Nasdaq: FEMY (IPO June 2021) Market Cap: $35M (as of 02/27/24) Cash: $23M (as of 11/15/23) 3
Investment Highlights Differentiator 4 Develop disruptive approaches for women's health
Address multi-billion-dollar global market opportunities Limited competition with clear reimbursement path Improved patient care and health economics Intellectual property portfolio with >150 patents globally Cash runway into Q2
2025 Woman-founded and led, experienced leadership team Commercial-readiness with in-house CMC and device manufacturing Global regulatory approvals, including the U.S., Japan, and Canada Mission Foundation
Key Leadership Brian Drumheller VP, Quality 30+ years of experience Dan Currie Chief
Operating Officer 30+ years of experience Jeremy Sipos VP, Research & Development 20+ years of experience Christine Thomas SVP, Regulatory & Clinical 20+ years of experience Chris Johansen VP, Manufacturing 20+ years of
experience James Liu, MD Chief Medical Officer 40+ years of experience Mary An Merchant, JD, PhD VP Counsel, Intellectual Property 25+ years of experience Dov Elefant Chief Financial Officer 25+ years of experience 5 Kathy
Lee-Sepsick President, CEO, Founder 25+ years of experience Richard Spector Chief Commercial Officer 25+ years of experience
FemBloc Product Candidate Research Preclinical Stage ISafety Stage IIValidation Stage
IIIPivotal Our Technologies Provide a Continuum of Care 6 In-office, minimally invasive solutions that share delivery platforms. Commercially Available Products Commercially Available Products FemaSeed Treatment Intratubal
Insemination FemVue Diagnostic Contrast-Generating Device FemCath Diagnostic Selective Delivery Catheter FemCerv Diagnostic Endocervical Tissue Sampler Permanent Birth Control Clinical Trial
FemaSeed Intratubal Artificial Insemination 7 Innovative first-line infertility treatment
designed to deliver sperm directly where conception occurs First in-office ultrasound evaluation of fallopian tubes Infertility Focused Portfolio FemVue Tubal Diagnosis with Ultrasound FDA-Cleared in U.S. and Approved in Canada
No New Affordable Options for Infertility in
Decades 8 https://www.cdc.gov/nchs/nsfg/key_statistics/i-keystat.htm Kumar N, et al. (2015) Levine H. et al. (2023) Centers for Disease Control and Prevention (2019) Chandra A, et al. (2014) Key Trends: 43 U.S. states have recorded
lowest fertility rate in last three decades4 9.14 million women have received infertility services at some time in their lives5 >10M women struggle with infertility1 ~50% due to male factor2 Sperm counts worldwide have declined by
4.3M seek evaluation only FemaSeed and FemVue Advanced as Less Costly
Options 9 Diagnosis Discussion Drugs IUI IVF PATIENT JOURNEY *Centers for Disease Control and Prevention. 2019 Assisted Reproductive Technology Fertility Clinic and National Summary Report. US Dept of Health and Human Services;
2021. ~200k cycles/ year in U.S. ~1 M cycles/ year in U.S.* ~ 90% couples with male factor infertility For female, multiple invasive procedures, medical risks and impact on quality of life.
FemaSeed and FemVue Advanced as Less Costly
Options 10 Diagnosis Discussion Drugs IUI IVF FemVue FemaSeed PATIENT JOURNEY Safe Time-saving Affordable Convenient ~200k cycles/ year in U.S. ~1 M cycles/ year in U.S.* *Centers for Disease Control and Prevention. 2019
Assisted Reproductive Technology Fertility Clinic and National Summary Report. US Dept of Health and Human Services; 2021.
Femasys' Product Portfolio from Diagnosis to Treatment 11 First In-office, Ultrasound Approach
for Fallopian Tube Evaluation Video will open in browser window. Allows for selective evaluation when needed Contrast generated allows for diagnosis of tube FemVue intended population: Baseline diagnostic test for infertility (blocked
tubes are a silent factor affecting 1 in 3 infertile women) Open fallopian tube(s) should be established prior to any infertility treatment.
