DELCATH SYSTEMS, INC Forward looking Statements This presentation contains forward looking statements, within the meaning of the federal securities laws, related to future events and future financial performance which in

Rare late AEs (1 patient each) included hair loss, skin rash, myelosuppression and persistent transaminases (elevated liver enzymes) o AEs seen were grade 1 (n=12), 2 (n=13), 3 (n=5) and 4 (n=1) o Grade 4 complication was pulmonary edema due to fluid overload 25 DELCATH SYSTEMS, INC Recent Data Presentations SSO 2015 Moffitt Cancer Center (Tampa, FL) Hepatic Progression Free and Overall Survival after Regional Therapy to the Liver for Metastatic Melanoma o Retrospective analysis of 30 patients with ocular or cutaneous melanoma treated with Melphalan/HDS (n=10), chemoembolization (CE, n=12), and yttrium 90 (Y90, n=6) o Study showed significant difference in hepatic progression free survival (HPFS) for Melphalan/HDS (310 days), CE (80 days), Y90 (54 days) o Median overall survival (OS) longest for Melphalan/HDS (736 days) vs Y90 (285 days) CE (265 days), but did not reach statistical significance o Authors concluded that HPFS and progression free survival (PFS) were significantly prolonged with Melphalan/HDS vs CE and Y90 26 DELCATH SYSTEMS, INC Coming Soon Leiden University Medical Center in the Netherlands Treating Unresectable Liver Metastases Of Uveal Melanoma With Percutaneous Hepatic Perfusion With Melphalan Southampton University in the United Kingdom Liver Directed Treatment Of Metastatic Uveal Melanoma By Chemosaturation Via Percutaneous Hepatic Perfusion A Single Centre Experience Frankfurt University Hospital Chemosaturation with Percutaneous Hepatic Perfusion of Melphalan for Hepatic Metastases from Uveal Melanoma: Multiinstitutional Evaluation 27 DELCATH SYSTEMS, INC Cash Capital Resources Cash Cash Equivalents $19.1 million at July 31, 2015 Debt None ATM Program 1 $40 million available at July 31, 2015 Shares Outstanding 21.8 million (40.7 million fully diluted 2 ) at July 31, 2015 1) Subject to market conditions and certain limitations 2) Fully diluted includes approximately 0.8 million options and 18.1 million warrants Focused Spending and Resources to Support Execution of Near term Plan In Summary Attractive multi billion dollar orphan drug business model Unique, highly differentiated solution Late stage asset in U.S. with active clinical development program Early commercial activity in EU with increasing sales/procedure volumes Compelling emerging data Imminent valuation milestones Experienced pharmaceutical management team executing a data driven plan 28 DELCATH SYSTEMS, INC 30 DELCATH SYSTEMS, INC 2015 DELCATH SYSTEMS, INC.

FDA granted Melphalan/HDS orphan drug designation for treatment of OM Sources: ACS, SEER, NIH, OMF, KOL Interviews, 2014 3 rd Party Analysis Proven Efficacy in Attractive Orphan Opportunity 17 DELCATH SYSTEMS, INC Intent to Treat Analysis (June 2012) 5.3 mos improvement in hPFS Hazard ratio = 0.50 (95% CI 0.31 0.80) p=0.0029 Months 7.0 1.7 1 . 0 0 . 8 0 . 6 0 . 4 0 . 2 0 . 0 Proportion of patients surviving 5.3 mo Chemosaturation (CS PHP) Previous Ocular Melanoma Mets Phase 3 Results 0 5 10 15 20 25 30 Best alternative care (BAC) Hepatic Progression Free Survival (hPFS) Chemosaturation (CS PHP) 3.8 mos improvement in PFS Hazard ratio = 0.42 (95% CI 0.27 0.64) p 0.0001 Overall Progression Free Survival (Investigator) Proportion of patients surviving Months 5.4 1.6 1 . 0 0 . 8 0 . 6 0 . 4 0 . 2 0 . 0 3.8 mo Intent to Treat Analysis (June 2012) Best alternative care (BAC) 0 5 10 15 20 25 30 35 40 45 50 55 Clinically Meaningful Benefit Previously Demonstrated for Metastatic OM Patients 4 subjects remain alive at 5 8 years All were recipients of CS PHP 18 DELCATH SYSTEMS, INC HCC ICC Rationale Significant opportunity in the U.S. and EU o HCC most common primary cancer of the liver o ~76,000 cases diagnosed annually o ICC represents ~15% of new HCC cases diagnosed annually o ~90% HCC/ICC PTS not candidates for surgical resection o 20 30% PTS candidates for focal interventions Large unmet medical need in first line therapy o Only one approved systemic therapy for HCC in the U.S., EU and certain Asian markets FDA granted Melphalan/HDS orphan drug designations for treatment of unresectable HCC ICC Efficacy signals from early commercial uses in EU *Sources: WHO, KOL Interviews, 2014 3 rd Party Analysis Large, Deadly Disease in Need of Better Treatments 19 DELCATH SYSTEMS, INC Prior FDA Experience New Drug Application (NDA) submitted August 2012 seeking indication in OM liver metastases with first generation filter and procedure ODAC meeting in May 2013 o Efficacy shown with statistical significance o Negative vote due to benefit/risk analysis o Complete FDA Delcath ODAC briefing materials available at www.delcath.com/clinical research/clinical