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NorthStrive Biosciences Files New U.S. Patent Application for EL-22 Targeting Muscle Preservation in Humans

Key Takeaway: NorthStrive Biosciences has filed a new U.S. patent application for EL-22, a myostatin-engineered probiotic technology aimed at muscle preservation in humans. This application seeks to protect a pharmaceutical product intended for patients with muscle loss linked to conditions like sarcopenia and neurological disorders. The development is part of NorthStrive's broader strategy to build its intellectual property portfolio and offers potential therapeutic solutions that address increasing concerns about muscle health.
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POSITIVE FACTORS

  • NorthStrive's new patent application for EL-22 demonstrates innovation in muscle preservation technology.
  • The therapeutic application of EL-22 targets significant health issues such as muscle loss due to various conditions.
  • Filing strengthens NorthStrive's intellectual property portfolio, enhancing its market position.

Full Press Release Details

NorthStrive Biosciences Files New U.S. Patent
Application for EL-22 Targeting Muscle Preservation in Humans
NEWPORT BEACH, Calif, April 28, 2026 (GLOBE NEWSWIRE)
-- NorthStrive Biosciences Inc. ("NorthStrive" or the "Company"), a wholly owned subsidiary of PMGC Holdings Inc.
(Nasdaq: ELAB) ("PMGC"), today announced the filing of a new U.S. patent application expanding its proprietary EL-22, a myostatin-engineered
probiotic technology, into human pharmaceutical applications.
The patent application (U.S. Application No. 19/655,160)
covers the development of a formulated pharmaceutical product utilizing EL-22 for use in human patients suffering from muscle loss. The
application includes protection for specific dosing regimens and formulations targeting a broad range of muscle-wasting conditions.
The proposed therapeutic use of EL-22 is intended
to address muscle loss associated with conditions such as sarcopenia, muscle disuse atrophy, and certain neurological disorders. This
filing expands NorthStrive's intellectual property strategy, building on prior applications focused on muscle preservation and growth.
NorthStrive's lead asset, EL-22, leverages
a myostatin engineered probiotic approach designed to support muscle preservation and growth, including in patients undergoing weight
loss treatments such as GLP-1 receptor agonists.
This newly filed patent application is intended
to strengthen NorthStrive's expanding intellectual property portfolio and reflects the Company's focus on muscle health therapeutics
across pharmaceutical and adjacent markets.
About NorthStrive Biosciences Inc.
Biosciences Inc., a PMGC Holdings Inc. company, is a biopharmaceutical company focused on the development and acquisition of cutting-edge
therapeutic technologies. The Company is advancing a pipeline of assets targeting muscle preservation, metabolic health, and related
About PMGC Holdings Inc.
Inc. is a diversified holding company that manages and grows its portfolio through strategic acquisitions, investments, and development
across multiple industries. PMGC is focused on building long-term shareholder value through operational excellence and disciplined capital
allocation. For more information, please visit https://www.pmgcholdings.com.
Forward-Looking Statements
Statements contained in this press release regarding
matters that are not historical facts are "forward-looking statements" within the meaning of the Private Securities Litigation
Reform Act of 1995, as amended. Words such as "believes," "expects," "plans," "potential,"
"would" and "future" or similar expressions such as "look forward" are intended to identify forward-looking
statements. Forward-looking statements are made as of the date of this press release and are neither historical facts nor assurances of
future performance. Instead, they are based only on our current beliefs, expectations and assumptions regarding the future of our business,
future plans and strategies, projections, anticipated events and trends, the economy, activities of regulators and future regulations
and other future conditions. Because forward-looking statements relate to the future, they are subject to inherent uncertainties, risks
and changes in circumstances that are difficult to predict and many of which are outside of our control. Although PMGC believes that the
expectations expressed in these forward-looking statements are reasonable, it cannot assure you that such expectations will turn out to
be correct, and PMGC cautions investors that actual results may differ materially from the anticipated results. Therefore, you should
not rely on any of these forward-looking statements. These and other risks are described more fully in PMGC's filings with the United
States Securities and Exchange Commission ("SEC"), including the "Risk Factors" section of PMGC's Annual
Report on Form 10-K for the year ended December 31, 2025, filed with the SEC on March 30, 2026, and its other documents subsequently filed
with or furnished to the SEC. Investors and security holders are urged to read these documents free of charge on the SEC's web site
at www.sec.gov. All forward-looking statements contained in this press release speak only as of the date on which they were made. Except
to the extent required by law, PMGC undertakes no obligation to update such statements to reflect events that occur or circumstances that
exist after the date on which they were made.

Frequently Asked Questions

What is the focus of NorthStrive Biosciences' new patent application?

The application focuses on EL-22, a myostatin-engineered probiotic for muscle preservation.

Which conditions does EL-22 aim to address?

EL-22 targets muscle loss from conditions like sarcopenia and muscle disuse atrophy.

How does EL-22 support muscle health?

EL-22 employs a myostatin engineered probiotic approach to enhance muscle preservation.

What does this patent filing expand?

It expands NorthStrive's intellectual property strategy focused on muscle health therapeutics.

What company owns NorthStrive Biosciences?

NorthStrive is a wholly owned subsidiary of PMGC Holdings Inc.

Last updated: Apr 28, 2026