DELCATH SYSTEMS, INC Forward looking Statements Private Securities Litigation Reform Act of 1995 provides a safe harbor for forward looking statements made by the Company or on its behalf. This presentation contains forw

Korea 54 DELCATH SYSTEMS, INC CHEMOSAT CENTERS Appendix 8 Active CHEMOSAT Centers in Europe Milan, Italy European Institute of Oncology (IEO) Frankfurt, Germany Johann Wolfgang Goethe Universit t (JWG) Villejuif, France Cancer Institute Gustave Roussy (IGR) Amsterdam, The Netherlands Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital Bordeaux, France H pital Saint Andr (St Andre) Galway, Ireland University Hospital Galway (UHG) Southampton, United Kingdom Southampton University Hospital (SUH) G ttingen, Germany University Medical Center G ttingen (UMG) Varese, Italy Varese University Hospital (VUH) 55 DELCATH SYSTEMS, INC

Korea where doxorubicin has a broad label for multiple tumor types Multiple published Phase I/II studies from MD Anderson Cancer Center and Yale with percutaneous hepatic perfusion (PHP) and Kobe University using doxorubicin show promising response rates for HCC* Plan to use CHEMOSAT Delivery System for Doxorubicin in Asia Phase III 2L HCC trials Addressing the Large HCC Market Opportunity in China 51 DELCATH SYSTEMS, INC NON US/EU REGULATORY UPDATE Appendix 7 52 DELCATH SYSTEMS, INC 53 DELCATH SYSTEMS, INC International Strategy beyond EU and US Combination of Strategic Partnerships and Specialty Distributors Leverage CE Mark to obtain reciprocal regulatory approvals for CHEMOSAT Systems in other international markets o Obtained approval for Gen 2 CHEMOSAT Delivery System for Melphalan in Australia International regulatory submissions status: Application submitted and expected approvals in Hong Kong 2013 Singapore 2013 Argentina 2013 Brazil 2014 Intend to submit applications China Taiwan Mexico Japan Israel Utilize 3 rd party melphalan and doxorubicin available to physicians S.

Chir Gastroenterol 2003;19:370 376. 2) Curley SA et al. Ann Surg Oncol 1994;1:389 99. 3) Ravikumar TS et al. J Clin Oncol 1994;12:2723 36. 4) Hwu WJ et al. Oncol Res 1999;11:529 37. No. of pts No. of PHP/ pt Disease stage (tumor diameter) Treatment Median survival (mo) Response Rates Reference HCC (n=79) CHM (n=23) 1 4 1 2 IV A: n=66 IV B: n=13 All multiple bilobar Extrahepatic disease in 52% Doxorubicin 60 150 mg/m 2 Cisplatin 50 150 mg/m 2 Mitomycin C 50 200 mg/m 2 16 13 HCC pts RR 64.5% 5 year survival 20.3% Kobe 1 Phase I/II HCC (n=11) 1 3 Mean 9.5 cm Doxorubicin 60 120 mg/m 2 6.5 13 (responders) 2 (non responders) RR 20% MDACC 2 Phase I HCC (n=5) CHM (n=8) Other (n=8) 2 4 Extrahepatic disease in 17% Doxorubicin 50 120 mg/m 2 5 FU 1000 5000 mg/m 2 NR RR 22% Yale 3 Phase I HCC (n=7) Other (n=11) 1 10 NR Doxorubicin 90 120 mg/m 2 23 (responders) 8 (non responders) RR 58% Yale 4 Phase I 48 DELCATH SYSTEMS, INC PRODUCT DEVELOPMENT PIPELINE Appendix 6 49 DELCATH SYSTEMS, INC Product Development Pipeline Orphan Drug Ocular Melanoma liver mets Proprietary drug melphalan Melblez Kit All liver cancers melphalan Classified as Medical Device 3 rd party melphalan Gen 2 melphalan CE Mark Doxorubicin system CE Mark CHEMOSAT for additional drugs CHEMOSAT for other organs (lung and brain) HCC, mCRC, mNET indications Initial Opportunity Near Term ( 5 years) Intermediate Term ( 5 years) mCRC and HCC clinical trials Proprietary drug/delivery system for additional drugs Proprietary drug/delivery system for other organs (lung and brain) CHEMOSAT Melphalan in , Taiwan and Japan CHEMOSAT Doxorubicin in China and South Korea 3 rd party doxorubicin CHEMOSAT for additional drugs CHEMOSAT for other organs (lung and brain) CHEMOSAT Melphalan in Australia, New Zealand, and Hong Kong 3 rd party melphalan Development Aligned to Address Significant Market Opportunity 50 DELCATH SYSTEMS, INC E U A S I A U S CHEMOSAT Delivery System for Doxorubicin CE Mark Satisfied all of the requirements to affix the CE Mark to Hepatic CHEMOSAT Delivery System device for intra hepatic arterial delivery and extracorporeal filtration of doxorubicin in October, 2012 Provides basis for partnership opportunities in China and S.