bibliography/ Complete Response Letter (CRL) issued September 2013 FDA requests include, but not limited to: o Well controlled randomized trial(s) to establish the safety and efficacy using the to be marketed device configuration o Overall survival as the primary efficacy outcome measure o Demonstrate clinical benefits outweigh risks FDA Learnings Provide Beneficial Clinical Study Roadmap 20 DELCATH SYSTEMS, INC Risks Observed in Previous Clinical Program Risks observed with prior product and procedure protocol Integrated safety population of patients showed risks associated with melphalan/HDS included: o 4.1% incidence of death due to adverse reactions o 4% incidence of stroke o 2% reported incidence of myocardial infarction in the setting of an incomplete cardiac risk assessment o 70% incidence of grade 4 bone marrow suppression with a median time of recovery of greater than 1 week o 18% incidence of febrile neutropenia, along with the additive risk of hepatic injury, severe hemorrhage and gastrointestinal perforation Deaths due to certain adverse reactions did not occur again during the clinical trials following the adoption of related protocol amendments Safety improvements implemented Treating Physicians in U.S. and EU Report Improved Safety Profile 21 DELCATH SYSTEMS, INC Growing Body of Clinical Support for CHEMOSAT EU KOL Forum affirms benefits to liver cancer patients o 4 TX being administered; shown to be safe and well tolerated o Providing clinical benefit and good QoL o Reimbursement continues to be covered through individual funding requests Abstracts Accepted at Major Medical Meetings o ESSO 2014 o SSO 2015 o ASCO 2015 o CIRSE 2015 o EADO 2015 o ESMO 2015 o RSNA 2015 22 DELCATH SYSTEMS, INC Recent Data Presentations ECCO 2015 Leiden University Medical Center, Erasmus Medical Center (the Netherlands) Treating Unresectable Liver Metastases of Uveal Melanoma with (Percutaneous) Isolated Hepatic Perfusion with Melphalan: Results from Two Experienced Centers Investigators compared TX with IHP and PHP for ocular melanoma liver metastases IHP cohort (n=30) treated between 1999 and 2009 o PFS was 6 mos o Disease recurrence mainly in the liver o OS was 10 mos (vs 6 mos historic avg for IHP) PHP cohort ( n=9); PTS received 15 PHP TX since Feb 2014 o Max follow up period was 14 mos o 8 PTS still alive, 7 without disease progression o Decrease in red/white blood cell count observed following TX; 3 PTS received blood transfusion o TX overall was well tolerated Conclusion: PHP appears to be effective/safe procedure in select patients with unresectable liver metastases from CRC or OM and can be repeated 23 DELCATH SYSTEMS, INC Recent Data Presentations CIRSE 2015 Leiden University Medical Center (the Netherlands) Safety and efficacy of Delcath 2 nd Generation filter in PHP with melphalan for unresectable hepatic metastases of colorectal cancer and uveal melanoma 15 PHP procedures performed with CHEMOSAT on 10 pts; PK blood samples baseline, set intervals PHP performed with melphalan dose of 3mg/kg; 1st blood sample filtration efficiency = 93% Grade 3 complications (mostly leukocytopenia, thrombocytopenia) in 7 pts; febrile neutropenia (w/bacterial pharyngitis) in 1 pts (not seen following introduction of growth factors) Conclusion: 2 nd and acceptable morbidity Southampton University (United Kingdom) Lessons and Early Results from the Largest Single Center Experience in Europe of Treating Ocular Melanoma Liver Metastases with Chemosaturation via Percutaneous Hepatic Perfusion Retrospective analysis of 22 pts; 20 received TX w/PHP 11 pts alive after median 280 days; one complete response 1yr post TX 9 deaths from disease progress after median 264 days post TX Complete response in liver in 2 pts (10%), 13 pts (65%) had partial liver response, 2 pts (10%) had stable disease 3mos Conclusion: PHP effective palliative TX in bleak disease with an acceptable side effect profile Generation filter efficiency very high; PHP associated with no mortality 24 DELCATH SYSTEMS, INC Recent Data Presentations ASCO 2015 Southampton University Hospital (UK) o Analysis of 20 ocular melanoma patients who received 34 TX o Eleven patients remain alive after a median of 280 days with one complete response ongoing at 1 year o From the diagnosis of liver metastases, 11 patients (55%) survived to one year and 3 (15%) for 2 years; no procedure related deaths were seen o ORR 85%: 2 patients (10%) demonstrated stable disease for 3 months, 13 patients (65%) had a partial response, 2 patients (10%) demonstrated complete response o Nine deaths from disease progression occurred after a median of 264 days from the first procedure Adverse Events o Early AEs often expected with percutaneous hepatic perfusion (PHP) were observed including coagulopathy, electrolyte disturbances and transient transaminases (elevated liver enzymes).

