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CYRX

You should be aware that these statements are projections or estimates as to future events and are subject to a number of factors that may tend to influence the accuracy of the statements. These forward-looking statement

Key Takeaway: CAUTIONARY NOTE REGARDING FORWARD-LOOKING This Exhibit 99.1 contains forward-looking statements that have been made pursuant to the provisions of the Private Securities Litigation Reform Act of 1995 and concern matters that involve risks and uncertainties that could cause actu

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CAUTIONARY NOTE REGARDING FORWARD-LOOKING
This Exhibit 99.1 contains forward-looking
statements that have been made pursuant to the provisions of the Private Securities Litigation Reform Act of 1995 and concern matters
that involve risks and uncertainties that could cause actual results to differ materially from those projected in the forward-looking
statements. In some cases, you can identify these statements by terminology such as "may," "will," "should,"
"could," "expect," "plan," "anticipate," "believe," "estimate,"
"predict," "potential," "continue" or similar words which are intended to identify forward-looking
statements, although not all forward-looking statements contain these words. Although we believe that our opinions and expectations
reflected in the forward-looking statements are reasonable as of the date hereof, we cannot guarantee future results, levels of
activity, performance or achievements, and our actual results may differ substantially from the views and expectations set forth
in this Exhibit 99.1. You should be aware that these statements are projections or estimates as to future events and are subject
to a number of factors that may tend to influence the accuracy of the statements. These forward-looking statements should not be
regarded as a representation by us or any other person that our events or plans will be achieved. You should not unduly rely on
these forward-looking statements, which speak only as of the date hereof. Except as required by law, we undertake no obligation
to publicly revise any forward-looking statement to reflect circumstances or events after the date hereof or to reflect the occurrence
of unanticipated events. You should, however, review the factors and risks we describe in the reports we file from time to time
with the Securities and Exchange Commission and those reports filed after the date hereof. Actual results may differ materially
from any forward looking statement.
We are redefining the temperature-controlled
supply chain for the life sciences industry by providing a unique and evolving platform of critical products and solutions, including
advanced packaging, informatics, specialty logistics services, biostorage services, and cryogenic life sciences equipment. With
over 600 employees spread across 30 locations worldwide, we are engaged in providing global solutions to the pharma/biopharma,
reproductive medicine, and animal health markets. Our primary focus is on addressing the critical temperature-controlled supply
chain needs within the biopharmaceutical space with an emphasis on serving the rapidly-growing cell and gene therapy, or C&GT,
We are focused on establishing best-in-class,
comprehensive temperature-controlled supply chain solutions that support the expanding global landscape of the life sciences industry.
We believe our growth strategy aligns with the growth of the markets we serve and our customers within them. In particular, we
identified the C&GT market as a high growth market, with unmet supply chain needs that we believe can benefit significantly
from our solutions. The global C&GT market was valued at approximately $4.2 billion in 2019 and is projected to grow to over
$33.1 billion by 2024.
Over the last several years, we have grown
to become a leader in supporting C&GT clinical trials globally. As of the end of the third quarter of 2020, we supported over
500 clinical trials and four commercial therapies, including KYMRIAH by Novartis and YESCARTA by Gilead/Kite. In addition, seven
additional Cryoport supported therapies filed for commercial approval with the U.S. Food and Drug Administration, or FDA, or the
European Medicines Agency, or EMA, as of the end of the third quarter of 2020. Based on publicly disclosed information, industry
data, and internal forecasts, we estimate that up to 23 additional Cryoport supported C&GTs, currently in clinical trials,
may file for regulatory approval during the course of 2021. Commercial approvals of these therapies provide an opportunity to become
significant revenue drivers for us in the future as each of them requires comprehensive temperature-controlled supply chain support
and services at commercial scale, and we expect that many will select us as their critical supply chain solution as a result of
our work in connection with their clinical trials.
We intend to build on our recent history
of developing market-leading, temperature-controlled supply chain solutions and delivering strong growth through the following
We use our competencies and capabilities
to develop comprehensive and reliable, technology-centric solutions that address the specific needs of our customers. Our platform
of temperature-controlled supply chain products and solutions includes cold-chain and cryogenic life sciences equipment, advanced
packaging, informatics, specialty logistics services, biostorage services, kitting, labeling, and fulfillment. These products and
solutions are utilized for temperature-controlled supply chain services in the life sciences industry for personalized medicine,
cell therapies, stem cells, cell lines, vaccines, diagnostic materials, semen, eggs, embryos, cord blood, bio-pharmaceuticals,
