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VIDEO: David Kirn, Co-Founder & CEO, 4DMT, provides an update on two candidates for retinal diseases

Key Takeaway: David Kirn, CEO of 4D Molecular Therapeutics, provided updates on two retinal disease candidates during a recent summit. The PRISM phase 2 trial for 4D-150 showed promising safety and efficacy results, including reduced need for anti-VEGF injections in wet AMD patients. The company has also filed for an investigational new drug application for 4D-175 targeting geographic atrophy and plans to initiate phase 3 trials in Q1 next year.
Price reaction · baseline $20.99 (2024-06-28 close) · hit pre-market · clean, no other FDMT news in the window
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Market Sentiment Analysis

POSITIVE FACTORS

  • 4D-150 shows positive safety and efficacy results.
  • Reduction in annualized anti-VEGF injections for wet AMD patients.
  • Initiation of phase 3 trials planned for Q1 next year.

BiopharmaWatch Analysis

From our catalyst data and publicly available data · not financial advice
Best trade, last catalyst
+128%
120-day peak, hindsight
Typical move
11.2%
average across 9 past catalysts
Cash runway
~18 mo
Low dilution risk
Lead asset
4D-150 IVT
Phase 3 · Macular Neovascularization Secondary to Age-Related Macular Degeneration

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PARK CITY, Utah — In this Healio Video Perspective from Clinical Trials at the Summit, David Kirn , MD, of 4D Molecular Therapeutics provides an update on two candidates for retinal diseases.
4D-150 demonstrated positive safety, retinal anatomy and durability results, as well as a reduction in the need for annualized anti-VEGF injections in patients with wet age-related macular degeneration, in the PRISM phase 2 clinical trial , he said.
The company has also filed an investigational new drug application for 4D-175 for the treatment of geographic atrophy.
“The next step in our development of these programs is to initiate phase 3 in Q1 of next year in wet AMD with 4D-150,” Kirn said. “We’ll also report out our first [diabetic macular edema] data in Q4 of this year in high-need DME patients.”

Sources/Disclosures

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Healio Interviews
Disclosures: Kirn reports being co-founder and CEO of 4D Molecular Therapeutics.
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Frequently Asked Questions

What updates did David Kirn provide on 4DMT's candidates?

David Kirn updated on 4D-150's positive phase 2 results and the filing for 4D-175.

What were the results of the PRISM phase 2 trial?

The PRISM phase 2 trial showed positive safety and efficacy results for 4D-150.

When will phase 3 trials for 4D-150 begin?

Phase 3 trials for 4D-150 are set to begin in Q1 of next year.

What is the focus of the investigational new drug application?

The application focuses on 4D-175 for treating geographic atrophy.

Last updated: Jul 1, 2024