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FORM 51-102F3 MATERIAL CHANGE REPORT Item 1: Name and Address of Company Eupraxia Pharmaceuticals Inc. (the " Company ") 201-2067 Cadboro Bay Rd. Victoria, British Columbia Canada, V8R 5G4 Item 2: Date of Material Change

Key Takeaway: Eupraxia Pharmaceuticals Inc. has successfully closed a public offering of 14,636,363 common shares at a price of $5.50 per share, generating gross proceeds of about $80.5 million. The company plans to allocate the net proceeds primarily for ongoing preclinical studies and clinical trials, as well as expanding its product pipeline. This financing aims to support regulatory submissions, manufacturing scale-up, and general corporate purposes.

Market Sentiment Analysis

POSITIVE FACTORS

  • Eupraxia Pharmaceuticals successfully closed a public offering.
  • The offering raised approximately $80.5 million for the company.
  • The funds will support the advancement of the company's product pipeline.

Full Press Release Details

MATERIAL CHANGE REPORT
Eupraxia Pharmaceuticals Inc. (the "Company")
201-2067 Cadboro Bay Rd.
Victoria, British Columbia
A news release announcing the material change was issued on September 24, 2025 through Globe Newswire and a copy was subsequently filed
On September 24, 2025, the Company announced that it closed its previously announced public offering (the "Offering")
of 14,636,363 common shares of the Company (the "Common Shares"), which includes the issuance of 1,909,090 Common Shares upon full exercise of the option to purchase additional shares granted to the underwriters, at a price to the
public of US$5.50 per Common Share for gross proceeds of approximately US$80.5 million, before deducting the underwriting commissions and estimated expenses incurred in connection with the Offering.
On September 24, 2025, the Company announced that it closed the Offering of 14,636,363 Common Shares, which includes the issuance of
1,909,090 Common Shares upon full exercise of the option to purchase additional shares granted to the underwriters, at a price to the public of US$5.50 per Common Share for gross proceeds of approximately US$80.5 million, before deducting the
underwriting commissions and estimated expenses incurred in connection with the Offering.
Cantor Fitzgerald & Co. and LifeSci
Capital LLC acted as joint book-running managers for the Offering. Bloom Burton Securities Inc. also acted as co-manager for the Offering.
The Company intends to use the net proceeds from the Offering primarily for the continued advancement of its product pipeline, including the
completion of ongoing preclinical studies and clinical trials, regulatory submissions, and associated commercial preparation and manufacturing scale-up activities. A portion of the proceeds will also be
allocated to research and development of additional pipeline candidates, business development initiatives, and general corporate purposes, which may include but are not limited to employee salaries, working capital, leases for facilities,
administrative expenses, and capital expenditures. The Company may also use a portion of the proceeds to expand its intellectual property portfolio and strengthen its corporate infrastructure to support future growth.
The Offering was made pursuant to a U.S. registration statement on Form F-10, declared effective by the U.S. Securities and Exchange Commission (the "SEC") on February 7, 2024, and the Company's existing Canadian short form base shelf prospectus, (the
"Base Prospectus") dated February 5, 2024. A preliminary prospectus supplement and a final prospectus supplement (the "Supplement") relating to and describing the terms of the Offering were filed with the
securities commissions in all of the provinces and territories of Canada, except Quebec, and with the SEC in the United States. The Supplement and accompanying Base Prospectus contain important detailed information about the Offering.
The Supplement and accompanying Base Prospectus can be found on SEDAR+ at www.sedarplus.ca and on EDGAR at www.sec.gov. Copies of the
Supplement and accompanying Base Prospectus may also be obtained from Cantor Fitzgerald & Co., Attention: Capital Markets, 110 East 59th Street, 6th Floor, New York, New York 10022, or by email at prospectus@cantor.com, from LifeSci Capital
LLC at 1700 Broadway, 40th Floor, New York, New York 10019, or by email at compliance@lifescicapital.com, or from Bloom Burton Securities Inc. at ecm@bloomburton.com.
This material change report shall not constitute an offer to sell or the solicitation of an offer to buy, nor shall there be any sale of these
securities in any province, state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of any such province, state or jurisdiction.
For further information, please contact Alex Rothwell, Chief Financial Officer of the Company at 250-590-3968.

Frequently Asked Questions

When did Eupraxia Pharmaceuticals announce its public offering?

The public offering was announced on September 24, 2025.

How many common shares were offered in the Offering?

A total of 14,636,363 common shares were offered.

What was the price per common share in the Offering?

The shares were priced at US$5.50 each.

Who managed the public offering for Eupraxia Pharmaceuticals?

Cantor Fitzgerald & Co. and LifeSci Capital LLC managed the offering.

What will Eupraxia use the Offering's net proceeds for?

Proceeds will fund product development, research, and corporate purposes.

Last updated: Sep 24, 2025