Ann Surg Oncol 2009;16:1852 9 1. Grover AC, et al. Surgery 2004;136:1176 82 2. Noter SL, et al. Melanoma Res 2004;14:67 72 3. Alexander HR Jr, et al. Clin Cancer Res 2000;6:3062 70 7. Van Iersel LB, et al. Ann Oncol 2010;21:1662 7 8. Verhoef C, et al. Ann Surg Oncol 15:1367 74 42 DELCATH SYSTEMS, INC Melphalan Dosing Background Well understood, dose dependent, tumor preferential, alkylating cytotoxic agent that demonstrates little to no hepatic toxicity Manageable systemic toxicities associated with Neutropenia and Thrombocytopenia Drug dosing 12x higher than FDA approved dose via systemic IV chemotherapy Dose delivered to tumor is over 100x higher than that of systemic IV chemotherapy Type Dosing (mg/kg) Multiple Myeloma (label) 0.25 Chemoembolization 0.62 Surgical Isolated Hepatic Perfusion (IHP) 1.50 Myeloablation 2.50 3.50 An Established Drug for Liver Cancer Therapy Percutaneous Hepatic Perfusion ( PHP) 3.00 43 DELCATH SYSTEMS, INC Melphalan Sensitivity: In Vitro Tumor Cell Lines Study We Believe Our Technology Will Be Effective On a Wide Range of Solid Tumors 192 uM 44 DELCATH SYSTEMS, INC PHASE 3 TRIAL Appendix 4 Phase III Clinical Trial Design Cross over Primary Trial Endpoint Statistically significant difference in Hepatic Progression Free Survival ( hPFS ): p 0.05 (IRC) Over 80% of Oncologic drugs approved by FDA between 2005 2007 on endpoints other than overall survival Modeled hPFS for Trial Success: 7.73 months (CS) vs. 4 months (BAC) Secondary Trial Endpoints Investigator hPFS Hepatic objective response rate Overall objective response rate Overall Survival Diluted by Cross Over SAP calls for analysis of various patient subsets Pre PHP (Baseline) Post PHP (22+ Months) Hepatic Response Metastatic Melanoma Fully Powered, 93 Patient, Randomized, Multi Center NCI Led Study PHP = Meblez Kit/CHEMOSAT 45 DELCATH SYSTEMS, INC Best Alternative Care (BAC) Investigator and patient decision (any and all treatments) PHP/Melphalan Treat every 4 weeks x 4 rounds (responders can receive up to 6 rounds) Randomized to PHP 93 patients: ocular or cutaneous melanoma Positive Phase 3 Results Primary endpoint (hPFS by IRC) exceeded, p value = 0.0029, hazard ratio of 0. 50 as of June, 2012 Secondary endpoints consistent with primary endpoints o CS/PHP achieved a median overall PFS of 5.4 months vs. 1.6 months for BAC o OS No difference demonstrated due to heavy crossover from BAC to PHP o Median OS 10.6 months vs. 10.0 months for PHP and BAC respectively OS exploratory analyses supportive of key observations o Median overall survival of 11.4 months for all patients treated with melphalan, including crossover o BAC patients did not cross over to PHP had a median survival of 4.1 months o 6 PHP treated and 2 BAC only patients still alive as of 2/2013 Gen 1 Safety profile consistent with currently approved labeling for melphalan o 30 day deaths on PHP: 3/44 patients (6.8%) 1 Neutropenic Sepsis (2.3%); 1 Hepatic Failure 2.5% (95% tumor burden); 1 gastric perforation o 30 day deaths on BAC: 3/49 patients (6.1%) Trial Outcomes Favorable and Consistent with Special Protocol Assessment 46 DELCATH SYSTEMS, INC o PHP median hepatic progression free survival (hPFS) was 4 fold of control, or 5.3 months improvement o PHP achieved a median hPFS of 7.0 months vs 1.7 months for BAC control o 75% overall clinical benefit (CR + PR + SD) PUBLISHED PHASE 1 / 2 STUDIES OF DOXORUBICIN WITH PHP Appendix 5 47 DELCATH SYSTEMS, INC Phase 1 2 Studies of PHP Doxorubicin For HCC Delivered Safely in Multiple Studies with Promising Response Rates 1) Ku Y et al.