Phase 2 Program HCC (unresectable confined to the liver) Protocol 201 (U.S. only) Evaluate ORR (mRECIST) Assess safety, PFS Characterize systemic exposure of melphalan Assess patient QoL Protocol 202 (EU only) Evaluate ORR (mRECIST) Assess safety, PFS Characterize systemic exposure of melphalan Assess patient QoL ICC (unresectable confined to the liver) Added to 202 HCC trial protocol ORR of Melphalan/HDS treatment in patients with intra hepatic cholangiocarcinoma (ICC) Other measures as specified in the 202 EU protocol Signal seeking go/no go decision 2H 2015 Investigator Initiated Trials mCRC University of Leiden study; 10 patients treated to date HCC Johannes Wolfgang Goethe University Hospital (Frankfurt) study; different patient selection from 202 study; open for enrollment EU Commercial Registry EU Commercial Cases Open for enrollment; data collection on safety, QoL assessments Potential efficacy signals in additional tumor types Support reimbursement in key markets Safety, efficacy of Melphalan/HDS treatment followed by sorafenib Safety, efficacy of Melphalan/HDS treatment w/o sorafenib in patients with unresectable liver cancer 16 DELCATH SYSTEMS, INC OM Metastases Rationale OM has high incidence of liver metastases o Up to 90% of patients with metastases will have liver involvement o Life expectancy of approximately 6 months o 5,700 8,600 cases of OM liver metastases diagnosed in U.S. and EU annually Clear efficacy signal seen in prior Phase 3 trial of Melphalan/HDS Currently no standard of care Believed to be fastest pathway to NDA approval in the U.S.

Market Opportunity Cancers Of The Liver Remain a Multibillion Dollar Unmet Medical Need Cancer Type Annual Incidence 1 Eligible PTS 2 Annual Potential Market Opportunity (Millions) 3,5 Annual Potential Market Opportunity (Millions) 4,5 Ocular Melanoma 5,700 8,600 2,600 4,300 $104 $215 $208 $430 Intrahepatic Cholangiocarcinoma (ICC) 11,500 6,500 $260 $330 $520 $660 Hepatocellular Carcinoma (HCC) 64,500 7,600 14,700 $304 $735 $608 $1,470 Colorectal (CRC) 411,000 40,000 55,000 $1,600 $2,750 $3,200 $5,500 Total EU U.S. 492,700 495,600 56,700 80,500 $2,268 $4,030 $4,536 $8,060 Notes: 1) Globocan, American Cancer Society 2) LEK, Strategy , Company Estimates 3) Assumes average of 2TX/patient 4) Assumes average of 4TX/patient 5) Assumes $20,000 $25,000 USD/TX 11 DELCATH SYSTEMS, INC European Commercial Activity CHEMOSAT Hepatic Delivery System Approved as Class IIb Medical Device; kit supplied without melphalan Broad indication for intra hepatic administration of melphalan hydrochloride and subsequent filtration of the venous blood return 250 commercial procedures performed in leading cancer centers across the EU ZE National Procedure Code Established for 2016; 2015 Reimbursement via Individual Funding Requests UK private pay insurance; block grants pending 2015 YTD EU Sales exceed 2014 on local currency basis 12 DELCATH SYSTEMS, INC ZE Reimbursement First National Reimbursement Coverage Mechanism for CHEMOSAT in Europe Establishes DRG Code for CHEMOSAT procedures in Germany Augments coverage under established codes until dedicated, comprehensive DRG code can be established Hospitals negotiate reimbursement level with insurers beginning Feb 2016 Replaces annual NUB process ZE Coverage in response to applications submitted by German Radiology Society; represents significant support for CHEMOSAT TX for cancers in the liver 13 DELCATH SYSTEMS, INC Increasing Expanding Clinical Utilization Utilization Expanding Into Other Tumor Types Beyond Ocular Melanoma All other includes: cutaneous melanoma, HCC, ICC, CRC, breast mets, neuroendocrine mets, pancreatic, mucosal melanoma, sarcoma, and gastric mets 14 DELCATH SYSTEMS, INC Clinically Differentiated Results Phase 1, 2 and 3 trials produced positive results in multiple histologies Melanoma Liver Mets o Positive Phase 3 results in hepatic metastatic melanoma o n=93 (90% ocular melanoma, 10% cutaneous melanoma) Neuroendocrine Tumor (NET) Liver Mets o mNET cohort in Phase 2 trial showed encouraging 42% objective response rate (ORR) vs. ~10% for approved targeted therapy o Median overall survival of ~32 months on ITT basis Hepatocellular Carcinoma (HCC) o Positive signal with high dose melphalan in HCC cohort