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EPS-3903 is a Potent and Selective Oral STAT6 Inhibitor That Blocks Th2 Inflammation in a House Dust Mite-Induced Asthma Mouse Model

Key Takeaway: EPS-3903 is a newly identified oral inhibitor of STAT6, showing significant potential in blocking Th2 inflammation. This compound was tested in a house dust mite-induced asthma mouse model, demonstrating its effectiveness in managing asthma-related inflammation. The findings suggest a promising avenue for treating asthma and related conditions.
Price reaction · baseline $13.45 (2026-05-18 close) · hit pre-market · 1 other ENTA headline(s) in the window, move may be shared
day 0 close · peak
+2.3%

Market Sentiment Analysis

POSITIVE FACTORS

  • EPS-3903 shows potent and selective inhibition of STAT6.
  • The compound effectively blocks Th2 inflammation.
  • Demonstrated efficacy in a relevant asthma mouse model.

BiopharmaWatch Analysis

From our catalyst data and publicly available data · not financial advice
Cash runway
~63 mo
Minimal dilution risk
Lead asset
EDP-235
Phase 2 · COVID-19

Full Press Release Details

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• Contact Us
• About Us
• Management Team
• Board of Directors
• Timeline
• Overview
• Hepatitis C Virus
• Respiratory Syncytial Virus
• SARS-CoV-2
• Immunology KIT Inhibition STAT6 Inhibition MRGPRX2
• KIT Inhibition
• STAT6 Inhibition
• MRGPRX2
• Overview
• Publications
• Overview
• Clinical Trials
• Expanded Access Policy
• Resources
• Join Us
• Culture
• Core Values
• Testimonials
• Benefits
• Partnering
• Overview
• Press Releases
• Events & Presentations
• Stock Information Stock Quote & Chart Historic Price Lookup Investment Calculator Analyst Coverage
• Financials Quartlery Results Annual Reports SEC Filings
• Corporate Responsibility Overview Environmental Social Governance
• Investor Resources Investor FAQs RSS Feed
• 2026 Annual Meeting
• Email Alerts
• Stock Quote & Chart
• Historic Price Lookup
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• Analyst Coverage
• Quartlery Results
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Frequently Asked Questions

What is EPS-3903?

EPS-3903 is a potent and selective oral inhibitor of STAT6.

How does EPS-3903 work?

It blocks Th2 inflammation, which is significant in asthma management.

In what model was EPS-3903 tested?

It was tested in a house dust mite-induced asthma mouse model.

What condition does EPS-3903 target?

EPS-3903 targets asthma and related inflammatory conditions.

Last updated: May 19, 2026