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Eton Pharmaceuticals Receives Complete Response Letter (CRL) for Dehydrated Alcohol Injection

Key Takeaway: Eton Pharmaceuticals has received a Complete Response Letter (CRL) from the FDA regarding its New Drug Application for dehydrated alcohol injection aimed at treating methanol poisoning. The concerns raised by the FDA primarily revolve around Chemistry Manufacturing and Controls (CMC). Despite this setback, Eton's CEO expressed confidence that the issues are addressable and emphasized the company's ongoing strength in commercial business and product revenue growth. Eton is also expanding its product portfolio with the recent addition of Betaine Anhydrous for Oral Solution.

Market Sentiment Analysis

POSITIVE FACTORS

  • The company believes it can address the issues raised by the FDA.
  • Eton Pharmaceuticals maintains a strong commercial business.
  • The company anticipates reporting record product revenue for Q2 2023.

CONCERNS & RISKS

  • The FDA issued a Complete Response Letter (CRL) for the New Drug Application.
  • The issues raised in the CRL relate primarily to Chemistry Manufacturing and Controls (CMC).

Full Press Release Details

Pharmaceuticals Receives Complete Response Letter (CRL) for Dehydrated Alcohol Injection
PARK, Ill., June 28, 2023 (GLOBE NEWSWIRE) - Eton Pharmaceuticals, Inc (Nasdaq: ETON), an innovative pharmaceutical company focused
on developing and commercializing treatments for rare diseases, today announced that the U.S. Food and Drug Administration (FDA) issued
a Complete Response Letter (CRL) in response to its New Drug Application (NDA) for dehydrated alcohol injection for the treatment
of methanol poisoning. The issues raised in the CRL relate primarily to Chemistry Manufacturing and Controls (CMC). The Company
believes all issues in the CRL are addressable and will develop a comprehensive action plan to address the FDA's
we are disappointed with the FDA's decision, our commercial business remains strong, and we are pleased that our momentum in product
revenue growth has continued. We expect to once again report record product revenue in the second quarter of 2023. With the recent addition
of Betaine Anhydrous for Oral Solution to our commercial product portfolio, we are well positioned for continued sustainable long-term
growth," said Sean Brynjelsen, CEO of Eton Pharmaceuticals.
Eton Pharmaceuticals
Pharmaceuticals, Inc. is an innovative pharmaceutical company focused on developing and commercializing treatments for rare diseases.
The Company currently has three FDA approved products in ALKINDI SPRINKLE , Carglumic Acid tablets, and Betaine Anhydrous for oral
solution, and four late-stage pipeline candidates under development with dehydrated alcohol injection, ZENEO hydrocortisone autoinjector,
ET-400, and ET-600. In addition, the Company receives royalties and is entitled to receive milestone payments
on other products. For more information, please visit our website at www.etonpharma.com.
M. Wilson, In-Site Communications, Inc.
Eton Pharmaceuticals

Frequently Asked Questions

What is the recent development regarding Eton Pharmaceuticals?

Eton Pharmaceuticals received a Complete Response Letter from the FDA for dehydrated alcohol injection.

What does the Complete Response Letter from the FDA indicate?

The CRL indicates issues related to Chemistry Manufacturing and Controls for the drug application.

Does Eton Pharmaceuticals plan to address the issues in the CRL?

Yes, Eton believes all issues are addressable and will create a comprehensive action plan.

How has Eton Pharmaceuticals' commercial business performed?

Despite the CRL, Eton's commercial business remains strong, with expected record revenue.

What products does Eton Pharmaceuticals currently offer?

Eton has three FDA-approved products and four late-stage pipeline candidates under development.

Last updated: Jun 28, 2023