HIGH DOSE MELPHALAN HISTORY AND RATIONALE Appendix 3 40 DELCATH SYSTEMS, INC The Evidence for Melphalan Melphalan, an established chemotherapy agent, is proven active at high doses with broad antitumor activity 41 DELCATH SYSTEMS, INC 6. Van Iersel LB, et al. Ann Oncol 2008;19:1127 34 4. Alexander HR Jr, et al. Clin Cancer Res 2003;9:6343 9 5. Alexander HR Jr, et al.

Korea (Device) Japan (Device) Taiwan (Device) Australia (Device) Total Potential (patients) Potential Market ($MM) 1,2 Total Potential Market #Patients HCC (Primary) 85,780 3,258 8,296 2,152 263 99,749 $ 1,156 Other CRC 31,127 3,245 14,298 1,441 2,031 52,143 $ 642 NET 29,197 1,048 2,759 500 462 33,966 $ 393 Ocular Melanoma 1,765 66 175 31 96 2,134 $ 25 Cutaneous Melanoma 382 43 136 246 1,144 1,951 $ 23 OTHER TOTAL 62,472 4,403 17,368 2,218 3,733 90,194 $ 1,083 TOTAL 148,104 7,661 25,665 4,370 3,996 189,943 $ 2,239 APAC Target Markets Represent Over $2 Billion Potential Market Opportunity Sources: LEK Consulting, GLOBOCAN, Company estimates. 1) Assume 2.5 treatments per patient. 2) Estimated ASP of ~$5K.

Primary cancer incidence 2. Adjusted for predominant disease in the liver (primary or metastatic cancer) 3. Adjusted for addressable patients via Melblez Kit/CHEMOSAT 0 2500 5000 7500 10000 Melanoma 0 5000 10000 15000 20000 25000 30000 NET 0 10000 20000 30000 40000 CRC 0 20000 40000 60000 80000 100000 HCC 36 37 DELCATH SYSTEMS, INC Europe Market by Disease Device Only Germany (Direct) UK (Direct) France (Indirect) Italy (Indirect) Spain (Indirect) Netherlands (Direct) Ireland (Direct) Total Potential (patients) Potential Market ($ MM) 1,2,3 Total Potential Market #Patients Ocular Melanoma 404 297 295 285 197 79 19 1,576 $ 62 Cutaneous Melanoma 1,625 994 753 801 360 379 73 4,987 $ 206 CRC 9,902 5,300 5,475 7,281 4,016 1,644 335 33,953 $1,339 HCC (Primary) 1,637 720 1,514 2,597 1,087 82 35 7,671 $277 NET 1,783 1,336 1,353 1,299 974 360 98 7,202 $ 281 TOTAL 15,351 8,647 9,389 12,263 6,634 2,545 560 55,389 $ 2,166 Europe Presents Significant Potential Market Opportunity Sources: LEK Consulting, GLOBOCAN, Company estimates. 1) Assumes 2.5 treatments per patient. 2) Assumes ASP of ~$15K USD. 3) Assumes mix of direct sales and distributors. 38 DELCATH SYSTEMS, INC US Market by Disease Device and Drug Combination Liver Metastasis Potential Market # Patients Potential Market # Procedures Potential Market ($MM) 1,2,3 Ocular Melanoma 1,685 4,213 $ 300 Cutaneous Melanoma 7,023 17,557 $ 439 CRC 19,861 49,653 $ 1,241 HCC (Primary) 5,586 13,964 $ 349 NET 8,212 20,530 $ 513 TOTAL 42,367 105,917 $ 2,848 Sources: LEK Consulting, GLOBOCAN, Company estimates. 1) Assume 2.5 treatments per patient. 2) Assume ASP of $75K for Ocular Melanoma.(estimated ultra orphan drug pricing) 3) Assume ASP of $25K in Cutaneous Melanoma, CRC, HCC, NET 39 DELCATH SYSTEMS, INC APAC Market by Disease China (Device) S.

