Full Press Release Details
Evaxion unveils proprietary genetic adjuvant
technology to boost the effect of DNA and mRNA vaccines
COPENHAGEN, Denmark,
May 25, 2023 (GLOBE NEWSWIRE) -- Evaxion Biotech A/S (NASDAQ: EVAX) ("Evaxion" or the "Company"), a
clinical-stage biotechnology company specializing in the discovery and development of AI-powered immunotherapies, today unveils the technology
behind its novel, proprietary genetic adjuvant developed to enhance the effectiveness of DNA and mRNA vaccines for infectious diseases
the adjuvant program were presented at Evaxion's live stream R&D Day, May 25, 2023.
to present this novel genetic adjuvant technology to the global scientific community. It boosts Evaxion s own DNA technology and
has the potential to improve the effect of virtually any vaccine. We foresee a great market potential in that this technology appears
to be highly effective in both DNA and mRNA based vaccines against cancer as well as infectious diseases." said Per Norl n,
novel genetic adjuvant carries the code for CCL19, a molecule known to attract immune cells, notably antigen presenting cells, and can
be encoded into either DNA or mRNA vaccines with the aim of boosting the immune response.
that the genetic adjuvant technology boosts the antitumor effect in preclinical tumor models, and induces neutralizing antibodies and
T-cell responses against both viral and bacterial antigens:
Delivery of DNA or mRNA cancer neoantigen vaccines induced strong neoantigen-specific T-cell responses and complete antitumor responses
of a COVID-19 T-cell epitope DNA vaccine resulted in a strong and specific T-cell response and protected against a lethal dose of
the virus (90% survival)
of a Neisseria Gonorrhoeae antigen DNA vaccine induced high antibody titers and specific T-cell responses towards the
continues, "By encoding the immune-stimulating molecule CCL19 into either DNA or mRNA vaccines, we have demonstrated
significant enhancement of the vaccines effectiveness. We believe that this advancement holds immense potential for vaccine development,
as it boosts both B cell and T cell immune responses, making it applicable to a wide range of vaccines. Building on the encouraging preclinical
results, the next step is to validate the technology in patients."
bring the genetic adjuvant technology into clinical trials later this year as part of the personalized cancer immunotherapy program EVX-03.
Investors section of Evaxion's website to access a replay of the R&D Day presentations.
A/S is a pioneering company developing AI-powered immunotherapies. Evaxion's proprietary and scalable AI technologies decode the
human immune system to discover and develop novel immunotherapies for cancer, bacterial diseases, and viral infections. Evaxion has a
broad pipeline of candidates, including three personalized cancer immunotherapies. It is located in H rsholm, Denmark, with 50
employees listed on the Nasdaq New York stock exchange. For more information, please visit www.evaxion-biotech.com.
For more information:
Per Norl n Chief Executive Officer
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including, but not limited to, risks related to: our financial condition and need for additional capital; our development work; cost and
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our most recent Annual Report on Form 20-F and other filings with the U.S. Securities and Exchange Commission (SEC), which are available
at www.sec.gov. We do not assume any obligation to update any forward-looking statements except