Femasys' Product Portfolio from Diagnosis to Treatment 12 Video will open in browser
window. Video will open in browser window. Delivers sperm to where conception occurs First Intratubal Insemination Approach without Catheterization FemaSeed intended population: Infertile women/ couples Patients desiring insemination,
including same sex couples & single women FemaSeed requires at least one open fallopian tube (FemVue can be performed first to confirm)
13 FemaSeed Overcomes the Last Barrier to Natural Fertilization Sperm must travel from vagina to
the fallopian tube where conception occurs. Vagina Cervix Uterus FemaSeed IUI Fallopian Tube - Reproductive Endocrinologist HCP* - Reproductive Endocrinologist HCP* - Reproductive Endocrinologist HCP* FemaSeed Advantages from
Market Research *Femasys proprietary market research (100 reproductive endocrinologists). It's angle toward the opening (ostia) is the most critical finding that I am impressed with that allows sperm to be the closest to the egg. It's an
interesting concept for women who have unilateral disease [blocked tube]. " Delivery to fallopian tube makes sense with low count [sperm] cases to improve efficacy. " " " " " 92% of Survey Respondents had favorable impression of
14 "Being aware that there are many reasons why women have issues conceiving, FemVue is one easy
procedure that can assist in finding out why it may have been difficult. As such, I highly recommend any woman who has tried for months or years to conceive to get the FemVue procedure. It is a procedure that will get you immediate results
for you and your doctor to discuss the next steps of making your dreams come true." "After a month of completing successful medical procedures including FemVue, my husband and I conceived our first child." "For more than 20 years, current
approaches to infertility treatment have been limited during the initial stage of therapeutic care, but with the advancement of FemaSeed, we believe a next generation intrauterine procedure may have the opportunity to truly change this
traditional paradigm." The Unmet Need in Infertility: Compelling Testimonials - Michael Glassner, MD Founding Partner and Medical Director of Main Line Fertility & Reproductive Medicine FemaSeed Physician Testimonial FemVue Patient
Commercialization Strategy in U.S. 15 Initial Focus ~1,700 Infertility
Specialists ~40,000 Gynecologists Limited Market Release Focused regions and targeted audience Focused sales and marketing efforts Monitoring, evaluation and iterative improvement Expanded Market Release Wider distribution and
geographical expansion Targeted marketing and sales strategies Education and training Expanded product offerings Customer support, feedback collection and monitoring market performance Expanded Focus
FemaSeed Priced to Support First-Line Treatment Option 16 IUI Intrauterine
Insemination FemaSeed $500-$4,0001 total per cycle including ultrasound monitoring, and optional ovulation drugs2 + device per cycle above IUI cost Average Total
Cost 1https://www.fertilityiq.com/iui-or-artificial-insemination/the-cost-of-iui 2Parenthood, Planned. "What Is Intrauterine Insemination (IUI)?" Planned Parenthood,
https://www.plannedparenthood.org/learn/pregnancy/fertility-treatments/what-iui. 3Ravitsky, et al. The forgotten men: rising rates of male infertility urgently require new approaches for its prevention, diagnosis and treatment. Biology of
Reproduction, 2019, 101(5), 872-874. IVF/ ICSI In vitro fertilization / intracytoplasmic sperm injection $30,000 total per cycle, including ultrasound monitoring, ovulation drugs, egg extraction and freezing3 Population If
insurance, covered under IUI codes (service, sperm washing) Insurance with positive coverage policy typically covers 3-6 cycles Required prior to IVF/ ICSI in many coverage policies Infertile Women/ Couples Seeking Treatment Subset of
Infertile (After 1-3 IUI cycles or as indicated) Intratubal Insemination (FDA cleared as form of an IUI) Reimbursement 14/20 covered states that have fertility insurance coverage, include IVF
FemaSeed has Significant Potential Revenue Opportunity 17 Market Expansion opportunity $2B 1
million* IUI cycles/ yr Addressable market opportunity 4.8 millionwomen seek evaluation & treatment Market immediate addressable Future patients *Centers for Disease Control and Prevention. 2019 Assisted Reproductive Technology
Fertility Clinic and National Summary Report. US Dept of Health and Human Services; 2021 4.3 millionseek evaluation only
FemBloc Permanent Birth Control 18 First and only non-surgical, in-office, permanent birth
control option In late-stage clinical development with on-going multi-center pivotal trial (FINALE) Potential to be the safest and most natural approach at substantially less cost than the long-standing surgical alternative In-Office
Sterilization Lead Product Candidate
>100 Years of Stagnant Innovation for Permanent Birth Control $20B total market
expansion 19 *Frattarelli 2007 >13M women no longer intend to have children >12M use non-permanent birth control long-term $2B annual market opportunity 800,000 women choose surgical tubal ligation as a form of permanent birth
FemBloc: Expected Competitive Advantages Permanent Birth Control Temporary FemBloc Surgical
Sterilization (94% effective*) Essure No longer marketed (95% effective*) IUD Permanent Office Procedure Some No Special Capital Equipment No Anesthesia No Permanent Implant (coil/ clip) No Surgery
(risks/ cost) No Hormones One-Time Treatment Cost Multiple IUDs Worldwide Applicability Varies 20 *Fertility and Sterility, 2022
No Permanent Implant - Scar Tissue Closes Tubal Lumen FemBloc Treatments FemBloc: In-Office
Procedure followed by Ultrasound Confirmation Test Balloon at tubal opening without cannulation Biopolymer is designed to be expelled within 3 months Biopolymer solidifies 21 Video will open in browser window. Biopolymer
degrades Confirmation Test (to ensure success) Video will open in browser window.
