Ernexa Therapeutics Provides Update on Operational Excellence and Performance

CAMBRIDGE, Mass., Sept. 10, 2025 (GLOBE NEWSWIRE) --Ernexa Therapeutics(Nasdaq: ERNA), developing innovative cell therapies for the treatment of advanced cancer and autoimmune disease, today provided an update on its operational excellence and performance for the first half of 2025. The company reported its financial results in its Quarterly Report on Form 10-Q for the period ending on June 30, 2025, filed with the Securities and Exchange Commission on August 13, 2025. The substantial year-over-year improvements were driven by focused execution and cost discipline as the company advances its lead cell therapy product, ERNA-101 for ovarian cancer, toward clinical studies, as well as further progressing ERNA-201 for autoimmune disease.

Ernexa is a stronger company today due to the following operational milestones achieved during the first half of this year:

“These first half results reflect the discipline we’ve brought to the business. We are operating leaner, prioritizing the programs that matter the most, and positioning Ernexa to execute and thrive,” said Sanjeev Luther, President and CEO of Ernexa Therapeutics. “With our operating expenses down by 51% compared to last year, as well as a streamlined cost structure, we believe we have the right foundation to advance our cell therapies toward the clinical stage and continue building a durable company that can deliver off-the-shelf cell therapies to patients who need better options.”

Ernexa is advancing a best-in-class approach using synthetic, allogeneic induced mesenchymal stem cells (iMSCs) to provide a scalable, off-the-shelf treatment without needing patient-specific cell harvesting. The company’s two highly innovative cell therapy products, focused on targeting ovarian cancer and autoimmune disease, are currently advancing through preclinical stages.

Ernexa Therapeutics (NASDAQ: ERNA) is developing innovative cell therapies for the treatment of advanced cancer and autoimmune disease. Ernexa’s core technology focuses on engineering induced pluripotent stem cells (iPSCs) and transforming them into induced mesenchymal stem cells (iMSCs). Ernexa’s allogeneic synthetic iMSCs provide a scalable, off-the-shelf treatment, without needing patient-specific cell harvesting.

ERNA-101 is the company’s lead cell therapy product, designed to activate and regulate the immune system's response to recognize and attack cancer cells. ERNA-201 is a cell therapy product designed to target inflammation and treat autoimmune disease. The company’s initial focus is to develop ERNA-101 for the treatment of ovarian cancer.

This press release contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, which are intended to be covered by the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. Forward-looking statements, in some cases, can be identified by terms such as "believe," "may," "will," "estimate," "continue," "anticipate," "design," "intend," "expect," "could," "plan," "potential," "predict," "seek," "should," "would," "contemplate," "project," "target," "objective," or the negative version of these words and similar expressions. Forward-looking statements involve known and unknown risks, uncertainties and other factors that may cause Ernexa's actual results, performance or achievements to be materially different from future results, performance or achievements expressed or implied by the forward-looking statements in this press release, including, without limitation, risks and uncertainties related to: progress and possible outcomes of the Company’s lead research project, ERNA-101, and future research projects. Forward-looking statements are based upon Ernexa's current expectations and involve assumptions that may never materialize or may prove to be incorrect. All forward-looking statements are expressly qualified in their entirety by these cautionary statements. For a detailed description of Ernexa's risks and uncertainties, you are encouraged to review its documents filed with the SEC including its recent filings on Form 8-K, Form 10-K and Form 10-Q. You are cautioned not to place undue reliance on forward-looking statements, which speak only as of the date on which they were made. Ernexa does not undertake any obligation to update the forward-looking statements contained herein to reflect events that occur or circumstances that exist after the date hereof, except as required by applicable law.