CureVac to Shift Focus of COVID-19 Vaccine Development to Second-Generation mRNA Technology COVID-19 vaccine efforts to be re-allocated to accelerate the development of second-generation program in collaboration with GSK

to Shift Focus of COVID-19 Vaccine Development to Second-Generation mRNA Technology

Germany/ BOSTON, USA - October 12, 2021 - CureVac N.V. (Nasdaq: CVAC), a global biopharmaceutical company developing

a new class of transformative medicines based on messenger ribonucleic acid ("mRNA"), today announced the strategic decision

to focus its COVID-19 vaccine development towards the development of second-generation mRNA vaccine candidates in collaboration with

GSK and to withdraw its first-generation COVID-19 vaccine candidate, CVnCoV, from the current approval process with the European Medicines

Agency (EMA). In view of a recent EMA communication, CureVac estimates that the earliest potential approval of CVnCoV would come in the

second quarter of 2022. By this time, the companies expect the candidates from the second-generation vaccine program to have progressed

to late-stage clinical development. The decision is also aligned with the evolving dynamics of the pandemic response towards a greater

need for differentiated vaccines to address the developing endemic SARS-CoV2 situation. As a direct consequence, the existing Advanced

Purchase Agreement with the European Commission, which was predicated on employing CVnCoV to address the acute pandemic need, will cease.

CureVac is assessing the possibility of leveraging CVnCoV commitments for the second-generation vaccine candidates. CureVac remains in

contact with the European Commission and is supportive of its public health efforts.

have tightened their collaboration by adding further resources and experts to accelerate development and manufacturing of the broad second-generation

program. The companies anticipate entering clinical development in the next months, aiming to achieve regulatory approval for market

readiness of an improved COVID-19 vaccine in 2022. Published pre-clinical results have shown the strong potential of the initial second-generation

mRNA COVID-19 vaccine candidate, CV2CoV, compared to CureVac's first generation mRNA, CVnCoV. The data demonstrates up to 10x higher

immunogenicity in animal models. In parallel to the work on the second-generation mRNA vaccine technology, GSK and CureVac will accelerate

efforts to progress the development of modified mRNA vaccine constructs.

global fight against COVID-19 continues, and we remain committed to making a difference with a safe and efficacious vaccine. This

goal has not changed, but the requirements to effectively address the virus and emerging variants have changed. In the ongoing

transition from acute pandemic to endemic, our decision to withdraw CVnCoV from the regulatory approval process and focus our

efforts on second-generation mRNA vaccine candidates reflects expected changes in public health needs that our second generation can

potentially address," said Franz-Werner Haas, Chief Executive Officer of CureVac. "We will now take advantage of CVnCoV

learnings and infrastructures to focus our resources on advanced second-generation vaccines in close collaboration with GSK, a

global leader in the vaccine field." Rino Rappuoli, Head of Vaccines R&D, GSK said: "We welcome CureVac's

focus on the promising second-generation mRNA vaccine technology we are developing together as it has shown strong improvement

compared to CureVac's first-generation candidate, CVnCoV, in pre-clinical testing. To complement the development of this

second generation non-modified mRNA technology, we have also initiated the development of modified mRNA technologies as part of our

CureVac-GSK COVID-19 collaboration builds on the existing strategic mRNA technology partnership both companies started in July 2020 for

several selected targets in the field of infectious diseases. The collaboration was recently extended, allocating additional resources

across both companies. The joint development focuses on optimized second-generation mRNA vaccines that offer the potential to target

different COVID-19 variants, the ability to address different diseases in a combination shot and improved vaccine administration formats.

will host a webcast and conference call on Tuesday, October 12, 2021 at 3:00 p.m. CET / 9:00 a.m. EST. The live conference call dial-in

details and webcast link can be accessed via the Investor Relations section of the CureVac homepage at https://www.curevac.com/en/newsroom/events/

Corresponding presentation

slides will be posted shortly before the start of the webcast. A replay will be made available at this website after the event.

CureVac will also host a virtual press

conference in German on Tuesday, October 12, 2021 at 2:00 p.m. CET. The live conference call dial-in details and webcast link can be

accessed via the Investor Relations section of the CureVac website at https://www.curevac.com/en/newsroom/events/ Corresponding

presentation slides will be posted shortly before the start of the webcast.

is a global biopharmaceutical company in the field of messenger RNA (mRNA) technology, with more than 20 years of expertise in developing

and optimizing this versatile biological molecule for medical purposes. The principle of CureVac's proprietary technology is the

use of optimized mRNA as a data carrier to instruct the human body to produce its own proteins capable of fighting a broad range of diseases.

In July 2020, CureVac entered in a collaboration with GSK to jointly develop new products in prophylactic vaccines for infectious diseases

based on CureVac's second-generation mRNA technology. This collaboration was later extended to the development of second-generation

COVID-19 vaccine candidates, and modified mRNA vaccine technologies. Based on its proprietary technology, CureVac has built a deep clinical

pipeline across the areas of prophylactic vaccines, cancer therapies, antibody therapies, and the treatment of rare diseases. CureVac

had its initial public offering on the New York Nasdaq in August 2020. It is headquartered in T bingen, Germany, and employs more

than 700 people at its sites in T bingen, Frankfurt, and Boston, USA. Further information can be found at www.curevac.com.

CureVac Investor Relations Contact

Dr. Sarah Fakih, Vice President Corporate

Communications and Investor Relations

CureVac, T bingen, Germany

T: +49 7071 9883-1298

M: +49 160 90 496949

CureVac Media Contact

Anna Kamilli, Manager Communications

CureVac, T bingen, Germany

T: +49 7071 9883-1684

Bettina J dicke-Braas, Manager

CureVac, T bingen, Germany

T: 49 7071 9883-1087

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CureVac Inc., CureVac Swiss AG and CureVac Corporate Services GmbH (the "company") regarding future events or future

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