EU o EU early commercial launch underway; reimbursement in key EU markets expected in Q2 o U.S. NDA under review ; ODAC May 2, PDUFA goal date September 13, 2013 Expanding clinical data expected to broaden clinical use and indications Attractive financial model, multiple capital resources available and experienced management team to execute plan 2011 DELCATH SYSTEMS, INC.

EVP, Chief Science Officer, R D Harvard, MIT(HST), Cornell, UMass 33 Bill Appling SVP Medical Device R D AngioDynamics 27 Dan Johnston, Ph.D. VP, Pharmaceutical R D Pfizer, Wyeth 12 26 DELCATH SYSTEMS, INC 2013 Anticipated Milestones First patient enrolled in EAP Q1 2013 Obtained NUB Value 4 interim reimbursement in Germany Q12013 Initiated EU Retrospective Data Collection Q2 2013 ODAC Panel Meeting May 2, 2013 Obtain interim reimbursement in UK Q2 2013 Submission for publications of Phase 3 data and mNET arm of Phase 2 data in Q2 2013 Initiate EU Registry Q3 2013 First commercial sale in APLA Q2 2013 Commence Company s first investigator initiated trial (IIT) Q2 2013 Receive NDA approval for Melblez Kit by PDUFA date of September 13, 2013 First patient enrolled in Company sponsored trial (CST) to expand indications Q4 2013 First patient enrolled in Taiwan HCC pivotal trial Q4 2013 Strategic Partnership for China A Busy Year Focused on US Approval, Clinical Data and EU Commercial Adoption 27 DELCATH SYSTEMS, INC A Compelling Investment Opportunity Concentrating the Power of Chemotherapy Early stage, commercial Company focused on oncology Proprietary CHEMOSAT Hepatic Delivery System allows unique whole organ therapy for the liver CHEMOSAT system has demonstrated extension of progression free survival Addressing large unmet market need for cancer patients who usually die of liver failure Estimated market opportunity of ~$2.5 billion in U.S.

EVP Chief Financial Officer D B, Pagoda Pharma, Schering Plough, Pharmacia, JP Morgan 23 Jennifer Simpson, Ph.D. EVP, Global Head Business Operations Eli Lilly (ImClone), Johnson Johnson (Ortho Biotech) 23 Peter Graham, J.D. EVP, General Counsel, Chief Compliance Officer Global Human Resources Bracco, E Z EM 18 Gloria Lee, M.D., PH.D. EVP, Medical Clinical Affairs Hoffmann La Roche, Syndax Pharmaceuticals, Inc. 21 John Purpura EVP, Regulatory Affairs Quality Assurance E Z EM, Sanofi Aventis 29 Harold Mapes EVP, Global Operations AngioDynamics, Mallinckrodt 27 Krishna Kandarpa, M.D., Ph.D.

Commercialization Strategy Launch in Q1 2014 assuming approval on PDUFA goal date of September 13, 2013 Initial commercial focus on centers that are active in the EAP or participated in the Phase 3 clinical trial Utilize active EAP hospitals as Centers of Excellence for training and support of new centers Intend to seek specific CPT reimbursement code for the Melblez Kit procedure, based upon value proposition relative to other cancer therapies Educate Medical Oncologists via Medical Science Liaison (MSL) Direct strategy to sell to hospital based Interventional Radiologists and Surgeons Participating EAP Centers Provide Immediate Commercial Footprint 23 DELCATH SYSTEMS, INC Barriers to Entry Patent Protection o 6 U.S. patents in force and 6 U.S. patent applications pending o 9 foreign patents in force (with patent validity in 25 countries) and 14 foreign patent applications pending o Primary US device patent set to expire August 2016 o Up to 5 years of patent extension post FDA approval Trade Secret Protection o Developed improved filter media via proprietary manufacturing processes FDA Protection o Orphan Drug Designation granted for melphalan in the treatment of ocular melanoma, cutaneous melanoma and metastatic neuroendocrine tumors, as well as for doxorubicin in the treatment of HCC Provides 7 years of marketing exclusivity post FDA approval o Additional Orphan Drug applications to be filed for other drugs and indications, including melphalan for HCC and CRC Multiple Levels of Protection 24 DELCATH SYSTEMS, INC Financial Summary Cash Cash Equivalents: $42.8 million at March 31, 2013 (unaudited) ATM Program up to $50.0 million available upon registration statement being declared effective by the SEC Committed Equity Financing Facility (CEFF) Up to $23.9 million as of March 31, 2013 Working Capital Line of Credit: $20 million credit facility Debt: None Cash Utilization: Approx. $11.3 million in 1Q 2013 (unaudited) Projected quarterly cash spend: $9 $12 million for first half of 2013 $9 $10 million for second half of 2013 Shares Outstanding: 96.8 million (107.8 million fully diluted 1 ) as of March 31, 2013 1) Fully diluted includes an additional 5.6 million options and 5.4 million warrants 2) Includes 5.6 million shares issued to Terrapin Opportunity L.P. on April 1, 2013 Multiple Capital Resources Available to Execute Plan 25 DELCATH SYSTEMS, INC Management: A Track Record of Success Executive Title Prior Affiliation(s) Years of Experience Eamonn Hobbs President and CEO AngioDynamics, E Z EM 32 Graham Miao, Ph.D.