of Phase 2 trial (5/8 patients) is encouraging when approved systemic therapies have modest efficacy and challenges with tolerability Colorectal Cancer (CRC) Liver Mets o Data from surgical Isolated Hepatic Perfusion (IHP) with melphalan indicates strong potential in well defined patient population with earlier stage CRC yielding ~50 60% median response rate and median OS of 17.4 24.8 mos Encouraging Initial Results on a Broad Range of Histologies 15 DELCATH SYSTEMS, INC Clinical Development Program Trials Tumor Objectives Phase 3 Pivotal Trial OM liver mets Global Phase 3 trial to start 2H 2015 ~240 PTS, 30 mos accrual, 2017 Interim Analysis Primary endpoint: Overall Survival (OS) Believed to be fastest pathway to NDA approval in the U.S.

These factors, and others, are discussed from time to time in our filings with the Securities and Exchange Commission including the section entitled Risk Factors in our most recent Annual Report on Form 10 K and our Reports on Form 10 Q and Form 8 K. 3 DELCATH SYSTEMS, INC About Delcath Systems A specialty pharmaceutical and medical device oncology company with a principal therapeutic focus on the treatment of primary liver cancer and other cancers that have metastasized to the liver Proprietary system isolates the liver from circulation, delivers a substantially higher concentration of chemotherapy (melphalan) compared with systemic doses, and filters most of the chemotherapy out of the blood prior to returning it to the patient In late stage clinical development in the U.S. with initial commercial activities underway in Europe Initially pursuing orphan indications in metastatic ocular melanoma, hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) Seeking to Make a Clinically Meaningful Difference For Cancer Patients With Liver Dominant Disease 4 DELCATH SYSTEMS, INC Whole Organ Focus Disease Control Our Solution Our proprietary system isolates the liver circulation, delivers a high concentration of chemotherapy (melphalan) and filters most of the chemotherapy out of the blood prior to returning it to the patient The procedure typically takes approximately 2 3 hours to complete and involves a team including the interventional radiologist, oncologist, anesthesiologist and perfusionist We believe more than 250 treatments with improved device and procedure provide confidence safety can be validated in a controlled setting Liver Isolated Via Double Balloon Catheter In IVC Melphalan Infused Directly Into Liver Via Catheter In Hepatic Artery Blood Exiting The Liver Filtered By Proprietary Extra corporeal Filters 5 DELCATH SYSTEMS, INC Investment Highlights Large, Compelling Market Opportunity Late stage asset clinically meaningful efficacy demonstrated in 600 procedures and in multiple tumor types Active clinical program initiating global Phase 3 study in o c ular melanoma; HCC/ICC Phase 2 program ongoing Unique, highly differentiated solution multiple orphan designations create barriers to entry Early stage commercialization in EU 250 procedures performed in EU with 2nd Generation product and protocol Imminent valuation milestones 2015 value drivers include publications, reimbursement and clinical data Attractive business model initial orphan focus and anticipated high gross margins form basis of profitable long term model Experienced management team aligned with requirements of clinically driven pharmaceutical industry 6 DELCATH SYSTEMS, INC 2015 Milestones 1H 2015 NUB reimbursement decision in Germany Value 4 awarded for 2015 Submit Phase 3 metastatic melanoma trial results for publication EU registry open for enrollment ICC cohort open for enrollment 2H 2015 ZE Reimbursement in Germany EADO Abstracts released RSNA Abstract released Initiation of global Phase 3 metastatic ocular melanoma program Interim evaluation on HCC/ICC program Executing on Multiple Fronts to Create Value 7 DELCATH SYSTEMS, INC The Liver: A Life Limiting Organ Cancers of the liver remain a major unmet medical need o Large global patient population approximately 1.2 million* patients diagnosed annually with primary or metastatic liver cancer o The liver is often the life limiting organ for cancer patients and one of the leading causes of cancer death o Prognosis after liver involvement