Completed Earlier FemBloc Supportive Studies (N=321) Stage I: Safety (N=183); IDE
approved FemBloc Clinical Studies for Pre-Market Approval (PMA) 22 Stage III: FINALE Pivotal Clinical Trial Trial Design (IDE approved June 2023; currently enrolling) Prospective, multi-center, open-label, single-arm study Roll-in study
design (50 subjects in part A for safety) Endpoints: Primary: pregnancy rate at 1-year after using FemBloc (N=401) Secondary: safety and various in-office assessments Additional Analysis: 2-5 years post-market for safety Interim
analysis: after 300 women have used FemBloc for 1-year Selection of Confirmation Test for Pivotal Stage II: Validation (N=45); IDE approved Early Clinical (N=93) Long-Term Safety with No Serious AEs Reported Evaluated Delivery &
FemBloc Safety Profile (N = 228 subjects from Stage I & II; 5-year follow-up
on-going) 23 Other Key Findings: Investigator Rating: 96% extremely or very satisfied with FemBloc Most common AEs: 59% bleeding/ spotting 55% pain/ cramps Mean pain score per visual analog scale (0-10): 4.6 FemBloc 3.4
confirmation test 61% 8% 16% 3% 0.5% 5% 4% 0.5% 0.8% No SAEs 91% AEs related to device/procedure occurred within 7 days of procedure FemBloc Treatment Timing of AEs
FemBloc Improves Health Economics Permanent One-Time Cost Breakdown Pre-Op
$6,000* Facility Anesthesia Post-Op Cost of FemBloc System Anesthesia Physician / Practice FemBloc estimate < cost of Tubal Ligation Physician In-office procedure expands practice services Can perform multiple procedures in
same room Quick to perform; ease of room turnover Patient resumes normal activities Expect 3 reimbursable visits FemBloc Efficiencies *Planned Parenthood 2019, https://www.plannedparenthood.org/learn/birth-control;Doximity 2019; U.S.
Bureau of Labor Statistics, 2019. 24 NO COST TO PATIENT (covered under Affordable Care Act)
Upcoming Anticipated Milestones Near term expected valuation inflection points creating accretive
value for investors. 25 Q1 Q2 Q3 Q4 Top line data for FemaSeed pivotal clinical trial (LOCAL) Initial commercial team on-boarded Limited market release of infertility product portfolio in North America Achieve CE mark for
infertility product portfolio Expand market release of infertility product portfolio to additional regions in North America Femasys Milestones
Investment Highlights Differentiator 26 Develop disruptive approaches for women's health
Address multi-billion-dollar global market opportunities Limited competition with clear reimbursement path Improved patient care and health economics Intellectual property portfolio with >150 patents globally Cash runway into Q2
2025 Woman-founded and led, experienced leadership team Commercial-readiness with in-house CMC and device manufacturing Global regulatory approvals, including the U.S., Japan, and Canada Mission Foundation
Disrupting Convention in Women's Health Through Continuous Innovation February 2024 Corporate
Presentation Investors: IR@femasys.com Contact: Media: Media@femasys.com 27 03333 R08