Full Press Release Details
SOUTH SAN FRANCISCO, Calif., Oct. 31, 2025 (GLOBE NEWSWIRE) -- Cytokinetics, Incorporated (Nasdaq: CYTK) today announced upcoming presentations, including three Late Breaking Science presentations related to MAPLE-HCM (MetoprololvsAficamteninPatients withLVOT Obstruction onExercise Capacity inHCM), at the Hypertrophic Cardiomyopathy Medical Society Scientific Sessions on November 7, 2025, and at the American Heart Association Scientific Sessions 2025 taking place November 7-10, 2025, both in New Orleans, LA.
Hypertrophic Cardiomyopathy Medical Society Scientific Sessions
Late Breaking Science Presentation
Title:Effect ofAficamtenvsMetoprololon Patient-Reported Health Status in Obstructive Hypertrophic CardiomyopathyPresenter:Michael E. Nassif, M.D., University of Missouri Kansas City Healthcare Institute for Innovations in Quality and Saint Luke’s Mid America Heart InstituteDate:November 7, 2025Session Title:Featured Science: Hypertrophic Cardiomyopathy Medical SocietySession Time:6:00 PM – 6:35 PM CTPresentation Time:6:16 PM – 6:22 PM CTLocation:R01
Oral Presentation
Title:Long-term Impact ofAficamtenon Patient-Reported Outcome Measures in Obstructive Hypertrophic Cardiomyopathy: Results From FOREST-HCMPresenter:Shepard D. Weiner, M.D., Columbia University Irving Medical CenterDate:November 7, 2025Session Title:Hypertrophic Cardiomyopathy Medical Society Oral AbstractsSession Time:2:40 PM – 3:30 PM CTPresentation Time:2:50 PM – 2:58 PM CTLocation:R02-R03
Poster Presentation
Title:Outcomes Following Septal Myectomy in Young Patients with Obstructive Hypertrophic CardiomyopathyPresenter:Daniel Kamna, D.O., Oregon Health & Science UniversityDate:November 7, 2025Session Title:Hypertrophic Cardiomyopathy Medical Society PostersSession Time:6:30 PM – 7:30 PM CTLocation:R04-R05 Posters
American Heart Association Scientific Sessions 2025
Late Breaking Science Presentations
Title:Clinical Responses toAficamtenMonotherapy Compared withMetoprololMonotherapy for Obstructive Hypertrophic Cardiomyopathy Outcomes and Disease Burden: MAPLE-HCM Responder AnalysisPresenter:Andrew Wang, M.D., Duke University Medical CenterDate:November 8, 2025Session Title:From Madrid to Mardi Gras: Heart Failure Trials on ParadeSession Time:1:30 PM – 2:45 PM CTPresentation Time:1:59 PM – 2:07 PM CTLocation:211-213
Title:Effect ofAficamtenversusMetoprololMonotherapy on Biomarkers in Obstructive Hypertrophic Cardiomyopathy: The MAPLE-HCM TrialPresenter:Neal K. Lakdawala, M.D., Brigham and Women’s Hospital, Harvard Medical SchoolDate:November 9, 2025Session Title:Biological and Pragmatic Interventions in Heart Failure: From Present to FutureSession Time:8:00 AM – 9:15 AM CTPresentation Time:8:24 AM – 8:32 AM CTLocation:211-213
Moderated Poster Presentations
Title:Improvement in Echocardiographic Measures of Diastolic Function Reflects Improved Exercise Performance in Obstructive Hypertrophic Cardiomyopathy: Insights From the SEQUOIA-HCM TrialPresenter:Henri Lu, M.D., Brigham and Women’s Hospital, Harvard Medical SchoolDate:November 8, 2025Session Title:Beyond the Usual Suspects: Imaging Insights in HCM and Rare CardiomyopathiesSession Time:9:15 AM – 10:30 AM CTPoster Presentation Time:9:43 AM – 9:48 AM CTLocation:Clinical Science Zone 1, Moderated Digital Poster 7
Title:Aficamtenis Safe and Effective in oHCM with Comorbidities Obesity, Hypertension, and Diabetes: a SEQUOIA-HCM Sub-studyPresenter:Matthew M. Y. Lee, Ph.D., MBChB, School of Cardiovascular and Metabolic Health, University of GlasgowDate:November 8, 2025Session Title:Targeting the Thickened Heart: Advances in Hypertrophic Cardiomyopathy TherapySession Time:10:45 AM – 11:55 AM CTPoster Presentation Time:11:13 AM – 11:18 AM CTLocation:Clinical Science Zone 2, Moderated Digital Poster 24
