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Enveric Biosciences Reports First Quarter 2025 Financial and Corporate Results Corporate, Business and Product Development Highlights: Unveiled EVM401 Series with new U.S. Patent for mescaline derivative compounds Added

Key Takeaway: Enveric Biosciences has provided a corporate update detailing progress made in the first quarter of 2025. Significant milestones include the unveiling of the EVM401 Series with a new U.S. Patent and two newly signed licensing agreements for cannabinoid-COX-2 conjugate compounds. The company reported a net loss of $2.2 million, with ongoing efforts to support the filing of an Investigational New Drug application for EB-003 anticipated by the end of Q1 2026. With promising preclinical results, Enveric aims to target difficult mental health disorders, positioning itself for future clinical advancements.

Market Sentiment Analysis

POSITIVE FACTORS

  • Enveric unveiled the EVM401 Series with a new U.S. Patent for mescaline derivative compounds.
  • The company signed licensing agreements for cannabinoid-COX-2 conjugate compounds, enhancing its product development pipeline.
  • EB-003 has shown encouraging preclinical results with oral bioavailability and brain exposure.

CONCERNS & RISKS

  • The company reported a net loss attributable to stockholders of $2.2 million for Q1 2025.
  • Despite progress, there is no current marketable product, meaning financial sustainability depends on future clinical success.