is poor, with overall survival generally less than 12 months CHEMOSAT Melphalan/HDS is a proprietary product uniquely positioned to potentially treat the entire liver as a standalone or complementary therapy * SOURCE 2008 GLOBOCAN Effective Liver Cancer Treatment Remains a Major Unmet Medical Need 8 DELCATH SYSTEMS, INC Existing Liver Cancer Treatments Landscape Existing Liver Cancer Treatments Have Limitations Treatment Advantages Disadvantages Systemic Non invasive Repeatable Systemic toxicities Limited efficacy in liver Regional (e.g., Isolated Hepatic Perfusion) Therapeutic effect Targeted Invasive/limited repeatability Multiple treatments are required but not possible Focal (e.g., surgery, radioembolization, chemoembolization, radiofrequency ablation) Partial removal or treatment of tumors Only 10% 20% are resectable Invasive and/or limited repeatability Treatment is limited by tumor size, number of lesions and location Tumor revascularization Cannot treat diffuse disease 9 DELCATH SYSTEMS, INC Melphalan Dosing Background Well understood, dose dependent, tumor preferential, alkylating cytotoxic agent that demonstrates little to no hepatic toxicity Dose administered directly to liver is substantially higher than that of systemic IV chemotherapy Melphalan, an established chemotherapy agent, is proven active at high doses with broad antitumor activity An Established Drug for Liver Cancer Therapy Type Dosing (mg/kg) Multiple Myeloma (label) 0.25 Chemoembolization 0.62 Surgical Isolated Hepatic Perfusion (IHP) 1.50 Myeloablation 2.50 3.50 Melphalan/HDS (PHP) 3.00 10 DELCATH SYSTEMS, INC Total Available EU U.S.

FDA, acceptance of the Phase 3 trial publication, the impact of presentations and abstracts at major medical meetings and congresses (SSO, ASCO, CIRSE, ESMO, EADO, RSNA) and future clinical results consistent with the data presented, approval of the current or future Melphalan/HDS system for delivery and filtration of melphalan or other chemotherapeutic agents for various indications in the U.S. and/or in foreign markets, actions by the FDA or other foreign regulatory agencies, our ability to successfully enter into strategic partnership and distribution arrangements in foreign markets and the timing and revenue, if any, of the same, uncertainties relating to the timing and results of research and development projects, and uncertainties regarding our ability to obtain financial and other resources for any clinical trials, research, development, and commercialization activities.

Forward looking statements are subject to known and unknown risks and uncertainties and are based on potentially inaccurate assumptions, which could cause actual results to differ materially from expected results, performance or achievements expressed or implied by statements made herein. Our actual results could differ materially from those anticipated in forward looking statements for many reasons, including, but not limited to, uncertainties relating to: the timing and results of future clinical trials including without limitation the OM, HCC, ICC, and mCRC trials in the Company s Clinical Development Program, clinical adoption, use and resulting sales, if any, for the CHEMOSAT system in Europe, our ability to obtain reimbursement for the CHEMOSAT system and the impact on sales, if any, of reimbursement in various markets, including without limitation Germany and the United Kingdom, our ability to successfully commercialize the Melphalan/HDS system and the potential of the Melphalan/HDS system as a treatment for patients with primary and metastatic disease in the liver, the Company's ability to satisfy the requirements of the FDA's Complete Response Letter relating to the ocular melanoma indication and the timing of the same, approval of the Melphalan/HDS system by the U.S.

Investor Presentation (NASDAQ: DCTH) October 2015 Exhibit 99.1 2 DELCATH SYSTEMS, INC Forward looking Statements This presentation contains forward looking statements, within the meaning of the federal securities laws, related to future events and future financial performance which include statements about our expectations, beliefs, plans, objectives, intentions, goals, strategies, assumptions and other statements that are not historical facts.