infectious substances, and other commodities that require continuous exposure to certain ranges of precision-controlled temperatures
Our Cryoport Express Solutions are comprised
primarily of a sophisticated, cloud-based, logistics management platform, which is branded as the Cryoportal Logistics Management
Platform, or the Cryoportal, Cryoport Express Shippers and the SmartPak Condition Monitoring System, or the SmartPak. The Cryoportal
supports the management of shipments through a single interface, which includes order entry, document preparation, customs documentation,
courier management, near real-time shipment tracking and monitoring, issue resolution, and regulatory compliance requirements.
In addition, it provides unique and incisive information dashboards and validation documentation for every shipment through data
collected by the SmartPak. The Cryoportal can record and retain a fully documented history of all Cryoport Express Shippers, including
chain-of-custody, chain-of-condition, chain-of-identity, and Chain of Compliance information for each shipment, which is
used to ensure that the stability of shipped biologic commodities are maintained throughout the shipping cycle.At the client's
option, recorded information is archived, allowing the client to meet exacting requirements necessary for scientific work and/or
proof of regulatory compliance during the logistics process.
During 2018 we introduced our Chain of Compliance
solution, as a new industry standard within the C&GT market. Our Chain of Compliance goes beyond chain of condition, chain
of custody and chain of identity by providing traceability of the equipment and processes supporting each client or
patient therapy. The Chain of Compliance enables us to recall any single or every transport that an individual Cryoport Express
Shipper has taken, the client(s) it supported, the commodity transported, its performance during transit, and each step that we
perform before the shipper is put back into service. This includes Cryoport Express Shipper performance and requalification history,
commodity history, courier handling and performance history, calibration history, and correlation competencies that can link in
field events to equipment performance. Many of these standards have now been incorporated in the recently released ISO-21973 standard
and we believe they are likely to become regulatory requirements in the near future.
In September of 2019, the Cryoport Express
Advanced Therapy Shippers were launched to address specific needs of biopharma companies developing and commercializing C&GTs.
These Advanced Therapy Shippers provide verification processes to ensure that they have only been used for human-based therapies
and materials and employ advanced validated cleaning methods to minimize the risk of cross-contamination of equipment and materials
during use, delivery, and distribution of biopharmaceutical materials.
We further extended our solutions, capabilities,
and global logistics network through the following recent acquisitions:
In May 2019, we expanded our capabilities
by acquiring Cryogene Partners, a Texas general partnership doing business as Cryogene Labs, or Cryogene. Cryogene operates an
expanding state-of-the-art temperature-controlled biostorage solutions business strategically located in Houston, Texas. Cryogene
is an industry leader in the management of pre-clinical services which include critical biological commodities to support clinical
research, the advancement of C&GTs, GMP biologics, and public health research. It provides customized, end-to-end chain of
custody/chain of condition solutions for its clients.
In October 2020, we further expanded our
capabilities by acquiring CRYOPDP, a leading global provider of innovative temperature-controlled logistics solutions for high
value, time critical and temperature-sensitive pharmaceuticals. CRYOPDP covers a significant portion of the healthcare temperature-controlled
supply chain including packaging, pick-pack kit preparation, premium services and specialty pharma/biopharma courier support. This
acquisition increased our global presence to a network of 27 global supply chain centers in 13 countries. This network gives us
a new advantage when serving global multinational customers and also provides redundancies and backup that reduce supply chain
risk for our customers. CRYOPDP has also developed a cloud-based platform branded as UnITy, which we plan to integrate with our
Cryoportal Logistics Management Platform. UnITy provides functionalities such as Transport Management System, Warehousing Management
System, Quality Management System, a Customer Experience portal, mobile apps for track and trace during transport and storage as
well as integration with transportation agents and business partners.
In October 2020, we made a second acquisition,
acquiring MVE Biological Solutions from Chart Industries, Inc. MVE Biological Solutions provides cryobiological storage and transportation
solutions for the life sciences industry through its advanced line of cryogenic stainless-steel freezers, aluminum dewars and related
ancillary equipment used in the storage and transport of life sciences commodities, which includes the rapidly growing C&GT
business. With three primary facilities, located in Ball Ground, Georgia, New Prague, Minnesota and Cheng-du, China, MVE Biological
Solutions is a leader in serving the life sciences industry throughout the world. The acquisition is a vertical integration that,
in addition to expanding our footprint to handle the growing demand driven by the growth in the C&GT market, helps to secure
our supply of cryogenic shippers and storage equipment. Cryobiological storage and transport clients include medical laboratories,
Last updated: Jan 20, 2021