Full Press Release Details

Biosciences Reports First Quarter 2025 Financial and Corporate Results
Business and Product Development Highlights:
Unveiled EVM401 Series with new U.S. Patent for mescaline derivative compounds
Added to suite of intellectual property for EB-003, a neuroplastogen targeting undertreated mental health indications
Signed two licensing agreements for cannabinoid-COX-2 conjugate compounds, with potential to target joint pathologies, such as osteoarthritis and rheumatoid arthritis
Announced closing of $5 million public offering
Mass., May 14, 2025 - Enveric Biosciences (NASDAQ: ENVB) ("Enveric" or the "Company"), a biotechnology
company dedicated to the development of novel neuroplastogenic small-molecule therapeutics for the treatment of depression, anxiety,
and addiction disorders, today provided a corporate update and reported financial results for the first quarter ended March 31, 2025.
first quarter of 2025 was highlighted by continued progress in the development of EB-003, our neuroplastogenic molecule that is designed
to address difficult-to-treat mental health disorders," said Joseph Tucker, Ph.D., CEO and Director of Enveric. "We continue
to focus our development efforts on the completion of the data package to support filing an Investigational New Drug (IND) application
for EB-003, which we aim to submit to the FDA by the end of the first quarter of 2026."
Tucker said, "Ongoing development of EB-003 is supported by the data accumulated to date, which have demonstrated oral bioavailability
and brain exposure in preclinical studies. Preclinical work has also shown encouraging pharmacology and safety results from in vitro
pharmacology studies."
Tucker added, "Enveric continues to expand the portfolio of intellectual property covering our proprietary technologies, including
the recent receipt of a Notice of Allowance from the USPTO for claims covering EB-003 composition of matter. We also announced the issuance
of a U.S. patent for our EVM401 Series, a collection of mescaline derivative compounds that broadens Enveric's potential to develop
additional neuroplastogenic therapeutics for addiction and neuropsychiatric disorders. Preliminary testing of our EVM401 series and their
metabolites has demonstrated differentiated and encouraging patterns of brain receptor binding and/or activation."
Tucker concluded, "As we look ahead to the remainder of 2025 and beyond, we are confident that Enveric is at the leading edge of
a paradigm shift in the treatment of severe mental health conditions, an area that has seen minimal innovation for decades. We look forward
to bringing our novel technologies to patients in need, while generating value for our shareholders as we capitalize on the substantial
potential of the emerging field of neuroplastogenic therapeutics."
QUARTER AND RECENT UPDATES
Product and Business Development Highlights:
Unveiled EVM401 Series with new U.S. Patent for mescaline derivative compounds, broadening Enveric's pipeline of neuroplastogen candidates for addiction and neuropsychiatric disorders
Added to suite of intellectual property for EB-003, a neuroplastogen targeting undertreated mental health indications
Signed two licensing agreements with Restoration Biologics LLC, for cannabinoid-COX-2 conjugate compounds, with plans to investigate potential to treat joint pathologies, such as osteoarthritis and rheumatoid arthritis, creating the potential for diversified future revenue streams
Announced closing of $5 million public offering
QUARTER FINANCIAL RESULTS
loss attributable to stockholders was $2.2 million for the first quarter ended March 31, 2025, including $0.3 million in net non-cash
expense, with a basic and diluted loss per share of $1.22, as compared to a net loss of $2.5 million, including $0.4 million in net non-cash
income, with a basic and diluted loss per share of $9.21 for the quarter ended March 31, 2024. The Company had cash-on-hand of $4.3 million
for the quarter ended March 31, 2025.
Biosciences (NASDAQ: ENVB) is a biotechnology company dedicated to the development of novel neuroplastogenic small-molecule therapeutics
for the treatment of depression, anxiety, and addiction disorders. Leveraging its unique discovery and development platform, the Psybrary ,
which houses proprietary information on the use and development of existing and novel molecules for specific mental health indications,
Enveric seeks to develop a robust intellectual property portfolio of novel drug candidates. Enveric's lead molecule, EB-003, is
a potential first-in-class neuroplastogen designed to promote neuroplasticity, without inducing hallucinations, in patients suffering
from difficult-to-address mental health disorders. Enveric is focused on advancing EB-003 towards clinical trials for the treatment of
neuropsychiatric disorders while out-licensing other novel, patented Psybrary drug candidates to third-party licensees advancing
non-competitive market strategies for patient care. Enveric is headquartered in Naples, FL with offices in Cambridge, MA and Calgary,
AB Canada. For more information, please visit www.enveric.com.
press release contains forward-looking statements and forward-looking information within the meaning of applicable securities laws. These
statements relate to future events or future performance. All statements other than statements of historical fact may be forward-looking
statements or information. Generally, forward-looking statements and information may be identified by the use of forward-looking terminology
such as "plans," "expects" or "does not expect," "proposes," "budgets," "explores,"
"schedules," "seeks," "estimates," "forecasts," "intends," "anticipates"
or "does not anticipate," or "believes," or variations of such words and phrases, or by the use of words or phrases
which state that certain actions, events or results may, could, should, would, or might occur or be achieved. Forward-looking statements
may include statements regarding beliefs, plans, expectations, or intentions regarding the future and are based on the beliefs of management
as well as assumptions made by and information currently available to management. Actual results could differ materially from those contemplated
by the forward-looking statements as a result of certain factors, including, but not limited to, the ability of Enveric to: finalize
and submit its IND filing to the U.S. Food and Drug Administration; carry out successful clinical programs; achieve the value creation
contemplated by technical developments; avoid delays in planned clinical trials; establish that potential products are efficacious or
safe in preclinical or clinical trials; establish or maintain collaborations for the development of therapeutic candidates; obtain appropriate
or necessary governmental approvals to market potential products; obtain future funding for product development and working capital on
commercially reasonable terms; scale-up manufacture of product candidates; respond to changes in the size and nature of competitors;
hire and retain key executives and scientists; secure and enforce legal rights related to Enveric's products, including patent
protection; identify and pursue alternative routes to capture value from its research and development pipeline assets; continue as a
going concern; and manage its future growth effectively.
discussion of these and other factors, including risks and uncertainties with respect to Enveric, is set forth in Enveric's filings
with the Securities and Exchange Commission, including Enveric's Annual Report on Form 10-K and its Quarterly Reports on Form 10-Q.
Enveric disclaims any intention or obligation to revise any forward-looking statements, whether as a result of new information, future
events or otherwise, except as required by law.
Strategic Advisors, Inc.
Strategic Advisors, Inc.

Frequently Asked Questions

What is the focus of Enveric Biosciences?

Enveric Biosciences develops neuroplastogenic therapies for depression, anxiety, and addiction.

What are the recent developments for EB-003?

EB-003 is a neuroplastogen targeting difficult mental health disorders, with an IND application planned for 2026.

What new patents did Enveric announce?

Enveric received a patent for the EVM401 Series, mescaline derivatives for neuropsych disorders.

How much cash did Enveric have at the end of Q1 2025?

Enveric had $4.3 million in cash on hand as of March 31, 2025.

What was Enveric's loss per share in Q1 2025?

The basic and diluted loss per share for Q1 2025 was $1.22.

Last updated: May 14, 2025