Title:Effect ofAficamtenin Women Compared with Men with Obstructive Hypertrophic CardiomyopathyPresenter:Xiaowen Wang, M.D., MPH, Brigham and Women’s Hospital, Harvard Medical SchoolDate:November 8, 2025Session Title:Heart Failure and Cardiomyopathy: From Bench to BedsideSession Time:3:15 PM – 4:25 PM CTPoster Presentation Time:4:04 PM – 4:09 PM CTLocation:Clinical Science Zone 2, Moderated Digital Poster 22
Title:ChronicAficamtenTreatment Results in Sustained Favorable Cardiac Remodeling in Patients with Symptomatic Obstructive Hypertrophic Cardiomyopathy: Insights From the FOREST-HCM TrialPresenter:Sheila M. Hegde, M.D., MPH, UT Southwestern Medical Center and Brigham and Women’s Hospital, Harvard Medical SchoolDate:November 8, 2025Session Title:Imaging Insights from Multicenter Clinical TrialsSession Time:10:45 AM – 11:55 AM CTPoster Presentation Time:10:45 AM – 10:50 AM CTLocation:Clinical Science Zone 1, Moderated Digital Poster 8
Title:Lactate Dehydrogenase and Clinical Outcomes in Patients with Heart Failure and Reduced Ejection Fraction: Insights From the GALACTIC-HF TrialPresenter:Ryohei Ono, M.D., Ph.D., British Heart Foundation Cardiovascular Research Centre, University of GlasgowDate:November 9, 2025Session Title:Drivers of Heart Failure: Environmental and Behavioral FactorsSession Time:9:15 AM – 10:30 AM CTPoster Presentation Time:10:04 AM – 10:09 AM CTLocation:Clinical Science Zone 2, Moderated Digital Poster 18
Poster Presentations
Title:Semiquantitative Urine Dipstick Protein Assessments Predict Clinical Outcomes in Patients with Heart Failure and Reduced Ejection Fraction: Insights From the GALACTIC-HF TrialPresenter:Ryohei Ono, M.D., Ph.D., British Heart Foundation Cardiovascular Research Centre, University of GlasgowDate:November 8, 2025Session Title:Biomarkers in HF: Past, Present, and FutureSession Time:2:30 PM – 3:30 PM CTLocation:Clinical Science Zone 2
About Cytokinetics
Cytokinetics is a specialty cardiovascular biopharmaceutical company, building on its over 25 years of pioneering scientific innovations in muscle biology, and advancing a pipeline of potential new medicines for patients suffering from diseases of cardiac muscle dysfunction. Cytokinetics is readying for potential regulatory approvals and commercialization ofaficamten,an investigational cardiac myosin inhibitor, following positive results from SEQUOIA-HCM, the pivotal Phase 3 clinical trial in patients with obstructive hypertrophic cardiomyopathy (HCM).Aficamtenis also being evaluated in additional clinical trials enrolling patients with obstructive and non-obstructive HCM. In addition, Cytokinetics is developingomecamtiv mecarbil, a cardiac myosin activator, in patients with heart failure with severely reduced ejection fraction (HFrEF), ulacamten, a cardiac myosin inhibitor with a mechanism of action distinct fromaficamten,for the potential treatment of heart failure with preserved ejection fraction (HFpEF) and CK-089, a fast skeletal muscle troponin activator with potential therapeutic application to a specific type of muscular dystrophy and other conditions of impaired skeletal muscle function.
For additional information about Cytokinetics, visitwww.cytokinetics.comand follow us onX,LinkedIn,FacebookandYouTube.
Forward-Looking Statements
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