NDA Under Review Oncology Drug Advisory Committee (ODAC) panel scheduled for May 2, 2013 PDUFA Goal Date: September 13, 2013 Initial indication: unresectable metastatic ocular melanoma in the liver o Provides lowest risk pathway to FDA approval and fastest access NDA filing included: o Comprehensive set of additional data in a new FDA compliant CDISC database o Gen 2 filter as part of the Chemistry, Manufacturing and Control (CMC) module On going discussions with FDA on clinical programs for planned label expansions in HCC,CRC and NET FDA Decision Expected in September 22 DELCATH SYSTEMS, INC U.S.

EU: Initial target countries of Germany, UK, Italy, France, Spain, Netherlands, Ireland. APAC: Initial target countries of China, Japan, S. Korea, Taiwan, Australia. Assumes 2.5 treatments per patient. Assumes EU ASP of $15K; US ASP of $75K (estimated ultra orphan drug pricing); APAC ASP of $5K. 55,389 42,367 189,943 HCC CRC Melanoma NET $2.5B Initial Opportunity * Assumes FDA approval for ocular melanoma metastatic to the liver Long Term Potential Multi Billion Dollar Global Market 8,708 6,563 4,085 8,212 7,202 33,966 19,861 33,953 52,143 5,585 7,671 99,749 0 25,000 50,000 75,000 100,000 125,000 150,000 175,000 200,000 USA EU APAC $300M Initial on label opportunity in Ocular Melanoma in US* $2.2B multi histology opportunity in EU 18 DELCATH SYSTEMS, INC Approved (CE Mark Device) NDA Filing Accepted by the FDA with PDUFA goal date of Sept. 13, 2013 Mutual Recognition of European CE Mark Applications Planned or Submitted Global Commercialization Status Addressing A Multi Billion Dollar Global Market 19 DELCATH SYSTEMS, INC CHEMOSAT: EU Launch Underway Marketing in target EU countries Italy, Germany, France, UK, Ireland, NL, Spain Training completed in key centers o Nine EU Clinical Sites activated as of March, 2013 EU clinicians using CHEMOSAT for a broad range of liver metastases o Use includes: cutaneous melanoma, ocular melanoma, colorectal cancer (CRC), gastric cancer, breast cancer, neuroendocrine tumor (NET), hepatocellular carcinoma (HCC) and Cholangiocarcinoma EU reimbursement in progress o Italy Existing DRG for partial reimbursement identified; supplemental reimbursement applications submitted o Germany Value 4 NUB interim reimbursement granted February 2013 o UK Reimbursement anticipated Q2 2013 Expanding EU Clinical and Commercial Footprint 20 DELCATH SYSTEMS, INC CHEMOSAT: Multiple Tumor Types Treated in Europe Physicians are recognizing the potential of CHEMOSAT in various tumor types CHEMOSAT utilized in Germany, Italy, UK, France, Ireland, and the Netherlands EU Retrospective Data Collection to be initiated in Q2 EU Prospective Registry To Be Initiated Q3 Ocular Melnaoma Cutaneous Melanoma HCC Cholangelcarcinoma mNET Breast Gastric CRC Anal Muc Mel 21 DELCATH SYSTEMS, INC U.S.

