Full Press Release Details
Eloxx Pharmaceuticals
Provides Update on the Impact of Novel Coronavirus (COVID-19) on
Phase 2 Clinical Trials in Cystic Fibrosis
Enrollment in our Phase 2 Cystic Fibrosis
Trials has been paused temporarily in response to the COVID-19 pandemic
Cystic Fibrosis patients, especially
those with nonsense mutations, are at increased risk of severe illness
Waltham, MA. - March
25, 2020 - Eloxx Pharmaceuticals, Inc., (NASDAQ: ELOX) a clinical-stage
biopharmaceutical company dedicated to the discovery and development of novel therapeutics to treat cystic fibrosis and other diseases
caused by nonsense mutations limiting production of functional proteins, today announced that enrollment in our Phase 2 clinical
trials for ELX-02 in cystic fibrosis have been temporarily paused in response to the COVID-19 pandemic. Our goals are to avoid
unnecessary exposure in at-risk populations, to maintain the integrity of our study data and to support global healthcare providers
in their commitment to ensure patient safety.
Public health authorities worldwide have recommended that people
at high risk stay at home as much as possible, cancel non-essential doctor's visits and avoid unnecessary exposure to people
and public spaces. Cystic Fibrosis patients, especially those with nonsense mutations, have compromised lung function and may be
at increased risk of severe illness in the event of a COVID-19 infection.
"Enrollment in our Phase 2 clinical trials
in cystic fibrosis has been temporarily paused as the health and safety of our employees, healthcare workers, and patients must
be our highest priority during this crisis. In accordance with the guidance provided by the U.S. Centers for Disease Control, World
Health Organization and national, state and local governments in the United States and abroad, we are taking appropriate steps
to help flatten the COVID-19 infection curve and reduce the risk in the most vulnerable patients," said Dr. Gregory Williams,
Chief Executive Officer of Eloxx. "COVID-19 is rapidly evolving and we continue to work closely with our clinical sites and
investigators. We remain committed to completing enrollment in this Phase 2 proof of concept clinical trial program and reporting
top line data as soon as feasible. We will provide further updates when appropriate."
About Eloxx Pharmaceuticals
Eloxx Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical
company developing novel RNA-modulating drug candidates (designed to be eukaryotic ribosomal selective glycosides) that are formulated
to treat rare and ultra-rare premature stop codon diseases. Premature stop codons are point mutations that disrupt protein synthesis
from messenger RNA. As a consequence, patients with premature stop codon diseases have reduced or eliminated protein production
from the mutation bearing allele accounting for some of the most severe phenotypes in these genetic diseases. These premature stop
codons have been identified in over 1,800 rare and ultra-rare diseases. Read-through therapeutic development is focused on
extending mRNA half-life and increasing protein synthesis by enabling the cytoplasmic ribosome to read through premature stop codons
to produce full-length proteins. Eloxx's lead investigational product candidate, ELX-02, is a small molecule drug candidate
designed to restore production of full-length functional proteins. ELX-02 is in the early stages of clinical development focusing
on cystic fibrosis and cystinosis. ELX-02 is an investigational drug that has not been approved by any global regulatory body.
Eloxx's preclinical candidate pool consists of a library of novel drug candidates designed to be eukaryotic ribosomal selective
glycosides identified based on read-through potential. Eloxx recently announced a new program focused on rare ocular genetic disorders.
Eloxx is headquartered in Waltham, MA, with operations in Rehovot, Israel. For more information, please visit www.eloxxpharma.com.
Forward-Looking Statements
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Actual results or outcomes may differ materially from those implied by the forward-looking statements as a result of the impact
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at a cost acceptable to the Company, if at all; the successful implementation of the Company's research and development programs
and collaborations; the Company's ability to obtain applicable regulatory approvals for its current and future product candidates;
the acceptance by the market of the Company's products should they receive regulatory approval; the timing and success of
the Company's preliminary studies, preclinical research, clinical trials, and related regulatory filings; the ability of
the Company to consummate additional financings as needed; as well as those discussed in more detail in our Annual Report on Form
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