Eton Pharmaceuticals Announces Commercial Availability of Biorphen (phenylephrine HCI) Injection ~ Biorphen is the First and Only Ready-to-Use FDA-Approved Injectable Formulation of Phenylephrine ~ ~ Biorphen is Now Avai

Pharmaceuticals Announces Commercial Availability of Biorphen (phenylephrine HCI) Injection

Biorphen is the First and Only Ready-to-Use FDA-Approved Injectable Formulation of Phenylephrine ~

Biorphen is Now Available for Order Through Major Wholesalers ~

Biorphen is Eton Pharmaceuticals' First Commercially Available Product ~

PARK, Ill., Dec. 2, 2019 (GLOBE NEWSWIRE) - Eton Pharmaceuticals, Inc. (Nasdaq: ETON), a specialty pharmaceutical company

focused on developing and commercializing innovative drug products, today announced that Biorphen , the first and

only FDA-approved ready-to-use formulation of phenylephrine for the treatment of clinically important hypotension resulting primarily

from vasodilation in the setting of anesthesia, is now commercially available. Biorphen is available in a 5mL ampule containing

500mcg of phenylephrine. The product is now available for ordering through wholesalers McKesson, AmerisourceBergen, and Cardinal

Biorphen's approval, we have seen strong interest from both physicians and hospital pharmacy directors and we are excited

to begin supplying the product. The availability of Biorphen reduces the need for hospitals to rely on compounders to provide

unapproved compounded phenylephrine," said Sean Brynjelsen, President and Chief Executive Officer of Eton. "In addition,

Biorphen's three-year shelf life allows hospitals to more easily stock the product in operating rooms, emergency rooms,

and crash carts. We are well prepared for the commercial success of Biorphen with a strong and experienced sales team that is

fully trained and deployed promoting Biorphen to hospitals throughout the US."

teams at Eton and Sintetica have worked closely together to ensure that Biorphen is ready for launch and to assuredly supply the

United States healthcare system from day one with the first and only FDA-approved ready-to-use injectable formulation of phenylephrine,"

said Pasquale Mitidieri, Corporate Director of Sintetica's Global Division.

estimates the total addressable market for Biorphen is more than 20 million units annually. In tandem with its manufacturing partner

Sintetica, Eton expects to have the capacity to supply this market as necessary. Eton's sales force currently includes a

team of field representatives and inside sales representatives that will be initially targeting the institutions with the highest

phenylephrine usage.

ordering and product information visit www.Biorphen.com.

(phenylephrine HCI) Injection is the first and only FDA-approved ready-to-use formulation of phenylephrine for treating

clinically important hypotension resulting primarily from vasodilation in the setting of anesthesia. Ready-to-use Biorphen can

be standardized and stocked in operating rooms, emergency departments and intensive care units, as well as in crash carts throughout

the hospital. With a three-year shelf life, Biorphen can be stocked throughout hospitals without frequent restocking.

injection is an alpha-1 adrenergic receptor agonist indicated for the treatment of clinically important hypotension resulting

primarily from vasodilation in the setting of anesthesia.

and Precautions: BIORPHEN can precipitate angina in patients with severe arteriosclerosis or history of angina, exacerbate

underlying heart failure, and increase pulmonary arterial pressure. Can also cause excessive peripheral and visceral vasoconstriction

and ischemia to vital organs. Extravasation during intravenous administration may cause necrosis or sloughing of tissue. Can cause

severe bradycardia and decreased cardiac output, renal toxicity, augmented pressor effect in patients with autonomic dysfunction

and pressor effect with concomitant oxytocic drugs.

common adverse reactions during treatment: nausea, vomiting, and headache.

report SUSPECTED ADVERSE REACTIONS, contact Eton Pharmaceuticals, Inc. at 1-888-450-0568 or FDA at 1-800-FDA-1088.

of BIORPHEN (phenylephrine hydrochloride) can cause a rapid rise in blood pressure. Symptoms of overdose include headache, vomiting,

hypertension, reflex bradycardia, a sensation of fullness in the head, tingling of the extremities, and cardiac arrhythmias including

ventricular extrasystoles and ventricular tachycardia.

Eton Pharmaceuticals, Inc.

Pharmaceuticals, Inc. is a specialty pharmaceutical company focused on developing and commercializing innovative products utilizing

the FDA's 505(b)(2) regulatory pathway. Eton is primarily focused on liquid dosage forms including injectables, oral liquids

and ophthalmics. Eton has a diversified pipeline of high-value product candidates in various stages of development and therapeutic

areas, including multiple product candidates currently under review by the FDA.

contained in this press release regarding matters that are not historical facts are "forward-looking statements" within

the meaning of the Private Securities Litigation Reform Act of 1995, including statements associated with the expected ability

of Eton to undertake certain activities and accomplish certain goals and objectives. These statements include but are not limited

to statements regarding Eton's business strategy, Eton's plans to develop and commercialize its product candidates,

the safety and efficacy of Eton's product candidates, Eton's plans and expected timing with respect to regulatory

filings and approvals, and the size and growth potential of the markets for Eton's product candidates. Because such statements

are subject to risks and uncertainties, actual results may differ materially from those expressed or implied by such forward-looking

statements. Words such as "believes," "anticipates," "plans," "expects," "intends,"

"will," "goal," "potential" and similar expressions are intended to identify forward-looking

statements. These forward-looking statements are based upon Eton's current expectations and involve assumptions that may

never materialize or may prove to be incorrect. Actual results and the timing of events could differ materially from those anticipated

in such forward-looking statements as a result of various risks and uncertainties, which include, without limitation, risks associated

with the process of discovering, developing and commercializing drugs that are safe and effective for use as human therapeutics,

and in the endeavor of building a business around such drugs. These and other risks concerning Eton's development programs

and financial position are described in additional detail in Eton's filings with the Securities and Exchange Commission.

All forward-looking statements contained in this press release speak only as of the date on which they were made. Eton undertakes

no obligation to update such statements to reflect events that occur or circumstances that exist after the date on which they