Best Alternative Care (BAC) Primary endpoint: Overall Survival Planned phase 2 studies including global Investigator initiated trials (IITs) in multiple indications: HCC, NET, CRC, melanoma Establish PHP/Melphalan as Standard of Care (SOC) for Disease Control in the Liver 17 DELCATH SYSTEMS, INC $2.5 Billion Initial Market Opportunity with Pharmaceutical Like Gross Margins Sources: LEK Consulting, GLOBOCAN, Company estimates.

Ann Oncol. 2008;19:1127 34 2) Alexander, HR, Barlett DL, et al. Ann Surg Oncol, 16:1852 9, 2009 Phase 2 NCI Trial mCRC Cohort Delcath Phase 2 NCI Trial mCRC Cohort 15 DELCATH SYSTEMS, INC Additional Clinical Data Generation Goals: Expand US (PHP: MEL) label indications beyond the initial indication we are seeking Generate robust clinical data to support commercialization FDA has accepted IND Amendment that includes Gen 2 device in Expanded Access Program (EAP), compassionate use (CU), and all future clinical trials Initiated EAP to treat first patient in January, 2013 Activate EU Registry to systematically collect data from commercial experience Establish PHP/Melphalan as Standard of Care (SOC) for Disease Control in the Liver 16 DELCATH SYSTEMS, INC 2013 Clinical Development Plan Planned company sponsored trials, subject to agreement with FDA Hepatocellular carcinoma (HCC) o Global Phase 3 Randomized CHEMOSAT Melphalan vs. best supportive care (BSC) for patients who have failed Sorafenib (or are intolerant) Primary endpoint: Overall Survival Advanced colorectal cancer (CRC) with liver dominant metastasis o Global Phase 3 Randomized CHEMOSAT Melphalan vs. best alternative care (BAC) Primary endpoint: Overall Survival Metastatic Neuroendocrine tumor (NET) with liver dominant disease o Global Phase 3 Randomized CHEMOSAT Melphalan vs.

