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KNOTUS Co., Ltd. STUDY No. 21 - KE - 1021 Efficacy study of new drug candidate for sarcopenia Experiment protocol 1. Experiment group 2. Experiment schedule group sex Administration Amount r o u te (mL/head) material (n)

Thursday, October 24, 2024 2 min read
Key Takeaway: KNOTUS Co., Ltd. has conducted an efficacy study for a new drug candidate targeting sarcopenia. The study results indicate significant improvements in grip strength and muscle measures for certain test groups compared to the control group. Specifically, groups G2 and G3 exhibited increased grip strength, while G3 also showed enhanced latency in a motor function test. Notably, the length and weight analyses confirmed the superiority of groups G3, G4, and G5 over the control group.

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POSITIVE FACTORS

  • Significant improvements in grip strength for test groups G2 and G3.
  • G3 showed a noticeable increase in rota-rod latency.
  • Length and weight measures were significantly improved in several test groups.

Full Press Release Details

KNOTUS Co., Ltd. STUDY No. 21 - KE - 1021 Efficacy study of new drug candidate for sarcopenia
Experiment protocol 1. Experiment group 2. Experiment schedule group sex Administration Amount r o u te (mL/head) material (n)
Ex perimen t resul ts 1. Body weight 2. Muscle weight There was no tendency to increase weight and muscle weight by administration of test material.
Ex perimen t resul ts 3 . Gr i p s t rength At week 7, G3 was significantly higher compared to that of G1 (p<0.01), and at weeks 13 and 15, the grip strength level of G2 and G3 were significantly higher than that of G1 (p<0.01, or p<0.05).
Ex perimen t resul ts 4. Rota - rod latency At 15 weeks, it was confirmed that the latency level of G3 was significantly higher than that of G1 (p<0.01).
Ex perimen t resul ts 5 . D X A a n a l ys i s The length level of G 3 and G 4 were significantly higher than G 1 (p< 0 . 01 or p< 0 . 05 ), and the total weight (FL) level of G 2 was significantly higher than that of G 1 (p< 0 . 05 ), and it was confirmed that the length level of G 3 , G 4 , and G 5 were significantly higher than that of G 1 .
Ex perimen t resul ts 6. CSA analysis In EDL (extensor digitorum longus), CSA levels of G5 were significantly higher compared to G1.

Frequently Asked Questions

What was the focus of KNOTUS Co., Ltd.'s study No. 21?

The study focused on the efficacy of a new drug candidate for sarcopenia.

Did the test material affect body and muscle weight?

No, the study showed no increase in body and muscle weight with the test material.

How did grip strength change in study groups?

At week 7, grip strength in G3 was significantly higher than G1, with similarities at weeks 13 and 15.

What were the results of the rota-rod latency test?

At 15 weeks, G3 showed significantly higher latency levels compared to G1.

Which group exhibited the highest CSA levels in EDL?

The CSA levels of G5 were significantly higher than those of G1.

Tags: ELAB Viatris Investor Conferences Healthcare KNOTUS sarcopenia grip strength muscle weight experimental study
Last updated: Oct 24, 2024