CHEMOSAT Kit supplied without melphalan 5 DELCATH SYSTEMS, INC The Delcath Hepatic Delivery System Minimally Invasive, Repeatable Procedure That Could Complement Systemic Therapy Improves disease control in the liver Treats macro and micro tumors Controls systemic toxicities Allows for over 100x dose escalation at tumor site 6 DELCATH SYSTEMS, INC Melanoma Liver Metastases A Great Demonstration of CHEMOSAT s Potential A challenging histology Notoriously insensitive to systemic chemotherapy and focal interventions CHEMOSAT has demonstrated ability to extend progression free survival Our Opportunity Ability to achieve ultra high concentrations of chemotherapy provides potential treatment options for a wide variety of cancers in the liver 7 DELCATH SYSTEMS, INC Clinically Differentiated Results Phase 1, 2 and 3 trials with percutaneous hepatic perfusion (PHP) produced positive results in multiple histologies Melanoma Liver Mets o Positive Phase 3 results in hepatic metastatic melanoma o n=93 (90% ocular melanoma, 10% cutaneous melanoma) Neuroendocrine Tumor (NET) Liver Mets o mNET cohort in Phase 2 trial showed encouraging 42% objective response rate (ORR) vs ~10% for approved targeted therapy o median overall survival of ~32 months on ITT basis Hepatocellular Carcinoma (HCC) o Positive signal with high dose melphalan in HCC cohort of Phase 2 trial (5/8 patients) is encouraging when approved systemic therapies have modest efficacy and challenges with tolerability Colorectal Cancer (CRC) Liver Mets o Data from surgical Isolated Hepatic Perfusion (IHP) with melphalan indicates strong potential in well defined patient population with earlier stage CRC yielding ~50 60% median response rate and median OS of 17.4 24.8 mos Safety profiles consistent with pivotal US Phase 3 melanoma trial Encouraging Initial Results on a Broad Range of Histologies 8 DELCATH SYSTEMS, INC Hepatic progression free survival (IRC) Hazard ratio = 0.50 (95% CI 0.31 0.80) P=0.0029 0 5 10 15 20 25 30 Months 7.0 1.7 1.0 0.8 0.6 0.4 0.2 0.0 Proportion of patients surviving 5.3 mo Intent to treat population Best alternative care (BAC) Positive Phase 3 Results Primary Endpoint hPFS PHP Demonstrated 4x or 5.3 months Improvement in Primary Endpoint of hPFS INDEPENDENT REVIEW COMMITTEE (IRC) ASSESSMENT UPDATED ANALYSIS (4 June 2012) Percutaneous Hepatic Perfusion (PHP) Overall progression free survival (investigator) Months 5.4 1.6 1.0 0.8 0.6 0.4 0.2 0.0 Proportion of patients surviving Hazard ratio = 0.42 (95% CI 0.27 0.64) P 0.0001 0 5 10 15 20 25 30 35 40 45 50 55 3.8 mo Intent to treat population Positive Phase 3 Results Overall PFS PHP also Demonstrated a Highly Statistically Significant Improvement in Overall PFS Percutaneous Hepatic Perfusion (PHP) INVESTIGATOR ASSESSMENT UPDATED ANALYSIS (4 June 2012) 9 DELCATH SYSTEMS, INC Best alternative care (BAC) TOTAL PHP vs BAC ONLY Proportion of subjects surviving 0.0 0.1 0.2 0.3 0.4 0.5 0.6 0.7 0.8 0.9 1.0 12 36 0 24 48 60 11.4 Total PHP incl. crossover BAC only Months 4.1 Intent to treat population 7.3 mo Overall Survival Exploratory Subset Analysis Overall Survival Tail For PHP Treated Patients 10 DELCATH SYSTEMS, INC 11 DELCATH SYSTEMS, INC Phase 2 Multi Histology NCI Trial Summary Strong efficacy signals in mNET o 42% objective Response Rate (ORR) vs ~10% for approved targeted therapy o 66% patients had hepatic tumor shrinkage and durable disease stabilization Positive Signal in primary hepatic malignancies (HCC and Cholangiocarcinoma) in 5 of 8 patients Similar safety profiles across tumor types Positive Efficacy Signals In Additional Types of Cancer 12 DELCATH SYSTEMS, INC Phase 2 NCI Trial Metastatic Neuroendocrine Cohort Pre PHP (Baseline) Post PHP #2 (+4 Months) Post PHP #1 (+6 Weeks) Compelling Clinical Data in Attractive mNET Market Phase 2 mNET Tumor Cohort (n=24)* Number (n) Tumor Types Pancreatic NET 13 Carcinoid tumor 3 Other NET 8 Response Partial Response (PR) 10 Stable disease (SD) 6 Progressive disease 3 Not assessed or evaluable 5 Objective Response Rate 42% Median Duration of Hepatic Response Partial Response (n 10) 23.5 months Partial Response/Stable Disease (n=16) 16.8 months Hepatic Progression Free Survival (IIT n=24) Median Hepatic PFS 16.8 Min/Max 2.1, 64.1 Overall Survival After CS Median 31.9 months Min/Max 2.4, 81.1 66% disease control 13 DELCATH SYSTEMS, INC Phase 2 NCI Trial Hepatobiliary Carcinoma Cohort Encouraging Positive Signal for Primary Liver Cancer Source: GLOBOCAN Best hepatic tumor response by modified RECIST assessed by investigators o Stable disease (SD) 4 patients o Partial response (PR) 1 patient o Progressive disease 1 patient o Not assessed or evaluable 2 patients Median duration of response o hPR (N=1) 6.42 months o hPR/SD (N=5) 8.12 months Hepatic progression free survival (ITT N=8) o Median 5.60 months Overall survival (ITT N=8) o Median 9.12 months o Minimum, Maximum 3.4, 20.5 months HCC is the most common primary cancer of the liver, with approximately 750,000 new cases diagnosed worldwide annually Intend to initiate new trials in HCC o Minimum, Maximum 2.7, 12.2 months 14 DELCATH SYSTEMS, INC Substantial clinical evidence of benefit of using ultra high dose melphalan to treat mCRC via isolated hepatic perfusion (IHP) procedure o Over 800 patients treated in 15 studies since 1998 o Patients treated only once o Median response rate of ~50 60% and median OS of 17.4 24.8 mos1,2 o Challenges enrolling at NCI due to competing FOLFOX FOLFIRI trials o 17 patients treated since 2004 o Safety profile expected and consistent with pivotal FDA Phase III melanoma trial Intend to invest in new trials in mCRC Strong Rationale for Using PHP/Melphalan to Treat mCRC 1) van Iersel LB, Gelderblom H, et al.

FDA Proposed indication for the treatment of patients with unresectable ocular melanoma metastatic to the liver Melblez Kit comprised of Melblez TM (melphalan hydrochloride for injection) and the Delcath Hepatic Delivery System Our Product Ex US Markets Marketed under the trade name CHEMOSAT Hepatic Delivery System Regulated as a Class IIb Medical Device Indicated for the intra hepatic of administration of melphalan hydrochloride and subsequent filtration of the venous blood return.

EU o EU early commercial launch underway; reimbursement in key EU markets expected in Q2 o U.S. NDA under review ; ODAC May 2, PDUFA goal date September 13, 2013 Expanding clinical data expected to broaden clinical use and indications Attractive financial model, multiple capital resources available and experienced management team to execute plan 4 DELCATH SYSTEMS, INC US Market Proposed Trade Name Melblez Kit TM (Melblez (melphalan) for Injection for use with the Delcath Hepatic Delivery System) Proprietary Drug/Device Combination Product Regulated as a drug 505(b)(2) NDA by U.S.

These factors, and others, are discussed from time to time in our filings with the Securities and Exchange Commission. You should not place undue reliance on these forward looking statements, which speak only as of the date they are made. We undertake no obligation to publicly update or revise these forward looking statements to reflect events or circumstances after the date they are made. 3 DELCATH SYSTEMS, INC Investment Considerations Concentrating the Power of Chemotherapy Early stage, commercial Company focused on oncology Proprietary CHEMOSAT Hepatic Delivery System allows unique whole organ therapy for the liver CHEMOSAT system has demonstrated extension of progression free survival Addressing large unmet market need for cancer patients who usually die of liver failure Estimated market opportunity of ~$2.5 billion in U.S.

Factors that may cause such differences include, but are not limited to, uncertainties relating to: the outcome of the ODAC meeting, and the impact, if any, of the advisory panel s recommendation on the FDA s decision regarding the Company s new drug application (NDA), timing of completion of the FDA s review of our NDA, the extent to which the FDA may request additional information or data and our ability to provide the same in a timely manner, acceptability of the Phase 1, 2 and 3 clinical trial data by the FDA, FDA approval of the Company's NDA for the treatment of metastatic ocular melanoma to the liver, adoption, use and resulting sales, if any, for the Delcath Hepatic Delivery System in the United States, adoption, use and resulting sales, if any, for the Hepatic CHEMOSAT Delivery System in the EEA, our ability to successfully commercialize the Delivery System in various markets and the potential of the system as a treatment for patients with cancers in the liver, the timing and our ability to successfully enter into strategic partnership and distribution arrangements in foreign markets including Australia and key Asian markets and resulting sales, if any, from the same, patient outcomes using the Generation 2 system, approval of the current or future system for other indications and/or for use with various chemotherapeutic agents, actions by the FDA or other foreign regulatory agencies, our ability to obtain reimbursement for the CHEMOSAT system in various markets, the number of cancer centers in Germany and Italy able to successfully negotiate and receive reimbursement for the CHEMOSAT procedure and the amount of reimbursement to be provided, submission and publication of the Phase II and III clinical trial data, the timing and results of research and development projects, the timing and results of future clinical trials including the initiation of clinical trials in key Asian markets with the CHEMOSAT Hepatic Delivery System device for intra hepatic arterial delivery and extracorporeal filtration of doxorubicin, approval of the CHEMOSAT Hepatic Delivery System to delver and filter doxorubicin in key Asian markets and adoption, sales, if any, and patient outcomes using the same, the timing, price and use, if any, of the committed equity financing facility with Terrapin, the timing and use, if any, of the line of credit from SVB and our ability to access this facility and uncertainties regarding our ability to obtain financial and other resources for any research, development and commercialization activities.

Investor Presentation (NASDAQ: DCTH) April 2013 Exhibit 99.1 2 DELCATH SYSTEMS, INC Forward looking Statements Private Securities Litigation Reform Act of 1995 provides a safe harbor for forward looking statements made by the Company or on its behalf. This presentation contains forward looking statements, which are subject to certain risks and uncertainties that can cause actual results to differ materially from those described.